OBJECTIVE:To provide suggestions for the setting-up of the current pharmacovigilance(PV)system.METHODS:The characteristics of the setup of the PV system in both US and France were analyzed and the problems encountered in current monitoring system of adverse drug effects were pointed out.RESULTS & CONCLUSION:Both American and French PV systems have their own advantages and we should learn from it and draw useful experiences from them.In constructing PV system,China should make improvement in organization,communication,financial resource and information technology etc.

In order to have a better understanding of the relation between vertical dimension and occlusal force,a meter was made by means of straingauge.Five Japanese men were investi- gated for occlusal force at different vertical dimensions.The measurements showed that the maximal occlusal force of the posterior teeth occured at 8 to 15mm or the vertical dimension, the maximal occlusal forec of the anterior teeth occured at 13 to 18mm.This indicated that the occlusal force was closely related to the state of jaw closing muscle.

Animals ; Blood Glucose ; Cucurbita ; chemistry ; Diabetes Mellitus, Experimental ; drug therapy ; Hypoglycemic Agents ; pharmacology ; Lipids ; blood ; Oxidative Stress ; Polysaccharides ; pharmacology ; Rats

Gastric cancer is a malignant tumor with the second highest incidence and mortality in the world, and China is one of the countries with the highest incidence of gastric cancer in the world. Research on the regulation of cell cycle protein can provide effective evidence for the mechanism of tumor and gene therapy.G1/S phase is the key point for cell cycle regulation,Cyclin D1 and CDK4 gene and P16 play important roles in this phase and have great correlation with gastric cancer,but the exact relationship between these genes and gastric cancer is still unclear. In order to better understand the expression of Cyclin D1 and CDK4 gene and P16 in gastric cancer, the related researches in recent years were summarized in this paper.

Mycoplasma pneumoniae(MP) is the smallest organism that dose not need a host cell for replication.It is one of the most common pathogens of community acquired pneumonia in children.In recent years,the incidence of pneumonia mycoplasma pneumonia increased year by year,and severe pneumonia mycoplasma pneumonia,refractory pneumonia mycoplasma pneumonia cases also increased.MP causes a variety of clinical presentations,in addition to respiratory infections,there are also many extrapulmonary manifestations.Immune response plays a very important part in pathogenesis of MP infection.This article focused on the immune aspects in pathogenesis and extends to some diagnosis and therapeutic implications.

Objective:To investigate the clinical efficacy of long-pulsed 1064nm laser combined with amorolfine hydrochloride in the treatment of patients with onychomycosis. Methods:Totally 106 cases of patients with onychomycosis were randomly divided into the observation group (n=53) and the control group(n=53) according to the random number table. The control group was given 5%amorolfine hydrochloride liniment, while the observation group was treated with long-pulsed 1064nm laser additionally. The course of treatment was 6 months. The clinical efficacy, length of deck in ward areas, length of deck in health zone, clearance of mycology and adverse reactions were compared between the groups. Results:The total effective rate of the observation group(90. 57%) was signifi-cantly higher than that of the control group(75. 47%, P<0. 05). After the treatment, the length of deck in ward areas in both groups were significantly decreased, while the length of deck in health zone were significantly increased (P<0. 05). The length of deck in ward areas in the observation group was significantly lower than that in the control group, while the length of deck in health zone was significantly higher than that in the control group(P<0. 05). The clearance rate of mycology in the observation group (86. 79%) was significantly higher than that in the control group (67. 92%, P<0. 05). There were no serious adverse reactions during the treatment course. Conclusion:Long-pulsed 1064nm laser combined with 5% amorolfine hydrochloride liniment in the treatment of patients with onychomycosis has remarkable, safe and reliable clinical effects, which shows important study value.

Hospital construction is essentially disciplinary construction and personnel development. Improving the quality of department heads in an all round way and bringing into full play their potential and enthusiasm will be of great significance in promoting disciplinary and hospital construction and development. To give play to the role of department heads, it is imperative to enhance their quality, bring into full play their potential and enthusiasm, and appropriately handle relationships with them. Only by doing so can marked achievements be made in hospital construction and development.

By means of chromalum-hematoxylin and thiosulfate aldehydefuchsin stains the magnocellular neurosecretory neuron of the rat hypothalamus was studied. The cell body of neuron containing various amounts of secretory granules was large in size, with a variety of shapes. The axon of neuron showed an beaded appearance; only one in each neuron was very fine in diameter and left hypothalamic nuclei to form the hypothalamo-neurohypophyseal tract. The dendrite, in general, thicker than the axon, did not project outside of the nucleus. Many of the thick short dendrites did not contain secretory granules or only few secretory granules. The thick processes with more secretory granules were considered as dendritic processes. A number of axons and thick processes containing secretory granules also contacted with the endothelium of vessels and the ependyma of the third ventricle. In addition, a group of magnocellular secretory neurons were found in the sub-choroid plexuses of the lateral ventricle.

By means of ABC immunoenzyme technique, the distribution of GnRH neurons and fibers in the brains of rats and mice was observed, The results showed that more than 90% of GnRH neuronal perikarya were concentrated in the diagonal band-medial preoptic area near the organum vasculosum lamina terminalis, extending rostro-dorsally to the medial septic nucleus and caudo-laterally to the supraoptic nucleus region. No GnRH cell body could be found in the mediobasal hypothalamus, GnRH fibers terminated in the median eminence via the periventricular and lateral tracts. In the rostral median eminence, fibers were present in its entire layers and width, and caudally separated into two laterally-located bundles. The difference of GnRH system between rodents and primates, as well as its significance in reproduction are discussed.