Postprandial hyperglycemia is one of the characteristics of glucose profiles in Chinese T2DM patients. High-ratio premix insulin analogues with advantages of excellent pharmacokinetic characteristics and flexible and convenient administration provide a comprehensive solution for Chinese T2DM patients to effectively control postprandial glucose and reduce blood glucose fluctuation. This paper is a literature review on its clinical evidence and experience.

Chinese genuine regional herbs are a combination of nature resource and traditional knowledge. Although we can make it to be an intellectual property product through applying geographical indication or certification mark, the value realization of Chinese genuine regional herbs should be supported by the merchant capital. Meanwhile, the merchant capital also disturbs the reasonable market price of Chinese genuine regional herbs. We should combine the merchant capital with Chinese genuine regional herbs, apply permission for sale and set up a new professional cooperation mode to maintain the market credibility and reasonable price of Chinese genuine regional herbs.

Atopic dermatitis is a common chronic recurrent atopic constitution-associated inflammatory skin disease mainly characterized by eczematous lesions and itching. Its etiology and pathogenesis are still not very clear, and there are many controversies about its origin, definition, clinical phenotypes and diagnostic criteria. This review analyzes and discusses these controversies in order to provide a meaningful reference for the diagnosis and treatment of atopic dermatitis.

No abstract available.
Animals ; Embryo Implantation* ; Embryonic Structures* ; Female ; Mice* ; Pregnancy

No absteact available.
Resuscitation*

No abstract available.
Agglutination* ; Alisma* ; Animals ; Erythrocytes* ; Mice* ; Plantago*

Objective To study the relation of disease classification and osteoporosis in patients with chronic obstructive pulmonary disease,and to provide a theoretical basis for secondary osteoporosis.Methods A retrospective analysis of clinical data of 126 patients with COPD from January 2012 to December 2014 was made.50 non-COPD patients were included as control group,the pulmonary function and BMD of the femoral neck,trochanter,Ward Dis-trict were detected.And according to FEV1 , all patients were divided into mild pulmonary dysfunction group ( n=31),moderate pulmonary dysfunction group (n=54) and severe pulmonary dysfunction group (n=41);the rate of osteoporosis were measured in COPD group and non-COPD group,the difference of BMD were compared in patients with different pulmonary injury.Results ( 1 ) There were 45 cases of osteoporosis in 126 patients with COPD, accounting for 35.7%, 22 cases of osteopenia, accounting for 17.5%.There were 9 cases of osteoporosis in 50 patients with non-COPD,accounting for 18%,the incidence of osteoporosis were statistically different in COPD group and non-COPD group,χ2 =5.281,P<0.05.(2)The BMD of the femoral neck in mild COPD group,moderate COPD group,severe COPD group and non-COPD group were (0.74 ±0.11) g/cm,(0.66 ±0.08) g/cm,(0.56 ± 0.05)g/cm and (0.94 ±0.10) g/cm,the BMD of trochanter were respectively (0.71 ±0.12) g/cm,(0.63 ± 0.07)g/cm,(0.56 ±0.05)g/cm and (0.95 ±0.08)g/cm,the BMD of Ward District were (0.88 ±0.14)g/cm, (0.72 ±0.10)g/cm,(0.61 ±0.07)g/cm and (0.96 ±0.09)g/cm respectively,which were statistically significant (F=7.557,6.852,7.432,all P<0.01).The BMD of the femoral neck,trochanter,Ward District in COPD group were significantly less than non-COPD,and the more severe of pulmonary dysfunction,the more decreases of bone density.(3) The FEV1% in osteoporosis group,osteopenia group,normal BMD group were respectively (59.0 ±8.7)%,(77.7 ±7.6)% and (49.4 ±15.8)%;the FVC% were (77.8 ±28.8)%,(88.9 ±38.4)%,(73.8 ± 21.1)%;the FEV1/FVC were (66.5 ±20.6)%,(59.8 ±24.2)%,(34.1 ±3.6)%(F=9.554,5.556,7.487,all P<0.01),Conclusion There were a certain correlation between BMD and lung function.Osteoporosis is one of the extrapulmonary effects in elder COPD patients.So BMD should be regularly monitored for helping for early prevention and treatment of osteoporosis and development in osteoporosis,and improving lung function and clinical efficacy.

Objective To explore the clinical characteristics and rehabilitation training of abnormal lateral consonant, namely/l/, of pa-tients with functional articulation disorders (FAD). Methods 107 patients with FAD were observed of the clinical characteristics of/l/. 30 pa-tients with/l/articulation disorder accepted speech training. The correlation and simple linear regression analysis were carried out on/l/ar-ticulation disorders and age. Results The articulation disorder of/l/ mainly showed replacement for/n/,/y/,/r/,/d/ or omission. When/l/combined with vowels contained/i/and/ü/, the main error was omission. When/l/combined with vowels contained/a/,/o/,/e/or/u/, the er-rors trended to be replacement rather than omission. After speech training, the patients made less mistakes about/l/(P<0.001). The frequen-cy of/l/articulation disorders was negatively correlated with age (r=-0.840). The result of simple linear regression analysis showed that the determination coefficient was 0.422. Conclusion The/l/articulation disorder mainly shows replacement or omission, varied with the vow-els. The targeted rehabilitation training may be helpful. Age plays an important role in the outcome of/l/articulation disorder.

Objective To investigate the protection of Rhodioloside on brain tissue in diabetic rats. Methods The rats were randomly divided into six groups: a normal control group, a model control group, a Rhodioloside high, medium and low dose group, and a positive control group(n=16). Except normal control group, the diabetic models were set up by intraperitoneal injecting STZ(60 mg/kg). And then, the Rhodioloside high, medium, low dose group were respectively given Rhodioloside solution(100、50、25 mg/kg) by intragastrical administration(ig), the positive control group was given metformin hydrochloride(25 mg/kg) by ig, the normal control group and positive control group were given normal saline(NS). Before the drug was given and 4, 8, 12 weeks after, the level of blood sugar was determined. And 12 weeks later, the body weight was detected; the activity of CPK, LDH and the level of T-AOC in serum were determined; the activity of SOD, GSH-Px, CAT and the content of MDA in brain tissue were determined; and the histopathological changes of the brain tissue was observed by HE staining.Results Compared with the model control group, the level of blood sugar (16.0 ± 0.9 mmol/Lvs. 18.0 ± 1.2 mmol/L) in Rhodioloside high dose group was significantly decreased (P<0.01), the activity of CPK(240.7 ± 62.3 U/Lvs. 312.5 ± 78.2 U/L) and LDH (265.4 ± 54.6 U/Lvs. 346.3 ± 73.8 U/L) in serum were significantly decreased (P<0.01), the level of T-AOC (10.8 ± 2.8 U/Lvs. 8.7 ± 2.4U/L) was significantly increased (P<0.01); the activity of SOD(11.5 ± 3.2 U/mgvs. 8.1 ± 2.9 U/mg), GSH-Px(13.1 ± 2.8 U/mgvs. 11.4 ± 2.5 U/mg), CAT(3.8 ± 1.1 U/mgvs. 2.6 ± 0.8 U/mg) in brain tissue were significantly increased (P<0.05,P<0.01), and the content of MDA (5.3 ± 1.4 U/mgvs. 6.3 ± 1.8 U/mg) in brain tissue were significantly decreased (P<0.01), which were better than Rhodioloside low dose group; but compared with positive control group, the difference was not significant (P>0.05). The brain histopathological changes of Sal treated groups were significantly improved, while the treatment effect of Rhodioloside high dose group was the most significant.Conclusions Rhodioloside had dose-dependent protective effect on the brain tissue in diabetic rats, whose mechanism perhaps related to its effects on enhancing the activity of antioxidant enzymes, and reducing the damage of oxidative stress.

To explore the significance of hypothyroidism and subclinical hypothyroidism screening in pregnancy.A total of 278 pregnant women were divided into three groups of clinical hypothyroidism (n =36),subclinical hypothyroidism (n =103) and normal control (n =139).Their clinical profiles,pregnancy outcomes and fetal status were analyzed.The incidences of abortion (11.1％),premature delivery (8.3％),preeclampsia (11.1％),gestational diabetes mellitus (GDM,13.9％),anemia (16.7％),fetal distress (8.3％) and fetal growth retardation (FGR,5.6％) in clinical hypothyroidism group were higher than those in normal control group (2.9％,1.4％,1.4％,2.2％,4.3％,0.0％ and 3.6％).And the differences were statistically significant (P ＜ 0.05).The incidence of adverse pregnancy had a significant correlation with hypothyroidism in pregnant women.Therefore screening of thyroid functions is essential for improving pregnancy outcomes of pregnant women with hypothyroidism.