Visual function in early age-related macular degeneration (AMD) were observed by contrast sensi-tivity(cs), macular threshold, FM 100-Hue test, dark adaptation, and the Amsler grid. All patients with early AMD achieved corrected visual acuity of 1.0 or better. The results revealed that early AMD showed one or more of following: abnormal macular light sensitivity (MLS), hue discripmination, CS, threshold of dark adaptation, and Amsler grid, comparing with those of the normal controls. These tests proved useful for the early diagnosis of AMD, and their sensitivity was found to be in the following descending order: MLS, FM100-hue, CS, and Amsler grid.

Objective:To study the effects of curcumin on the activity of ATPase and the mechanism of apoptosis in U-251 cell.Methods:U-251 cells were treated with 20,40,80,100?mol/L curcumin for 24 h and the growth inhibition rates of U-251 cells were measured with MTT method.Cell apoptosis was inspected with flow cytometry(FCM).The activities of ATPase were determined by colorimetry method.Results:Curcumin inhibited the proliferation of U-251 cells and induced apoptosis of U-251 cells.level of ATPase in U-251 plasma Membrane was low remarkably.Conclusion:Curcumin induced apoptosis and inhibited proliferation of U-251 cell via inhibition of activation of plasma Membrane ATPase.

Five male and one female patients with IPVS caused by infarction of occipital cortex and optic radiations of brain were reported. The ages were in the range from 21 to 69 years. The evidence of diagnosis included sudden loss of visual acuity in both eyes, normal fundus, homonymous defect of visual field, infarction of brain in CT scan, without other positive signs of central nervous system or headache or eye pain before or at the time of attack. All the patients were treated by injection of Co- Anisodine Ⅰ and Ⅱ at acupuncture points with satisfactory effects. The therapy is safe, effective, and reliable. The clinical features and the treatment mechanism were disscused.

Thirty-six patients with normal vision in one eye coupled with advanced age-related macular degeneration(AMD)in the fellow eye,and 36 eyes with drusen in one eye coupled with macular drusen in the fellow eye,and 36 normal subjects(36 eyes) were measured by FM100-Hue test.All the tesed eyes had corrected vision of 1.0 or better and had drusen in the fundus.The results showed that the total errors score of FM100-Hue test of patients whose fellow eye suffered from advanced AMD compared with that of the patients whose fellow eye did not suffer from advanced AMD,difference between the two groups in the red and panchromatic regions was statistically significant(P

Animals ; Biopsy, Needle ; Humans ; Kidney ; ultrastructure ; Mice ; Mice, Inbred BALB C ; Microscopy, Electron, Transmission ; methods ; Specimen Handling

Thrombolysis is still an important treatment modality in patients with ST-segment elevation myocardial infarction (STEMI) in a hospital without percutaneous coronary intervention (PCI) facility. However, the optimal treatment after thrombolysis is still unclear. Conservative treatment after thrombolysis was recommended in the past. "Guidelines for percutaneous coronary intervention (2009)" also suggested that the condition of STEMI patients should be evaluated to determine whether the patient should be transferred to a hospital with PCI facility. But this suggestion lacksed evidence-based support. In recent years, several clinical trials suggested that immediate transfer to the nearest interventional centre for PCI was plausible regardless of success or failure in thrombolysis in local hospital, and this might reduce the incidence of cardiovascular events in patients with STEMI.

Background Many surgical techniques are used to improve the postoperative visual acuity for rhegmatogenous retinal detachment(RRD)during recent decade,and scleral buckling surgery is one of these operations.Whether the visual function after operation can be rescued is an important issue. Objective The aim of this study was to analyze the risk factors of influencing the postoperative vision following scleral buckling surgery for primary macula-off RRD. Methods The clinical and follow-up data from consecutive series of 116 eyes of 116 patients received scleral buckling surgery for primary maeula-off RRD were retrospectively reviewed.The relationship of multiple factors,including age,preoperative best corrected visual acuity(BCVA),duration of disease,refractive error,location of retinal hole,number of retinal hole,area and height of retina detachment,management of subretinal fluid and intravitreal gas injection,with visual acuity were analyzed respectively by χ2 test.The correlations among statistically significant factors with postoperative vision were analyzed by multivariate Logistic regression analysis.Written informed consent was obtained from any patient before surgery. Results The postoperative vision outcome was found with significantly difference among different preoperative vision groups(P=0.002)and different course (P=0.009).There were significant differences between the groups with different preoperative BCVA(P=0.002)and duration of disease(P=0.009).Multivariate Logistic regression analysis showed that the preoperative BCVA was the only variable affecting postoperative visual result(r=0.400,P=0.009).Considerable linear correlation wag seen between preoperative vision and postoperative vision(r= 0.400,P=0.000).The probability with postoperative vision of t>0.4 in the eyes with preoperative≥0.05 was 3 folds more than that of preoperative<0.05(OR=2.992).The better visual outcome after scleral buckling surgery was seen in the eyes with the course≤7 days. Conclusion Preoperative BCVA and duration of disease are the key factors associated with the postoperative BCVA.Scleral buckling surgery should be performed within the first week for primary macula-off RRD.

Sancai and Zhonghe are important parts of Chinese traditional culture. Their enriched connotation continues to influence Chinese ancient science and the development of TCM. Sancai-Zhonghe-TCM is a complex relationship, and this article focused on the relationship among the three. This article pointed out that the Zhongheand Sky and Earth form Sancai; Zhonghe and human corresponding reflects the overall concept of TCM, and is further enrichment of the unique theoretical system of TCM between man and universe correspondence. Zhonghe and qi corresponding has an important influence on the TCM essence, qi and spirit theory, supplemented by charts to describe.

Objective To investigate the clinical effect of minimally invasive surgery via basisylvian fissure approach in the treatment of severe hypertensive cerebral hemorrhage in basal ganglia. Methods The Study Group included 28 patients who received a minimally invasive surgery via basisylvian fissure approach, while the Control Group had 26 patients who underwent a traditional hematoma removal. Comparisons were made between the two groups on short-term (1 month) and long-term (6 months) effects. Results The rates of excellent or good short-term outcomes and mortalities were 53.6% (15/28) and 17.9% (5/28) in the Study Group, and 46.2% (12/26) and 15.4% (4/26) in the Control Group, respectively, without significant differences between the two groups (?2=0.297, P=0.586; ?2=0.000, P=1.000). However, the activity of daily life (ADL) grade I~Ⅲ accounted for 63.2% (12/19) of long-term survivors in the Study Group, which was superior to the Control Group (23.6%, 4/17) (z=-2.189, P=0.029). Conclusions Minimally invasive surgery for severe hypertensive cerebral hemorrhage in basal ganglia provides better life quality of survivors after operation than traditional hematoma removal.

Histamine H 1R antagonists are mainly administered to treat the diseases of hypersensitivity reaction. And histamine H 2R antagonists are mainly administered to treat gastroenteric diseases. But in recent years administered simultaneously H 1R and H 2R antagonists can enhance their effects. Combination of H 1R and H 2R antagonists has good therapeutic effect on hypersensitivity reaction, cancers, asthma, etc, and can eliminate side effects.