For more than past hundred years, Engels F. thought that the nature of life was protein. The human was decided by 2 factors, including genome and various influences of environment. The establishment of science of protein system (proteomics) is a break through of biology in 21st century.
Genomics ; Proteomics

Proteomics opened a complete new way in the medical and pharmaceutical sector. It helped detecting causes of unknown diseases, early diagnosing, contributing to optimal treatment of many diseases, and manufacturing new drugs as molecular mechanism. It is hoped that proteomics will be used to understand and treat cancer
Genomics ; Proteomics

In the 21st century, proteomics, a new science, appears in the biology. Proteomics studies the human protein, opens a new era of molecular pathology. The scientists suggest that the human being is determined by 2 factors: the genetic system or human genome and various influences of surrounding environment. From which, proteomics have been become the turning point of the biology at the beginning of 21st century.
Proteomics ; Biology

In Trang An polyclinics in Ha Noi, with ELISA technique, 35 healthy people (27 female aged 20-38, 8 male aged 25-37) undergone an examination of serum CA153-3 and 31 other healthy people (17 female aged 21-38, 14 male aged 22-41) an examination of resum CA125. The technique is complicated needing precaution and accuracy; for each examination, it is recommended a standard graphic with a standard sample determined antigen concentration. CA15-3 normal concentration is 2.37-18.17 U/ml, and CA125 is 7.17-38.37 U/ml
Enzyme-Linked Immunosorbent Assay ; methods ; serum

The tumor marker CA 72-4 has been determined sera of gastric cancer patients to evaluate its role in the diagnosis and the monitoring of treatment. Adenocarcinoma of the stomach: 68 (38 men, 30 women; age 17-70) Gastric ulcer and gastritis: 10 (male: 8, female: 2; age 30-72). Criteria of diagnosis: cytologic examination. 40 patients have been monitored CA 72-4 during one month after operation. There were high statistical difference of CA 71-4 concentrations between cancer and healthy groups (p< 0.001); but no difference between ulcer and healthy people (p<0.005) has been found. The specificity of CA 72-4 for gastric cancer was 100%; sensitivity: 73.53%; Positive predictive value: 100%; Negative predictive value: 35.7%. 77.5% of cases had decreased levels of CA 72-4 after surgery. But in 4 cases, the increased concentrations of this marker correlated with residual tumor. The results showed that CA 72-4 proved to be specific and sensitive in the diagnosis and prognosis and monitoring of surgical treatment of gastric cancer.
Diagnosis ; Stomach Neoplasms ; neoplasms

This paper introduces the troponin, a new gold standard for diagnosis of myocardial infarction and role of troponin in other diseases. The authors introduced also some new standards for diagnosis of the myocardial infarction such as cut-off value, isoenzyme CK-MB, GOT, myoglobin and LDH
Troponin ; Cardiomyopathies ; Infarction ; diagnosis ; Myocardial Infarction

We have a step backwards in comparing with the previous 40 years in the education and the organization of medical laboratory examination. While our equipment and techniques have got new great success and the needs have increased. Typically, in clinical briefing, laboratory doctors and technicians have been always absent, it seems that it is due to the leak of a deep knowledge and a large skill of laboratory. Therefore their roles were reduced. An improvement in the programm of formation of laboratory doctors and experts with various branches: biochemia, hematology, blood perfusion was recommend
Outpatient Clinics, Hospital ; Technology, Medical ; Laboratories ; diagnosis ;

Disease produce cancer is quite complicated. Cancer arise and develope by the disorder of growth control function and disorder of sucidal cells process, the forming artery, metastasis and a sudden mutation of gene. Mainly factors that produce cancer are caused by genetic factor, life style and enviromental factors. These ones influence mutually. Currently, diagnosis of cancer are often late. Some tumor markers are used for prediction of cancer. Some evidences on early detective value of metastasis cancer in some cancer gene tests in tissue and blood by using RT-PCR
Molecular Biology ; Neoplasms ; Tumor Markers, Biological

The great progresses of molecular biology also contribute to find out basic multisided of disease formed cancer. The main marks of molecular tumor are: pregene tumor, gene tumor, gene-inhibition tumor, telemerase, and survivin, acid nucleic. Molecular tumor are based for some new therapy methods to cure cancer: gene therapy, immune therapy, prevent of tumor growing up and penetrate tumor cells
Molecular Biology ; Neoplasms ; Neoplasms, Germ Cell and Embryonal

The development of molecular biology help to clearly understand about pathophysiological mechanisms of diabetes mellitus are due to genetic factors and life environment. The diabetes divided up: type 1 diabetes, type 2 diabetes, and other types. In 1999, American Diabetes Association and WHO advanced a new classification, following: type A (type 1 diabetes), type B (type 2 diabetes), type C (MODY - onset in young adult), type D (diabetes at pregnancy and tolerated glucose disorders in pregnancy)
Diabetes Mellitus ; Diabetes Complications ; Molecular Biology ; Knowledge