BACKGROUND: Endemic areas of Clonorchis sinensis are in Asia including Korea, China, Taiwan and Vietnam. Its metacercariae consumed in uncooked, or undercooked, unfrozen fish can present human a hazard. Purposes of this study are 1) to observe the effect of each food-processing method and each storage method on C. sinensis metacercariae and 2) to suggest basis to be referred as an indicator in prevention. METHODS: Live metacercariae of C. sinensis in fish collected from Nakdong River in Korea were isolated by pepsin digestion, then were injected into the center of regular-sized muscle protein (1 cm3) of flesh water fish. The sample proteins containing metacercaria were processed according to each food-processing method (heating, frying, boiling) and each storage method (chilling, freezing, pickling with vinegar, salt and soybean sauce). After these procedures, the number of dead metacercariae were counted. RESULTS: It took 10 seconds to kill all the metacercariae in muscle protein in deep frying (180 degrees C), 30 seconds in boiling (100 degrees C) and 60 seconds in dry heating. Metacercariae did not lose all the viability in 4-6 degrees C after 40 days, but lost in -10degrees C and pickling after 5 days, and in salting (salt and soybean sauce) after 3 days. CONCLUSION: These results indicated that the storing in low temperature and in such as vinegar, salt, and soybean sauce was not effective to lose the viability unless if it was kept for a long period of time. Among the food-processing methods, frying in soybean oil was the most effective method to lose the viability of metacercariae.
Acetic Acid ; Asia ; China ; Clonorchis sinensis* ; Digestion ; Freezing ; Heating ; Hot Temperature ; Humans ; Korea ; Metacercariae ; Muscle Proteins ; Pepsin A ; Rivers ; Soybean Oil ; Soybeans ; Taiwan ; Vietnam

Non-Hodgkin's lymphoma presented as a malignancy of the uterine cervix is exceedingly rare disease and accounts for approximately only 0.12-0.6% of extranodal lymphomas. There is no consensus on the management and prognosis of the disease because of its extreme rarity. Previously, treatment of this disease has been radiation therapy, surgery or chemotherapy either alone or in combination. We present the case of a 45-year-old woman diagnosed with diffuse, large B-cell non-Hodgkin's lymphoma of the uterine cervix. We administered neoadjuvant chemotherapy according to CHOP protocol (cyclophosphamide, adriamycin, vincristine, and prednisone) followed by hysterectomy and bilateral salpingo-oophorectomy. The patient is alive 20 months after the initial diagnosis. We report the case with a brief review of literature.
B-Lymphocytes ; Cervix Uteri* ; Consensus ; Diagnosis ; Doxorubicin ; Drug Therapy* ; Female ; Humans ; Hysterectomy ; Lymphoma* ; Lymphoma, Non-Hodgkin ; Middle Aged ; Prognosis ; Rare Diseases ; Vincristine

Endodermal sinus tumor (EST) is a rare malignant germ cell tumor arising usually in the gonads such as the testis or ovary. However, 10-15% of EST cases may arise in the extragonadal sites, such as sacrocoxygeal area, mediastinum, vagina, brain and retroperitoneum in a frequent occurring order. To our knowledge there are only 2 case reports of extragonadal EST, one originating from the omentum in 1998, and another which was localized in the pelvis in 2003. We report one case of extragonadal sinus tumor which arose in appendix and mesentery in the 19-year-old female with a review of the literature.
Appendix* ; Brain ; Endoderm* ; Endodermal Sinus Tumor* ; Female ; Gonads ; Humans ; Mediastinum ; Mesentery* ; Neoplasms, Germ Cell and Embryonal ; Omentum ; Ovary ; Pelvis ; Testis ; Vagina ; Young Adult

Meckel Gruber syndrome consisting of an occipital encephalocele, polycystic kidney disease and polydactyly is a rare autosomal recessive disorder with a recurrence risk of 25%. Targeted ultrasonography in late embryonic or early fetal stages of pregnancy has great importance in diagnosis and management of affected pregnancy in high risk groups due to incomplete genetic mapping of meckel syndrome gene (MKS). We present a case of prenatal diagnosis at 14 weeks' gestational age of Meckel Gruber syndrome in a woman, who experienced same disorder in her previous pregnancy.
Diagnosis ; Encephalocele ; Female ; Gestational Age ; Humans ; Polycystic Kidney Diseases ; Polydactyly ; Pregnancy ; Prenatal Diagnosis ; Recurrence ; Ultrasonography

PURPOSE: The purpose of this study was to assess the frequency of acute rheumatic fever(ARF) among children in Korea and to describe trends in its clinical characteristics compared to data from a previous study(1978-1987). METHODS: A mailed questionnaire survey sent to the pediatric departments of 13 general hospitals in Korea requested the total number of patients with ARF and its clinical manifestations from Jan. 1988 to Dec. 1997. These data were compared with the data from a previous study (1978-1987) to evaluate the clinical trends in occurrence and clinical manifestations of ARF during the last 20 years in Korea. RESULTS: The average number of patients with ARF for the 10-year period(1988-1997) was 0.74 per 1,000 annual pediatric inward patients. There was a significant decrease in incidence during the study period. There were 115 male and 85 female patients with ARF, and 97.5% of total patients were 6 to 15 years old. 126 out of 200 patients(63.0%) had a history of preceding upper respiratory infection(URI). The percentage of major manifestations were as follows; carditis(66.5%),polyarthritis(54.0%), erythema marginatum(12.0%), chorea(7.5%) and subcutaneous nodule (6.0%). Clinical findings of carditiswere cardiac murmur(91.0%), cardiomegaly in chest PA(34.6%), congestive heart failure(15.8%). The electrocardiographic findings were PR interval prolongation (37.6%), right ventricular hypertrophy (RVH) and left ventricular hypertrophy(LVH)(15.8%), QT interval prolongation(13.5%). Doppler echocardiographic valvular lesions were mitral insufficiency(96.2 %), aortic insufficiency(39.8%). Minor and other clinical manifestations were fever(69.0%), arthralgia (56.5%), sore throat(28.5%). CONCLUSION: There was a steady decrease in the number of patients with ARF during the study period from 1988 to 1997. A sudden decrease in number of patients with ARF between the two study periods is likely due to patients with valvular heart disease, possibility of double registration, and wide spread use of echocardiography for accurate diagnosis.
Adolescent ; Arthralgia ; Cardiomegaly ; Child* ; Diagnosis ; Echocardiography ; Electrocardiography ; Erythema ; Estrogens, Conjugated (USP) ; Female ; Heart ; Heart Valve Diseases ; Hospitals, General ; Humans ; Hypertrophy, Right Ventricular ; Incidence ; Korea ; Male ; Postal Service* ; Surveys and Questionnaires* ; Rheumatic Fever* ; Thorax