1.Cost-benefit issues about human papillomavirus (HPV) testing.
Korean Journal of Gynecologic Oncology 2006;17(3):183-187
Recently, a number of evidences that human papillomavirus (HPV) testing was efficient in cervical cancer screening were introduced. Moreover, successful trial outcome of preventive cancer vaccine opened new era of cervical cancer prevention. However, undoubtedly, applying new cancer screening and prevention strategy would bring on economical concern about increased medical expense. Therefore, appropriate cost-benefit analysis is very important before establishing new strategy as standard policy. In this article, we presented a few recent results about cost-benefit effectiveness by other group. And we also suggested what would be needed to perform successful.
Cost-Benefit Analysis
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Early Detection of Cancer
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Humans*
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Mass Screening
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Uterine Cervical Neoplasms
2.Cervical adenocarcinoma in situ with negative conization margin: negligible or not?.
Journal of Gynecologic Oncology 2011;22(1):1-2
No abstract available.
Adenocarcinoma
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Conization
3.The role of neoadjuvant chemotherapy in ovarian cancer patients with extensive tumor burden.
Journal of Gynecologic Oncology 2011;22(4):299-300
No abstract available.
Humans
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Ovarian Neoplasms
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Tumor Burden
4.Coexisting carcinoma in endometrial hyperplasia: does more risk factor mean better discrimination?.
Journal of Gynecologic Oncology 2013;24(1):1-2
No abstract available.
Risk Factors
6.Do we need a better marker for successful ovarian cancer surgery?.
Journal of Gynecologic Oncology 2017;28(1):e21-
No abstract available.
Ovarian Neoplasms*
7.Feasibility and Safety of Extensive Upper Abdominal Surgery in Elderly Patients with Advanced Epithelial Ovarian Cancer.
Myong Cheol LIM ; Sokbom KANG ; Yong Jung SONG ; Sae Hyun PARK ; Sang Yoon PARK
Journal of Korean Medical Science 2010;25(7):1034-1040
We performed a retrospective study to evaluate the feasibility and safety of extensive upper abdominal surgery (EUAS) in elderly (> or =65 yr) patients with advanced ovarian cancer. Records of patients with advanced epithelial ovarian cancer who received surgery at our institution between January 2001 and June 2005 were reviewed. A total of 137 patients including 32 (20.9%) elderly patients were identified. Co-morbidities were present in 37.5% of the elderly patients. Optimal cytoreduction was feasible in 87.5% of the elderly while 95.2% of young patients were optimally debulked (P=0.237). Among 77 patients who received one or more EUAS procedures, 16 (20.8%) were elderly. Within the cohort, the complication profile was not significantly different between the young and the elderly, except for pleural effusion and pneumothorax (P=0.028). Elderly patients who received 2 or more EUAS procedures, when compared to those 1 or less EUAS procedure, had significantly longer operation times (P=0.009), greater blood loss (P=0.002) and more intraoperative transfusions (P=0.030). EUAS procedures are feasible in elderly patients with good general condition. However, cautious peri-operative care should be given to this group because of their vulnerability to pulmonary complications and multiple EUAS procedures.
Abdomen/*surgery
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Adult
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Age Factors
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Aged
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Disease-Free Survival
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Female
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*Gynecologic Surgical Procedures/adverse effects
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Humans
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Kaplan-Meiers Estimate
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Middle Aged
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Ovarian Neoplasms/mortality/*pathology/*surgery
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Retrospective Studies
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Treatment Outcome
8.Epstein-Barr virus-transformation of B-cell lines in ovarian cancer patients: feasibility of genomic storage for unlimited use.
Journal of Gynecologic Oncology 2009;20(4):243-245
OBJECTIVE: The aim of the current study is to test whether immortalized B-lymphocyte cell line via Ebstein-Barr virus (EBV) transformation is feasible and can be an unlimited source of genome wide study. METHODS: We obtained peripheral whole blood from 5 ovarian cancer patients and immortalized the B-cell lines using EBV transformation. The success rate was analyzed and the bio-identity of the genome was performed using human leukocyte antigen (HLA) identity test. RESULTS: EBV transformation was successful in all 5 cases (95% confidence interval, 46.3% to 100%). After cryopreservation of EBV-transformed B-cell lines and subsequent thawing, we observed that all cell lines were viable and proliferative. To check bio-identity, HLA-A, B, and DR were tested between the genome of the original samples and the transformed samples. The HLA typing revealed that all observed HLA-A, B, and DR type was identical in 5 cases before and after EBV-transformation. CONCLUSION: The current results suggest that EBV-transformation of peripheral blood is an efficient tool in genome banking. The EBV-transformed B-cell lines may be a valuable resource of genome in multi-center translational research by the Korean Gynecologic Oncology Group.
B-Lymphocytes
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Cell Line
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Cryopreservation
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Genome
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Genomics
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Herpesvirus 4, Human
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Histocompatibility Testing
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HLA-A Antigens
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Humans
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Leukocytes
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Ovarian Neoplasms
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Viruses
9.Regional disparities in the availability of cancer clinical trials in Korea
Jieun JANG ; Wonyoung CHOI ; Sung Hoon SIM ; Sokbom KANG
Epidemiology and Health 2024;46(1):e2024006-
OBJECTIVES:
Unequal access to cancer clinical trials is an important issue, given the potential benefits of participation for cancer patients. We evaluated regional disparities in access to cancer clinical trials in Korea.
METHODS:
From the Ministry of Food and Drug Safety database, we extracted 2,465 records of all cancer clinical trials approved between January 2012 and April 2023. To measure disparities in cancer clinical trial access, we calculated the ratio of clinical trials open to non-capital areas relative to those open to capital areas. We then analyzed temporal trends in this ratio, which we termed the trial geographical equity index (TGEI).
RESULTS:
Disparities in access to cancer clinical trials, as indicated by the TGEI, did not significantly improve during the study period (regression coefficient, 0.002; p=0.59). However, for phase II/III trials sponsored by global pharmaceutical companies, the TGEI improved significantly (regression coefficient, 0.021; p<0.01). In contrast, the TGEI deteriorated for trials initiated by investigators or those testing domestically developed therapeutics (regression coefficient, -0.015; p=0.05). Furthermore, the increasing trend of TGEI for phase II/III trials sponsored by global companies began to reverse after 2019, coinciding with the outbreak of coronavirus disease 2019 (COVID-19).
CONCLUSIONS
Over the past decade, access to cancer clinical trials has improved in Korea, particularly for phase II/III trials evaluating therapeutics from global companies. However, this increase in accessibility has not extended to trials initiated by investigators or those assessing domestically developed therapeutics. Additionally, the impact of COVID-19 on disparities in clinical trial access should be closely monitored.
10.Prediction of a high-risk group based on postoperative nadir CA-125 levels in patients with advanced epithelial ovarian cancer.
Sokbom KANG ; Tae Joong KIM ; Sang Soo SEO ; Byoung Gie KIM ; Duk Soo BAE ; Sang Yoon PARK
Journal of Gynecologic Oncology 2011;22(4):269-274
OBJECTIVE: We aimed to determine the ideal cut-off of nadir serum CA-125 level for prediction of progression free survival. METHODS: Among 267 patients who achieved complete remission after chemotherapy, the correlation between nadir CA-125 and progression free survival were compared among the subgroups classified according to the distribution of CA-125. The diagnostic odds ratio and area under the receiver operator characteristics curve were compared at various cut-off points. RESULTS: The nadir CA-125 levels did not have prognostic value under 12 U/mL (to 75 percentile). In contrast, they were significantly correlated with progression free survival only when the CA-125 level was greater than 12, which was 75 percentile (p=0.034). In predicting progression free survival <6 and 12 months, the cut-off value of 18 (90 percentile) showed superior diagnostic performance over 10 or 12 U/mL. Compared with patients who showed nadir levels between 0 and 12 U/mL (0 to 75 percentile), those with nadir >18 U/mL showed a hazard ratio of 2.85 (95% confidence interval, 1.70 to 4.76; p<0.001); patients with nadir levels between 18 and 12 U/mL showed a the hazard ratio of 1.68 (95% confidence interval, 1.11 to 2.56; p=0.015) compared with those whose nadir levels were under 12 U/mL. CONCLUSION: The predictive power of the traditional cut-off of 10 U/mL to classify a risk group or to identify high risk patients was unsatisfactory. The optimal diagnostic performance was observed at the cut-off of 18 U/mL and this can be proposed to dichotomize cut-off values to predict outcomes among individual patients.
Disease-Free Survival
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Humans
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Neoplasms, Glandular and Epithelial
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Odds Ratio
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Ovarian Neoplasms
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Prognosis
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Risk Factors