Biomarkers, Tumor ; Diagnosis, Differential ; Humans ; Immunohistochemistry ; Soft Tissue Neoplasms/pathology*

Diagnosis, Differential ; Fibrosarcoma ; congenital ; diagnosis ; pathology ; Humans ; Infant ; Male ; Soft Tissue Neoplasms ; congenital ; diagnosis ; pathology

Chondroma ; diagnosis ; pathology ; surgery ; Female ; Humans ; Middle Aged ; Soft Tissue Neoplasms ; diagnosis ; pathology ; surgery

Diagnosis, Differential ; Humans ; Sarcoma ; pathology ; Soft Tissue Neoplasms ; classification ; genetics ; pathology

Bone Neoplasms ; pathology ; Diagnosis, Differential ; Hemangioendothelioma ; pathology ; Hemangioendothelioma, Epithelioid ; pathology ; Hemangiosarcoma ; pathology ; Humans ; Sarcoma ; pathology ; Skin Neoplasms ; pathology ; Soft Tissue Neoplasms ; pathology ; Vascular Neoplasms ; pathology

Spindle cell hemangioendothelioma is a rare vascular tumor which is presented with subcutaneous nodules and follows a benign indolent course but has a recurrent tendency, and is histologically resembling a cavernous hemangioma and Kaposi's sarcoma. We present a case of spindle cell hemangioendothelioma possessing clinical aggressiveness with painful bony erosion, histologic pleomorphism and mitoses. A 20-year-old man presented with a recurrent painful mass on the left ankle. The mass was dark brown and firm with irregular margins and measured 1.5 cm in diameter, which affected and eroded the underlying medial malleolus of the left tibia. Microscopically, the tumor was composed of cavernous endothelial-lined blood spaces and spindle cellular areas mimicking Kaposi's sarcoma. The spindle cells intermingled with plump epithelioid cells and showed a moderate degree of pleomorphism with occasional mitoses. Immunohistochemically, the spindle cells were focally positive for factor VIII-associated antigen and vimentin, and negative for S-100 protein, desmin, and epithelial membrane antigen.
Adult ; Bone and Bones/pathology ; Case Report ; Hemangioendothelioma/*diagnosis/pathology/ultrastructure ; Human ; Male ; Microscopy, Electron ; Soft Tissue Neoplasms/*diagnosis/pathology/ultrastructure

OBJECTIVE: To analyze the histopathological and imaging features for soft tissue liposarcoma of extremities and to provide guide for clinical diagnosis.
 METHODS: Nine patients with soft tissue liposarcoma of extremities received treatment in Qinghai University Affiliated Hospital from October 2012 to October 2014. The imaging features of CT and MRI as well as the histopathological features were retrospectively analyzed. The pattern, size and border of tumor were observed, and the correlation between the pathological features and the imaging features was analyzed.
 RESULTS: Lower limb lesion was found in 8 patients, including the left lower leg, left and right thigh, respectively. One patient had right upper arm lesion, 1 case had bleeding, and 1 case displayed with calcification and liquefaction performance. The CT examination showed low density shadow and linear separated shadow. The ultrasound examination displayed different intensity fat-like echo. There was short signal intensity on T1 weighted imaging and long signal intensity on T2 weighted imaging in MRI.
 CONCLUSION MRI and other imaging examinations show good performance in detecting the features of soft tissue liposarcoma of extremities, which possess diagnostic value.
Humans ; Liposarcoma ; diagnosis ; pathology ; Magnetic Resonance Imaging ; Retrospective Studies ; Soft Tissue Neoplasms ; diagnosis ; pathology ; Tomography, X-Ray Computed

Myopericytoma is a newly proposed subgroup of perivascular tumors in the World Health Organization classification of soft tissue tumors. In this study, we report a case of a benign myopericytoma with detailed multidetector CT (MDCT) findings in the parotid gland, a location that has not been described for this type of tumor previously. The clinical presentation, imaging features, histopathological and immunohistochemical findings, and the differential diagnosis with other tumors in the parotid gland are described and reviewed.
Adult ; Diagnosis, Differential ; Female ; Humans ; Immunohistochemistry ; Parotid Neoplasms/pathology/*radiography ; Soft Tissue Neoplasms/pathology/*radiography ; Tomography, X-Ray Computed/*methods

OBJECTIVETo study the clinicopathologic features of dendritic fibromyxolipoma for the purpose of differentiating it from other confusable soft tissue neoplasms.

METHODSEight cases of dendritic fibromyxolipoma were obtained and their clinicopathologic features were studied. Immunohistochemistry stains for CD34, bcl-2, vimentin, cytokeratin, EMA, S-100, HHF35 and smooth muscle actin were performed with labeled streptavidin-biotin (SLAB) system on DAKO auto-immunohistochemical stainer.

RESULTSDendritic fibromyxolipoma usually occurrs in middle-aged to elderly men, developing primarily in the subcutis or muscular fascia of the head and neck region, shoulder, back, calf and foot. Grossly, it is well-circumscribed, partly thinly encapsulated lesion with focal mucinous or gelatinous cutting surface. Histologically, all these tumors showed similar histological features., and were characterized by an admixture of mature adipose tissue, spindle and stellate cells, and abundant myxoid stroma with prominent collagenization. The proportion of above elements varied in different tumors or in different areas within the same tumor. One of the pathologic characteristics was the proliferation of spindle cells and stellate cells showing thin cytoplasmic dendritic prolongations. No cytological atypia or mitotic activity could be identified. Furthermore, the lesions were well-vascularized and the vascular elements consisted of small to median-sized and capillary-sized plexiform vessels. Spindle cells were strongly positive for CD34, bcl-2 and vimentin but negative for S-100 protein and epithelial and muscle markers.

CONCLUSIONSDendritic fibromyxolipoma is characterized by clinicopathologic and immunohistochemical features. Based on those features of this tumor, this entity appears to represent a transitional form between spindle cell lipoma and solitary fibrous tumor, and should be distinguished from myxiod liposarcoma and myxoid malignant fibrous histiocytoma. Due to the benign nature of this lesion, simple local excision is curative.

Aged ; Diagnosis, Differential ; Fibroma ; chemistry ; pathology ; Humans ; Immunohistochemistry ; Lipoma ; chemistry ; pathology ; Male ; Middle Aged ; Soft Tissue Neoplasms ; chemistry ; pathology

Bone Neoplasms ; diagnosis ; pathology ; Breast Neoplasms ; diagnosis ; pathology ; Carcinoma, Non-Small-Cell Lung ; diagnosis ; pathology ; Female ; Humans ; In Situ Hybridization, Fluorescence ; methods ; Lung Neoplasms ; diagnosis ; pathology ; Lymphoma ; diagnosis ; pathology ; Soft Tissue Neoplasms ; diagnosis ; pathology