PURPOSE: To evaluate the results of primary cementless total hip arthroplasty (THA)using the Landos Atoll hydroxyapatite (HA)-coated cup and the Euroform HA-coated stem. MATERIALS AND METHODS: Sixty-four primary THA were performed between November 1991 and October 1994, and were followed more than 5 years. Clinical and radiological results were assessed.Also, the evidence of loosening were observed. RESULTS: The mean Harris hip score improved from 57.0 points preoperatively to 88.5 points postoperatively. Of the 64 cases of emoral stems, 54 cases (84.4%) were classified as stable bone-ingrowth ixa tion, and 10 cases (15.6%)as stable fibrous fixation at the last follow-up. The linear wear of polyethylene insert was 1.83 mm (0.14-4.15 mm)and the linear wear rate was 0.23 mm/yr (0.02-0.72 mm/yr).During the follow-up period, revisions were required in 31 cases (48.4%);18 cases (28.1%)had been reoperated upon and 13 cases were (20.3%)awaiting for reoperation. Excessive early osteolysis were observed in 3 cases within 5 year.1 case in those 3 cases underwent cup revision and another 2 cases underwent head and liner change with bone grafting. CONCLUSION: Landos Atoll HA-coated acetabular cup which followed for minimum 5 years reveals 48.4% failure rate.
Acetabulum ; Arthroplasty, Replacement, Hip ; Bone Transplantation ; Durapatite ; Follow-Up Studies* ; Head ; Hip ; Osteolysis ; Polyethylene ; Prostheses and Implants* ; Reoperation

Advanced atherosclerosis is often associated with dystrophic calcification and remodeling of extracellular matrix of vascular wall. Recently many studies have documented a general relationship between calcification and severity of coronary disease, and discussed the feasibility of electron beam computed tomography for detecting and quantifying the coronary artery calcification in the patients. The present study investigated the expression and the localization of osteopontin, one of noncollagenous bone matrix protein, within the calcified coronary arteries. Autopsy-derived coronary artery specimens were scanned and reconstructed to visualize the pattern of coronary calcification using a novel microscopic computed tomography technique. The localization of the osteopontin were evaluated by immunohistochemial stain with LF7. The present study showed that the pattern of coronary calcification is variable and the expression of osteopontin is localized mainly to calcified lesion. The smooth muscle cells in addition to macrophage expressed osteopontin protein in human coronary atherosclerotic plaques. Soluble osteopontin released near to the sites of vascular calcification may represent an adaptive mechanism aimed at regulating the process of vascular calcification.
Aged ; Calcinosis/metabolism ; Coronary Arteriosclerosis/pathology* ; Coronary Arteriosclerosis/metabolism* ; Coronary Vessels/pathology* ; Coronary Vessels/metabolism ; Coronary Vessels/chemistry* ; Female ; Human ; Immunohistochemistry ; Male ; Middle Age ; Sialoglycoproteins/biosynthesis ; Sialoglycoproteins/analysis*

OBJECTIVE: To explore the association of p53 codon 72 polymorphism with endometriosis. METHODS: Two hundred seventy-one women with surgically or histologically diagnosed edometriosis of stage I-IV, and 219 patients with no evidence of endometriosis by laparoscopy or laparotomy served as control. Allele frequencies and genotype distribution of p53 polymorphisms (arginine homozygosity, heterozygosity, and proline homozygosity) in affected women and controls were evaluated. RESULTS: The genotype distributions of p53 codon 72 polymorphisms did not differ significantly between endometriosis group and control group (p=0.086). However, the genotype distributions of p53 codon 72 polymorphisms differ significantly between stage I-II endometriosis group and control group (p=0.043). Proline homozygotes had higher risk for stage I-II endometriosis compared to arginine homozygotes (odds ratio=2.75, p=0.013). CONCLUSION: These results suggest that proline homozygote of p53 codon 72 polymorphism is associated with the risk of minimal or mild stage of endometriosis in the Korean population.
Arginine ; Codon* ; Endometriosis* ; Female ; Gene Frequency ; Genotype ; Homozygote ; Humans ; Laparoscopy ; Laparotomy ; Proline