1.Ovarian teratoma-associated anti-NMDAR encephalitis in a 12-year-old girl
Soe Lwin, MMed Lwin, MMed ; Myat San Yi ; Mardiana Kipli ; Dr ObsGyn ; Woon SY ; Tin Moe Nwe ; Wan Zuraida Wan Azemi
The Medical Journal of Malaysia 2020;75(6):731-733
The association of ovarian teratoma and anti-N-Methyl-Daspartate receptor (anti-NMDAR) is one of the most common
autoimmune encephalitis syndromes and it is a serious and
potentially fatal pathology that occurs in young women. This
case report describes of a pediatric patient with anti-NMDAR
encephalitis. A-12-year-old girl presented with abnormal
behavior for one week came to Emergency Department of
Sarawak General Hospital, Malaysia. She had psychotic
spectrum symptoms including suicidal tendency. She was
diagnosed with anti-NMDAR encephalitis as positive
antibody was seen in her cerebrospinal fluid. She was
treated with Injection Immunoglobulin. She turned out to
have teratoma which was successfully removed later. Her
progress was remarkable after the surgery with the
Immunoglobulin. A multi-disciplinary team involving a
psychiatrist, neurologist and gynaecologist liaised with
intensivist to successfully manage the case and achieve the
good outcome.
2.Unusual variations of the lateral and posterior cords in a female cadaver.
San San THWIN ; Fazlin ZAINI ; Myo THAN ; Soe LWIN ; Maung MYINT
Singapore medical journal 2012;53(6):e128-30
The presence of anatomical variations of the peripheral nervous system often accounts for unexpected clinical signs and symptoms. We report unusual variations of the lateral and posterior cords of the brachial plexus in a female cadaver. Such variations are attributed to a faulty union of divisions of the brachial plexus during the embryonic period. The median nerve lay medial to the axillary artery (AA) on both sides. On the right, the lateral root of the median nerve crossing the AA and the median nerve in relation to the medial side of the AA was likely the result of a faulty development of the seventh intersegmental artery. We discuss these variations and compare them with the findings of other researchers. Knowledge of such rare variations is clinically important, aiding radiologists, anaesthesiologists and surgeons to avoid inadvertent damage to nerves and the AA during blocks and surgical interventions.
Axillary Artery
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innervation
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Brachial Plexus
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abnormalities
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anatomy & histology
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Cadaver
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Female
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Human Body
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Humans
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Median Nerve
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abnormalities
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anatomy & histology
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Middle Aged
3.Leprosy presented as cutaneous erythema.
Fang WANG ; Sonia Kay HWANG ; Hai-yan HUANG ; Juan DU ; Xiao-lan DING ; Soe Lwin MYINT ; Jian-zhong ZHANG
Chinese Medical Journal 2013;126(19):3797-3797
4.Uterine artery pseudoaneurysm: A case of late intraabdominal haemorrhage after caesarean section
Soe Lwin ; Thidar Soe ; Myat San Yi ; Christine Mui Fong Lee ; Sue Marie Cheng Kian Pe ; Tin Moe Nwe
The Medical Journal of Malaysia 2020;75(3):298-300
Uterine artery pseudoaneurysm (UAP) is a rare acquired
vascular malformation associated with vaginal bleeding or
intraabdominal haemorrhage occurring after pelvic surgery.
Pseudoaneurysm may present with delayed, severe
haemorrhage after a seemingly uncomplicated initial
postoperative period. Treatment is therefore necessary to
prevent further complications. We describe here a case of a
32-year-old mother, who presented with abdominal pain and
intraabdominal bleeding, 20 days after Caesarean Section.
Computerised Tomography (CT) scan showed the presence
of haemoperitoneum, suggestive of pseudoaneurysm at the
right cervical artery which was successfully managed with
emergency angiographic embolisation.
5.Profile of various idiopathic inflammatory myopathies at two university hospitals in Yangon, Myanmar
Ohnmar ; Zin Phyu Tun ; Cho Cho Nyunt ; Su Lei Htay ; Soe Lin Oo ; Cho Mar Lwin ; Yin Minn Soe ; Chit Soe ; Win Min Thit
Neurology Asia 2020;25(3):285-291
Objective: to determine the distribution of various idiopathic inflammatory myopathies (IIM) and
their profile at the largest university hospitals in Yangon, Myanmar. Method: It was a hospital based
prospective study recruiting IIM patients admitted to Neurology and Rheumatology ward over a 1.5
year period from September 2017 to February 2019. Results: Among total 51 IIM patients recruited,
62.7% presented to Neurology ward and 37.3% to Rheumatology ward. Overlap myositis (OM)
was the commonest (43%), followed by immune-mediated necrotizing myopathy (IMNM) 27%,
dermatomyositis (DM) 24%, polymyositis (PM) 6%. Among OM, anti-synthetase syndrome (ASS)
was 23%, and among IMNM, anti-SRP positive was 79%. IMNM and PM patients presented more
to neurologists while OM/ASS and DM more to rheumatologists; 82% were females (F:M= 4.6:1).
Mean age of onset of myositis was 40.2 + 17.8 years, and duration of symptoms before presentation
was 10-3,600 days (shortest in anti-SRP and longest in anti-HMGCR myopathy). Myositis antibodies
were positive in 67%. CK range was 40-25,690 U/l, highest in IMNM and lowest in DM. Associated
connective tissue diseases among OM in order of descending frequency were 47% systemic lupus
erythematosus, 24% Sjogren syndrome, 41% scleroderma and 12% rheumatoid arthritis. Associated
cancer identified were one lung cancer in DM, one breast cancer in OM, one buccal cancer in IMNM
cases.
Conclusions: With recent availability of myositis antibody panel and MHC staining in Myanmar, we
have applied current updated classification to describe the first Myanmar data on IIM cases.
6.Novel Mutations inGene in Two Chinese Acne Inversa Families Manifested as Familial Multiple Comedones and Dowling-Degos Disease.
Cheng ZHOU ; Guang-Dong WEN ; Lwin Myint SOE ; Hong-Jun XU ; Juan DU ; Jian-Zhong ZHANG
Chinese Medical Journal 2016;129(23):2834-2839
BACKGROUNDAcne inversa (AI), also called hidradenitis suppurativa, is a chronic, inflammatory, recurrent skin disease of the hair follicle. Familial AI shows autosomal-dominant inheritance caused by mutations in the γ-secretase genes. This study was aimed to identify the specific mutations in the γ-secretase genes in two Chinese families with AI.
METHODSIn this study, two Chinese families with AI were investigated. All the affected individuals in the two families mainly manifested with multiple comedones, pitted scars, and a few inflammatory nodules on their face, neck, trunk, axilla, buttocks, upper arms, and thighs. Reticulate pigmentation in the flexures areas resembled Dowling-Degos disease clinically and pathologically. In addition, one of the affected individuals developed anal canal squamous cell carcinoma. Molecular mutation analysis of γ-secretase genes including PSENEN, PSEN1, and NCSTN was performed by polymerase chain reaction and direct DNA sequencing.
RESULTSTwo novel mutations of PSENEN gene were identified, including a heterozygous missense mutation c.194T>G (p.L65R) and a splice site mutation c.167-2A>G.
CONCLUSIONSThe identification of the two mutations could expand the spectrum of mutations in the γ-secretase genes underlying AI and provide valuable information for further study of genotype-phenotype correlations.
Amyloid Precursor Protein Secretases ; genetics ; DNA Mutational Analysis ; Female ; Hidradenitis Suppurativa ; diagnosis ; genetics ; Humans ; Hyperpigmentation ; diagnosis ; Male ; Membrane Proteins ; genetics ; Middle Aged ; Mutation ; Pedigree ; Skin Abnormalities ; diagnosis ; Skin Diseases, Genetic ; diagnosis ; Skin Diseases, Papulosquamous ; diagnosis
7.Myanmar diabetes care model: Bridging the gap between urban and rural healthcare delivery
Tint Swe Latt ; Than Than Aye ; Ko Ko ; Ye Myint ; Maung Maung Thant ; Kyar Nyo Soe Myint ; Khin Sanda ; Khaing Lwin ; Htet Htet Khin ; Tin Win Aung ; Kyaw Myint Oo
Journal of the ASEAN Federation of Endocrine Societies 2015;30(2):105-117
There has been significant magnitude of problems of diabetes in Myanmar, according to the estimates of
International Diabetes Federation (IDF) and the recent National Survey on the prevalence of diabetes. There has
been a wide gap of equity between the urban and rural healthcare delivery for diabetes. Myanmar Diabetes Care
Model (MMDCM) aims to deliver equitable diabetes care throughout the country, to stem the tide of rising burden of
diabetes and also to facilitate to achieve the targets of the Global Action Plan for the Prevention and Control of
NCDs (2013-2020). It is aimed to deliver standard of care for diabetes through the health system strengthening at all
level. MMDCM was developed based on the available health system, resources and the country's need.
Implementation for the model was also discussed.
8.A summary of the clinical practice guidelines for the management of patients with Peripheral Arterial Disease in Myanmar
Than Than Aye ; Tint Swe Latt ; Khin Mg Lwin ; Win Win Kyaw ; Myint Soe Win ; Moe Wint Aung ; Ko Ko ; Thein Myint ; Yin Yin Win
Journal of the ASEAN Federation of Endocrine Societies 2013;28(2):114-125
Peripheral artery disease (PAD) broadly encompasses vascular diseases caused primarily by atherosclerosis and thromboembolic pathophysiologic processes that alter the normal structure and function of the aorta, its visceral arterial branches, and the arteries of the lower extremity. The aims of the Myanmar clinical practice guidelines for the management of patients with PAD are to assist physicians in selecting the best management strategies for an individual patient with peripheral artery disease with main focus on lower extremity artery disease (LEAD) due to atherosclerosis, to help the physician to make decisions in their daily practice, and to aid in appropriate referrals to specialists. Early detection and treatment guidelines for the treatment of PAD are important to reduce the morbidity and mortality of patients with vascular problems in Myanmar.
Peripheral Arterial Disease
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Practice Guideline
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Myanmar