PURPOSE: This study compared the effect of two oral care agents on preventing stomatitis and discomfort for acute leukemic patients. METHODS: A total of forty patients was enrolled and randomly assigned to sodium bicarbonate or chlorhexidine group. WHO oral toxicity scale was used for measuring stomatitis and Beck's subjective oral discomfort scale for evaluating oral comfort. Data was collected from August 2009 to February 2010. The data was analyzed using Chi-square test, Fisher's exact test, and Mann-Whitney test. RESULTS: Data analyzed was thirty five one. The incidence of stomatitis was 47.4%, 68.8% in sodium bicarbonate and chlohexidine group respectively. The onset of stomatitis was about the 10th and 9th day after chemotherapy initiation, and the duration was 8.0 and 8.67 day respectively. The severity of stomatitis was highest on the 21st day after chemotherapy initiation. There were no statistical differences in the status of stomatitis and the levels of oral comfort during treatment periods. CONCLUSION: Nurses should routinely assess oral cavity and encourage patients to do oral care actively from second to third week after chemotherapy initiation. Also sodium bicarbonate agent can be recommended to for preventing stomatitis.
Chlorhexidine ; Humans ; Incidence ; Mouth ; Sodium Bicarbonate ; Stomatitis

Ion channels and transporters represent two major types of pathways of transmembrane transport for ions. Distinct from ion channels which conduct passive ionic diffusion, ion transporters mediate active transport of ions. In the perspective of biochemistry, ion transporters are enzymes that catalyze the movement of ions across the plasma membrane. In the present review, we selected the Na(+)/HCO3(-) cotransporter (NBC) as an example to analyze the key biochemical and biophysical properties of ion transporters, including stoichiometry, turnover number and transport capacity. Moreover, we provided an analysis of the electrophysiological principles of NBC based on the laws of thermodynamics. Based on the thermodynamical analysis, we showed how the stoichiometry of an NBC determines the direction of its ion transport. Finally, we reviewed the methodology for experimental determination of the stoichiometry of NBC, as well as the physiological significance of the stoichiometry of NBCs in specific tissues.
Electrophysiological Phenomena ; Ion Transport ; Sodium-Bicarbonate Symporters

We experienced three cases of uric acid stone. We treated all these cases sodium bicarbon with nate for systemic alkalization, 1/10 Molar sodium bicarbonate solution for direct irrigation through urethral & ureteral catheter and allopurinol for decreasing uric acid level and combined surgery was done in two cases, including upper ureteral stone & UVJ stone.
Allopurinol ; Molar ; Sodium ; Sodium Bicarbonate ; Ureter ; Uric Acid* ; Urinary Catheters

The present study investigated the effect of immersion in the excipient lime water on the toxic component lectin protein and explained the scientific connotation of lime water detoxication during the processing of Pinelliae Rhizoma Praeparatum. Western blot was used to investigate the effects of immersion in lime water with different pH(pH 10, 11, and 12.4), saturated sodium hydroxide, and sodium bicarbonate solution on the content of lectin protein. The protein compositions of the supernatant and the precipitate after immersing lectin protein in lime water of different pH were determined by the SDS-PAGE method combined with the silver staining technique. The MALDI-TOF-MS/MS technique was used to detect the molecular weight distribution of peptide fragments in the supernatant and precipitate after immersing lectin protein in lime water of different pH, and circular dichroism spectroscopy was used to detect the ratio changes in the secondary structure of lectin protein during the immersion. The results showed that immersion in lime water at pH>12 and saturated sodium hydroxide solution could significantly reduce the content of lectin protein, while immersion in lime water at pH<12 and sodium bicarbonate solution had no significant effect on lectin protein content. The corresponding lectin protein bands and molecular ion peaks were not detected at the 12 kDa position in the supernatant and precipitate after immersing the lectin protein in lime water at pH>12, which was attributed to the fact that lime water immersion at pH>12 could significantly change the ratio of the secondary structure of lectin protein, resulting in irreversible denaturation, while lime water immersion at pH<12 did not change the ratio of the secondary structure of lectin protein. Therefore, pH>12 was the key condition for the detoxication of lime water during the processing of Pinelliae Rhizoma Praeparatum. Lime water immersion at pH>12 could cause irreversible denaturation of lectin protein, resulting in a significant decrease in the inflammatory toxicity of Pinelliae Rhizoma Praeparatum, which played a key role in detoxification.
Lectins ; Pinellia ; Sodium Bicarbonate ; Sodium Hydroxide ; Tandem Mass Spectrometry ; Water

A case of porphyria cutanca tarda is reported, in which the photosensitive cutaneous symptoms developed in association with impaired hepatic function possibly related to chronic consumption of alcohol. Wood's light examination of the urine revealed coral red fluorescence, and qualitative chemical urinalysis was strong positive for uroporphyrin and coproporphyrin. Biopsy of the skin showed subepidermal bulla with festooning arrangement of the naked papillae and basophilic degeneration of the dermis. The patient's favorable response to alkalinization therapy by sodium bicarbonate per os is encouraging, even for a short period's observation. Clinical, histopathological, and biochemical features of this disease are also discussed.
Anthozoa ; Basophils ; Biopsy ; Dermis ; Fluorescence ; Porphyrias ; Skin ; Sodium Bicarbonate ; Urinalysis

OBJECTIVES: To evaluate the effectiveness of sodium bicarbonate dentifrices in reducing gingivitis and tooth abrasiveness and improving tooth gloss, as compared to a conventional fluoride/silica-containing dentifrice. METHODS: In this double-blinded, randomized clinical study with a paralleled design, 73 healthy adult volunteers (age, 18-39 years), with more than 20 teeth were selected and randomly allocated to the following groups: a control group, a 35% baking soda group, and a 65% baking soda group. Professional plaque controls were provided to all subjects and the same control dentifrice was used for 14 days. At baseline, all subjects received an assigned dentifrice and were instructed to brush three times daily. The tooth gloss and gingival bleeding index were measured at baseline, 45, and 90 days. For measuring surface roughness, toothbrushes were replaced with electronic tooth-brushing machines, and the bovine specimen was brushed via 10,000 horizontal shuttle movements. The surface roughness was measured by a confocal laser scanning microscope (CLSM; Carl Zeiss, LSM-5 Pascal, Germany) Each variable was analyzed by the paired t-test, and change in each variable among groups was analyzed by analysis of variance (ANOVA). Reliability of the gloss was analyzed by an intra-class correlation coefficient. RESULTS: Compared to the controls, the 65% sodium bicarbonate dentifrice group showed significant improvement with regard to the tooth gloss for 90 days as well as a significant inhibitory effect on gingivitis; the 35% sodium bicarbonate dentifrice group, however, showed no inhibitory effect on gingivitis. The relative roughness of the tooth surface in the dentifrices of both the sodium bicarbonate dentifrice groups was significantly low. Further, there was no significant difference with the distilled water group. CONCLUSIONS: The sodium bicarbonate dentifrice has an inhibitory effect on gingivitis. Further, this dentifrice showed low abrasiveness and a glossing effect on teeth.
Adult ; Dentifrices* ; Gingivitis* ; Hemorrhage ; Humans ; Sodium Bicarbonate* ; Tooth* ; Volunteers ; Water

Femoral nerve block with tumescent anesthesia is used to perform the radiofrequency ablation of varicose veins. The surgery can be done as day-case. But if recovery from motor block is delayed, it can make hospital discharge difficult. Prolonged femoral nerve blocks with motor blockade of the quadriceps have been noted after the use of bupivacaine. The motor blockade lasted up to 30–40 hours when 15–30 mL of 0.5% bupivacaine was used. However, it was rarely reported in ropivacaine. We report that femoral nerve block with 15 mL of 0.375% ropivacaine induced prolonged motor blockade up to 30 hours.
Anesthesia* ; Bupivacaine ; Catheter Ablation* ; Femoral Nerve* ; Sodium Bicarbonate ; Varicose Veins*

No abstract available.
Acetylcysteine ; Acute Kidney Injury ; Contrast Media ; Sodium ; Sodium Bicarbonate ; Sodium Chloride

BACKGROUND: Postintubational sore throat and hoarseness are usually mild symptoms but they are very common complaints among the patients after endotracheal general anesthesia. In addition, some might have severe discomfort and need invasive procedure to relieve these problems. We tried new method of endotracheal tube cuff filling with local anesthetics to reduce postoperative sore throat and hoarseness and evaluated the results. METHODS: Endotracheal cuff filling was done with air 5 ml in healthy 20 patients (ASA I-II, control group). And in another healthy (ASA I-II) 35 patients, the cuffs were filled with 4% lidocaine 3.5 ml and 8.4% sodium bicarbonate 1.5 ml mixture. After 24 hours following general anesthesia, patients were visited and asked whether there were sore throat or hoarseness, if any, how the degree was. RESULTS: In lidocaine-treated group, the incidence of postintubational sore throat was less compared to control group significantly. There was no difference in incidence of hoarseness between two groups. CONCLUSION: Endotracheal cuff filled with lidocaine and sodium bicarbonate mixture is suggested as an effective protective method that reduces the frequency of postintubational sore throat.
Anesthesia* ; Anesthesia, General ; Anesthetics, Local ; Hoarseness* ; Humans ; Incidence ; Lidocaine* ; Pharyngitis* ; Sodium Bicarbonate* ; Sodium*

BACKGROUND: The administration of rocuronium is associated with severe burning pain on injection that lasts for approximately 10-20 seconds. Injection pain is probably caused by the acidic pH of rocuronium. Mixing rocuronium with 8.4% sodium bicarbonate might neutralize the acidic pH thereby decrease the level of injection pain. This study investigated the appropriate sodium bicarbonate dose for preventing injection pain. METHODS: The study examined 250 patients (aged 20 to 60 years) from ASA I and II groups who scheduled for elective surgery. The patients were divided randomly into five groups. The control group (SB0) received rocuronium 50 mg (5 ml) only and the experimental groups received rocuronium 50 mg mixed with 8.4% sodium bicarbonate 1 (SB1), 2.5 (SB2.5), 5 (SB5), 7 (SB7) ml, respectively. The level of pain was evaluated as the withdrawal response as follows: no movement, 0; hand and wrist movement, 1 point; ipsilateral arm movement, 2 points; and general movement 3 points. RESULTS: The incidence of a withdrawal response was 68% in the control group (SB0). On the other hand, the incidence of a withdrawal response was 38%, 28%, 14% and 12% in the SB1, SB2.5, SB5 and SB7 groups, respectively. The withdrawal response was significantly lower in the experimental groups than in the control group (P < 0.01). In the experimental groups, a significant difference was observed between the SB1 and SB5, SB7 groups. However, there was no significant difference observed between the SB2.5, SB5 and SB7 groups. CONCLUSIONS: Mixing 5 ml of 8.4% sodium bicarbonate with rocuronium 50 mg (5 ml) is the most effective in preventing the injection pain associated with rocuronium during the induction of anesthesia.
Anesthesia ; Arm ; Burns ; Hand ; Humans ; Hydrogen-Ion Concentration ; Incidence ; Sodium Bicarbonate* ; Sodium* ; Wrist