1.The Relationship between Plasma Oxytocin Levels and Social Anxiety Symptoms.
Kang Seob OH ; Eun Jin KIM ; Ju Won HA ; Hee Yeon WOO ; Min Jung KWON ; Dong Won SHIN ; Young Chul SHIN ; Se Won LIM
Psychiatry Investigation 2018;15(11):1079-1086
OBJECTIVE: The pathophysiology of social anxiety disorder (SAD) is not yet well understood, but previous research has suggested that oxytocin is associated with social behavior and may play a role in human anxiety states and anxiety-related traits. The aim of this study was to investigate the possible relationship between social anxiety symptoms and plasma oxytocin levels. METHODS: Twenty-three male patients with SAD and 28 healthy male controls participated in this study. All participants were assessed using the Mini International Neuropsychiatric Interview (MINI) and the Liebowitz Social Anxiety Scale (LSAS). Multivariate regression analysis was performed to identify associations between plasma oxytocin levels and SAD. RESULTS: In multiple regression models, after controlling for age and years of education, we found that higher oxytocin levels were significantly associated with higher total LSAS scores (R²=0.157, coefficient=0.145, 95% CI=-0.0005–0.291, p=0.051) and fear subscale scores (R²=0.134, coefficient=0.083, 95% CI=0.007–0.159, p=0.034) in the SAD group. CONCLUSION: In this study, increased plasma oxytocin levels were associated with higher social anxiety symptoms among SAD patients, but not among controls. This might be because among SAD patients, higher oxytocin (OT) secretion is an insufficient compensatory attempt to reduce social anxiety symptoms.
Anxiety Disorders
;
Anxiety*
;
Education
;
Humans
;
Male
;
Oxytocin*
;
Plasma*
;
Social Behavior
2.Effects of Assertive Training on Interpersonal Relations, Social Behavior, and Psychiatric Symptoms in Patients with a Mental Disorder.
Kuem Sun HAN ; Hee Su IM ; Bo Kyum YANG ; Hae Kyung CHUNG ; Yong Jin SUH
Journal of Korean Academy of Nursing 2005;35(5):896-903
PURPOSE: This study was designed to examine the effects of an assertive training program on interpersonal relations, and psychiatric symptoms in patients with a mental disorder. METHOD: The study employed a quasi experimental design. The subjects included44 patients with a mental disorder, 20 in the experimental group, and 24 in the control group. Data was collected using structured questionnaires over a 3 month period. RESULTS: There were greater significant increases in scores of interpersonal relations and content of communication in the experimental group than the control group. Also, there was a greater significant decrease in the score of psychiatric symptoms in the experimental group than the control group. CONCLUSION: Assertive training has an effect on increasing content of communication and decreasing psychiatric symptoms.
*Social Behavior
;
Social Adjustment
;
Middle Aged
;
Mental Disorders/*rehabilitation
;
Male
;
*Interpersonal Relations
;
Humans
;
Female
;
*Behavior Therapy
;
*Assertiveness
;
Adult
;
Adolescent
3.Valproic Acid Exposure during Early Postnatal Gliogenesis Leads to Autistic-like Behaviors in Rats.
Tamanna Jahan MONY ; Jae Won LEE ; Cheryl DREYFUS ; Emanuel DICICCO-BLOOM ; Hee Jae LEE
Clinical Psychopharmacology and Neuroscience 2016;14(4):338-344
OBJECTIVE: We reported that postnatal exposure of rats to valproic acid (VPA) stimulated proliferation of glial precursors during cortical gliogenesis. However, there are no reports whether enhanced postnatal gliogenesis affects behaviors related to neuropsychiatric disorders. METHODS: After VPA treatment during the postnatal day (PND) 2 to PND 4, four behavioral test, such as open field locomotor test, elevated plus maze test, three-chamber social interaction test, and passive avoidance test, were performed at PND 21 or 22. RESULTS: VPA treated rats showed significant hyperactive behavior in the open field locomotor test (p<0.05). Moreover, the velocity of movement in the VPA group was increased by 69.5% (p<0.01). In the elevated plus maze test, VPA exposed rats expressed significantly lower percentage of time spent on and of entries into open arms more than the control group (p<0.05). Also, both sociability and social preference indices with strangers in the three-chamber social interaction test were significantly lower in the VPA exposed rats (p<0.05). CONCLUSION: Our results suggest that altered glial cell development is another locus at which pathogenetic factors can operate to contribute to the neurodevelopmental disorder.
Animals
;
Anxiety
;
Arm
;
Autistic Disorder
;
Behavior Rating Scale
;
Interpersonal Relations
;
Neurodevelopmental Disorders
;
Neuroglia
;
Rats*
;
Social Behavior
;
Valproic Acid*
4.Effects of the Female Estrous Cycle on the Sexual Behaviors and Ultrasonic Vocalizations of Male C57BL/6 and Autistic BTBR T+ tf/J Mice.
Hyopil KIM ; Junehee SON ; Hyoungseob YOO ; Hakyoo KIM ; Jihae OH ; Daehee HAN ; Yoon HWANG ; Bong Kiun KAANG
Experimental Neurobiology 2016;25(4):156-162
A primary characteristic of autism, which is a neurodevelopmental disorder, is impaired social interaction and communication. Furthermore, patients with autism frequently show abnormal social recognition. In mouse models of autism, social recognition is usually assessed by examining same-sex social behavior using various tests, such as the three-chamber test. However, no studies have examined the ability of male mice with autism to recognize the estrous cycle of female partners. In this study, we investigated the sexual behaviors, especially mounting and ultrasonic vocal communication (USV), of BTBR T+ tf/J (BTBR) mice, which are used as a well-known mouse model of autism, when they encountered estrus or diestrus female mice. As expected, C57BL/6 mice mounted more female mice in the estrus stage compared with the diestrus stage. We found that BTBR mice also mounted more female mice in the estrus stage than female mice in the diestrus stage. Although the USV emission of male mice was not different between estrus and diestrus female mice in both strains, the mounting result implies that BTBR mice distinguish sexual receptivity of females.
Animals
;
Autistic Disorder
;
Diestrus
;
Estrous Cycle*
;
Estrus
;
Female*
;
Humans
;
Interpersonal Relations
;
Male*
;
Mice*
;
Neurodevelopmental Disorders
;
Sexual Behavior*
;
Social Behavior
;
Ultrasonics*
5.The Effectiveness of School Based Short-Term Social Skills Training in Children with Attention-Deficit/Hyperactivity Disorder(ADHD).
Myung Jae PAEK ; Jung Kwang AHN ; So Yun LIM ; Yang Ryul KIM ; Min Hyeon PARK ; Boong Nyun KIM ; Soo Churl CHO ; Min Sup SHIN ; Jae Won KIM ; Hyo Won KIM
Journal of the Korean Academy of Child and Adolescent Psychiatry 2009;20(2):82-89
OBJECTIVES: Children with attention-deficit hyperactivity disorder (ADHD) often have difficulties in social behavior. The aim of this study was to evaluate the effectiveness of a short-term training program for improving social skills, selfperception and attention deficits. METHODS: The subjects were nine children diagnosed with ADHD with (or without) other mental disorders using the Diagnostic Interview Schedule for Children (DISC-ADHD) module. Children were given eight sessions of a social skills training program. Parents of children simultaneously participated in their own training which was designed to support their children's generalization of skills. Assessments included child, parent and teacher ratings of social skills, self-perception and attention deficit at baseline and post-treatment. RESULTS: Social skills training led to significant improvements in child-reported measures of self-esteem, in teacherreported measures of social skills, and in parent-reported measures of attention deficit. CONCLUSION: This study suggests that short-term social skills training programs for children with ADHD may improve their social skills, self-perception and attention deficits.
Appointments and Schedules
;
Child
;
Generalization (Psychology)
;
Humans
;
Mental Disorders
;
Parents
;
Self Concept
;
Social Behavior
6.Influence of home nurture environment on language development and social emotion in children with developmental language disorder.
Guo-Kai LI ; Gui-Hua LIU ; Qin-Fang QIAN ; Pin GE ; Yan-Qin XIE ; Min-Yan YANG ; Zhang-Qiong WANG ; Ping OU
Chinese Journal of Contemporary Pediatrics 2017;19(5):555-559
OBJECTIVETo investigate the influence of home nurture environment on language development and social emotion in children with developmental language disorder (DLD).
METHODSThe 1-3 Years Child Home Nurture Environment Scale, Gesell Developmental Scale, and Infant-Toddler Social and Emotional Assessment Scale were used for the evaluation of 125 children with DLD. A total of 130 children with normal language development matched for age and sex were enrolled as control group.
RESULTSCompared with the control group, the DLD group had a significantly higher proportion of children in a bad home nurture environment and significantly lower scores of all domains of home nurture environment (P<0.05). In children with DLD, the home nurture environment score was positively correlated with the level of language development (r=0.536, P<0.01) and the score of ability domain in social emotion (r=0.397, P<0.01) and was negatively correlated with the scores of the domains of explicit behavior, covert behavior, and imbalance in social emotion (r=-0.455, -0.438, and -0.390 respectively, P<0.01). Home nurture environment had direct influence on language development in children with DLD and affected their language development via the mediating effect of social emotion.
CONCLUSIONSHome nurture environment influences language development and social emotion in children with DLD, and social emotion has a partial mediating effect between home nurture environment and language development.
Child, Preschool ; Emotions ; Environment ; Female ; Humans ; Infant ; Language Development ; Language Development Disorders ; psychology ; Male ; Social Behavior
7.The impact of social norm and susceptibility on drug use among adolescents.
Jie GONG ; Jing ZENG ; Chen XINGIANG ; Fang LI ; Dun-jin ZHOU ; Zeng-zhen WANG
Chinese Journal of Epidemiology 2007;28(10):988-991
OBJECTIVETo investigate the role of knowledge, attitude and perceived social norm on the use of New Type of Drugs (NTD) and to construct the mediated model among these factors.
METHODSWith stratified random group sampling, 3018 students from 3 middle schools, 3 high schools, 3 vocational high schools and a municipal-own university in Wuhan city completed questionnaires under anonymous and voluntary practice. A conceptual model was developed based on Reasoned Behavior Theory. Structural equation modeling (SEM) was used to test the proposed model.
RESULTSThe overall prevalent rate of NTD was 3.28%, with 4.81% for males, 1.94% for females,1.80% for middle school students, 2.91% for general high school students, 7.83% for vocational school students and 3.25% for college students. SEM seemed to have been fixed nicely into the model. Adolescent NTD was significantly predicted by knowledge, attitude, perceived social norm which were all directly affecting or medicated by the susceptibility of drugs.
CONCLUSIONKnowledge, attitude, perceived social norm might increase the risks for NTD use among adolescents, suggesting that preventive education on drug use among adolescents should be paid to improve the knowledge on drugs.
Adolescent ; Adolescent Behavior ; Female ; Health Knowledge, Attitudes, Practice ; Humans ; Male ; Models, Psychological ; Risk Factors ; Social Behavior ; Social Values ; Students ; statistics & numerical data ; Substance-Related Disorders ; psychology
8.Therapeutic Effects of Leuprorelin (Leuprolide Acetate) in Sexual Offenders with Paraphilia.
Jong Hyuk CHOI ; Jae Woo LEE ; Jang Kyu LEE ; Soyeong JANG ; Mi YOO ; Dae bo LEE ; Jeong Won HONG ; Il Suk NOH ; Myung Ho LIM
Journal of Korean Medical Science 2018;33(37):e231-
BACKGROUND: This study examined the clinical effects of leuprolide acetate in sexual offenders with paraphilic disorders evaluated by means of objective psychiatric assessment. METHODS: The subjects of this study were seven sexual offenders who were being treated by means of an injection for sexual impulse control by a court order. They had been diagnosed with paraphilia by a psychiatrist based on the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5) and had been put on probation by the Ministry of Justice between January 2016 and December 2016. RESULTS: After twelve months, we observed significant improvement in symptoms, as decrease of abnormal sexual interest and activity, sexual fantasy, Clinical Global Impression-Severity (CGI-S), and Clinical Global Impression-Impulsivity (GCI-I). There were a mild feminization of the body shape, feelings of fatigue, and mild hot flushes. No other adverse effect was reported. CONCLUSION: These results suggested that the clinical effects of leuprolide acetate in sexual offenders might be an effective treatment and safety strategy.
Criminals*
;
Diagnostic and Statistical Manual of Mental Disorders
;
Fantasy
;
Fatigue
;
Feminization
;
Humans
;
Leuprolide*
;
Paraphilic Disorders*
;
Psychiatry
;
Sexual Behavior
;
Social Justice
;
Therapeutic Uses*
9.Behavioral and Emotional Problems in Children with Nocturnal Enuresis: Results of a Multicenter Study.
Soo Churl CHO ; Jae Won KIM ; Min Sup SHIN ; Jun Won HWANG ; Sang Won HAN ; Kwan Hyun PARK ; Sang Don LEE ; Kyung Do KIM ; Kun Suk KIM ; Hong Jin SUH ; Yoo Sik LEE ; Jae Yong CHUNG ; Young Kyoon KIM ; Du Geon MOON ; Mi Kyung NAMGOONG ; Chang Hee HAN ; Won Yeol CHO ; Young Sik KIM ; Ki Soo PAI ; Jong Guk LEE ; Woo Young CHUNG ; Yee Jin SHIN
Journal of Korean Neuropsychiatric Association 2005;44(6):730-735
OBJECTIVES: The aim of this study was to examine the behavioral and emotional problems associated with nocturnal enuresis in Korean children. METHODS: Three hundred eighteen children with nocturnal enuresis, together with their parents, completed the Child Behavior Checklist (CBCL), Disruptive Behavior Disorder Scale according to DSM-IV (DBDS), Children's Depression Inventory (CDI), State-Trait Anxiety Inventory for Children (STAIC), and Piers-Harris Children's Self-Concept Scale (PHCSC). Ninety-three normal students were selected as the control group. RESULTS: Compared to the normal control group, the mean scores with regard to the withdrawn, social problems, attention problems, delinquent behavior, aggressive behavior, externalizing problems and total problems profiles were significantly higher in the nocturnal enuresis group according to the CBCL results. The nocturnal enuresis group also scored significantly higher in the ADHD and ODD profiles of the DBDS. The nocturnal enuresis group was more depressed and anxious than the control group according to the results of the CDI and STAI. The mean score of the PHCSC was significantly lower in the nocturnal enuresis group when compared to the normal control group. CONCLUSION: The results of this study suggest that children with nocturnal enuresis in Korea have clinically relevant behavioral and emotional problems. The findings support the link between nocturnal enuresis and psychopathology in Korean children.
Anxiety
;
Attention Deficit and Disruptive Behavior Disorders
;
Checklist
;
Child Behavior
;
Child*
;
Depression
;
Diagnostic and Statistical Manual of Mental Disorders
;
Humans
;
Korea
;
Nocturnal Enuresis*
;
Parents
;
Psychopathology
;
Social Problems
10.Association of Increased Amygdala Activity with Stress-Induced Anxiety but not Social Avoidance Behavior in Mice.
Shou-He HUANG ; Wei-Zhu LIU ; Xia QIN ; Chen-Yi GUO ; Qing-Cheng XIONG ; Yu WANG ; Ping HU ; Bing-Xing PAN ; Wen-Hua ZHANG
Neuroscience Bulletin 2022;38(1):16-28
Chronic stress leads to many psychiatric disorders, including social and anxiety disorders that are associated with over-activation of neurons in the basolateral amygdala (BLA). However, not all individuals develop psychiatric diseases, many showing considerable resilience against stress exposure. Whether BLA neuronal activity is involved in regulating an individual's vulnerability to stress remains elusive. In this study, using a mouse model of chronic social defeat stress (CSDS), we divided the mice into susceptible and resilient subgroups based on their social interaction behavior. Using in vivo fiber photometry and in vitro patch-clamp recording, we showed that CSDS persistently (after 20 days of recovery from stress) increased BLA neuronal activity in all the mice regardless of their susceptible or resilient nature, although impaired social interaction behavior was only observed in susceptible mice. Increased anxiety-like behavior, on the other hand, was evident in both groups. Notably, the CSDS-induced increase of BLA neuronal activity correlated well with the heightened anxiety-like but not the social avoidance behavior in mice. These findings provide new insight to our understanding of the role of neuronal activity in the amygdala in mediating stress-related psychiatric disorders.
Amygdala
;
Animals
;
Anxiety/etiology*
;
Anxiety Disorders
;
Avoidance Learning
;
Mice
;
Mice, Inbred C57BL
;
Social Behavior
;
Stress, Psychological/complications*