1.Buerger's Disease of Paratesticular Tissue: A case report.
Soo Im CHOI ; So Young JIN ; Chan Il PARK
Korean Journal of Pathology 1988;22(4):462-466
We report a case of Buerger's disease manifested by a scrotal mass, in view of its rarity. A tender bean sized mass was palpated in the left scrotum of a 34 year-old male heavy smoker, who had a history of right pain two years ago which subsided spontaneously. The left testis with the paratesticular tissue was excised. Vessels of the spermatic cord and epididymis showed microscopic changes of Buerger's disease. The involved arteries and veins revealed a predominantly subacute pattern with granulomatous inflammation and Langhans' type giant cells within the thrombi.
Male
;
Humans
2.Mediastinal Lymphangioma and Chylothorax: Thoracic Involvement of Gorham's Disease.
So Young YOO ; Jin Mo GOO ; Jung Gi IM
Korean Journal of Radiology 2002;3(2):130-132
We report a case of mediastinal lymphangioma associated with Gorham's disease in a 38-year-old man who had suffered recurrent clavicular fractures during a seven-year period. Mediastinal widening associated with osteolysis of the clavicles and the sternal manubrium was revealed by chest radiography, while computed tomography demonstrated a cystic anterior mediastinal mass infiltrating mediastinal fat and associated with osseous destruction of the clavicles and manubrium. Chylothorax recurred during the course of the disease.
Adult
;
Case Report
;
Chylothorax/*complications
;
Human
;
Lymphangioma/*complications/radiography
;
Male
;
Mediastinal Neoplasms/*complications/radiography
;
Osteolysis, Essential/*complications/pathology/radiography
;
Thoracic Vertebrae/*pathology
;
Tomography, X-Ray Computed
3.Nonsurgical treatment of ectopic pregnancy:Local methotrexate injection.
Kae Hyun NAM ; Jeong Jae LEE ; So Young JIN ; Im Soon LEE ; Kwon Hae LEE ; Tai Ho CHO
Korean Journal of Obstetrics and Gynecology 1993;36(5):625-633
No abstract available.
Methotrexate*
4.A case of Meigs' syndrome.
So Hyun PARK ; No Hyun PARK ; Young Ran HAN ; Moon Whan IM ; Jong Hyeok KIM ; Jin Yong LEE
Korean Journal of Obstetrics and Gynecology 1991;34(2):298-303
No abstract available.
Female
;
Meigs Syndrome*
5.A case of Meigs' syndrome.
So Hyun PARK ; No Hyun PARK ; Young Ran HAN ; Moon Whan IM ; Jong Hyeok KIM ; Jin Yong LEE
Korean Journal of Obstetrics and Gynecology 1991;34(2):298-303
No abstract available.
Female
;
Meigs Syndrome*
6.Excess Deaths in Korea During the COVID-19 Pandemic: 2020-2022
So-Jin IM ; Ji-Yeon SHIN ; Duk-Hee LEE
Journal of Preventive Medicine and Public Health 2024;57(5):480-489
Objectives:
Excess deaths, an indicator that compares total mortality rates before and during a pandemic, offer a comprehensive view of the pandemic’s impact. However, discrepancies may arise from variations in estimating expected deaths. This study aims to compare excess deaths in Korea during the coronavirus disease 2019 pandemic using 3 methods and to analyze patterns using the most appropriate method.
Methods:
Expected deaths from 2020 to 2022 were estimated using mortality data from 2015-2019 as reference years. This estimation employed 3 approaches: (1) simple average, (2) age-adjusted average, and (3) age-adjusted linear regression. Excess deaths by age, gender, and cause of death were also presented.
Results:
The number of excess deaths varied depending on the estimation method used, reaching its highest point with the simple average and its lowest with the age-adjusted average. Age-adjusted linear regression, which accounts for both the aging population and declining mortality rates, was considered most appropriate. Using this model, excess deaths were estimated at 0.3% for 2020, 4.0% for 2021, and 20.7% for 2022. Excess deaths surged among individuals in their 20s throughout the pandemic, largely attributed to a rise in self-harm and suicide. Additionally, the results indicated sharp increases in deaths associated with “endocrine, nutritional, and metabolic diseases” and “symptoms, signs, and abnormal clinical and laboratory findings, not elsewhere classified.”
Conclusions
Substantial variations in excess deaths were evident based on estimation method, with a notable increase in 2022. The heightened excess deaths among young adults and specific causes underscore key considerations for future pandemic responses.
7.Lentinula edodes extract inhibits matrix metalloproteinase expression and increases typeⅠprocollagen expression via the p38 MAPK/c-Fos signaling pathway in ultraviolet A and B-irradiated HaCaT keratinocytes
Im-Jung LEE ; Hwan-Jung OH ; Fatih KARADENIZ ; Young-So PARK ; Ran-Hye KIM ; Jin-Hyun JO ; Im-Kyung JUNG ; Byung-Jin JEON ; Chang-Suk KONG
Asian Pacific Journal of Tropical Biomedicine 2021;11(4):164-173
Objective:To determine the effect of Lentinula edodes extract on ultraviolet (UV) A and UVB-induced changes in matrix metalloproteinase (MMP) and typeⅠprocollagen expression using human immortalized HaCaT keratinocytes. Methods:Lentinula edodes ethanol extract (LEE) was obtained by extraction with 80% ethanol for 4 h at 80 ℃. Effect of LEE on UV-induced alteration on the expression and production of MMPs and typeⅠprocollagen in keratinocytes was investigated using ELISA, RT-PCR, and Western blotting assay. To determine the underlying mechanism of LEE-mediated effects, mitogen-activated protein kinase (MAPK) and activator protein 1 signaling pathways were analysed by Western blotting assay. Results:LEE significantly inhibited the expression of MMP-1 and MMP-9 and increased the expression of typeⅠprocollagen in UVA and UVB-irradiated HaCaT keratinocytes. The phosphorylation levels of p38 were significantly inhibited by LEE whereas it did not affect c-Jun N-terminal kinase and extracellular signal-regulated kinase phosphorylation. Suppression of p38 phosphorylation was also accompanied by downregulation of UVA and UVB-induced increase in c-Fos. Conclusions:LEE effectively inhibits the expression of MMP-1 and MMP-9 and increases typeⅠprocollagen production through the p38 MAPK/c-Fos signaling pathway in UVA and UVB-irradiated HaCaT keratinocytes. This findings suggest that Lentinula edodes may be developed as a cosmetic material to suppress UV exposure-mediated skin aging.
8.Spontaneous Ileal Perforation in Very Low Birth Weight Infant without Evidence of Necrotizing Enterocolitis.
So Young CHOI ; Im Jung CHOI ; Sung Mi KIM ; Jin Hwa JUNG ; Gil Hyun KIM ; Chang Mok SON
Journal of the Korean Society of Neonatology 2004;11(1):77-80
Ongoing advances in the treatment of very-low-birth-weight infants have confronted us with a growing number of infants susceptible to acquired illnesses of the gastrointestinal tract. Although necrotizing enterocolitis has been regarded as the major cause of gastrointestinal perforation in preterm infants, the incidence of spontaneous perforation occurred in an apparently normal bowel is increasing. The risk factors for spontaneous intestinal perforation include prematurity, twin pregnancies, perinatal asphyxia, prior use of umbilical artery catheter, use of indomethacin and/or steroid, and bacterial or fungal sepsis. We report a case of spontaneous ileal perforation occurred in very low birth weight infant who was successfully treated with emergency operation.
Asphyxia
;
Catheters
;
Emergencies
;
Enterocolitis, Necrotizing*
;
Gastrointestinal Tract
;
Humans
;
Incidence
;
Indomethacin
;
Infant
;
Infant, Newborn
;
Infant, Premature
;
Infant, Very Low Birth Weight*
;
Intestinal Perforation
;
Pregnancy, Twin
;
Risk Factors
;
Sepsis
;
Umbilical Arteries
9.Study of Hydroxyurea Induced Caspase Activities in Chronic Myelogenous Leukemic Cell Line, K562 cells.
Young Jin LEE ; Rae Kil PARK ; Hong Seob SO ; Ji Sun PARK ; Ji Hyun CHO ; Sam Im CHOI
Korean Journal of Clinical Pathology 2000;20(5):435-441
BACKGROUND: Chronic myelogenous leukemia is a chronic myeloproliferative disorder characterized by leukocytosis with myeloid elements at all stages of differentiation, t(9;22)(q34;q11) and bcr/abl rearrangement. We studied hydroxyurea induced apoptotic changes such as externalization of phosphatidylserine, caspase activities on human chronic myelogenous leukemic cell line, K562 cells. METHODS: K562 cells were grown in RPMI 1640 supplemented with 10% fetal bovine serum and treated hydroxyurea. Viability was examined by MTT assay. Apoptosis were examined by annexin V stain, caspase (such as caspase-, caspase-, caspase-, caspase-, and caspase-) activities, and DNA fragmentation. RESULTS: The viability of K562 cells were markedly decreased in a dose dependent manner of hydroxyurea. Phosphatidylserine externalization was detected by annexin V stain after 3 hours in hydroxyurea treated K562 cells and the value of lactate dehydrogenase was not significantly changed in their culture media. The upstream effector of caspase- was slightly increased and had influenced on caspase-. And downstream acting caspase protease of caspase- was markedly increased in a time dependent manner at hydroxyurea treated K562 cells. In addition, however the activities of caspase- and caspase- were not increased. We also found DNA fragmentation at hydroxyurea treated K562 cells between 48 hours and 72 hours on agarose gel electrophoresis. CONCLUSIONS: Hydroxyurea induces apoptotic change in K562 cells via externalization of phosphatidylserine, activations of caspase-, caspase-, caspase- proteases, and DNA fragmentation.
Annexin A5
;
Apoptosis
;
Cell Line*
;
Culture Media
;
DNA Fragmentation
;
Electrophoresis, Agar Gel
;
Humans
;
Hydroxyurea*
;
K562 Cells*
;
L-Lactate Dehydrogenase
;
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
;
Leukocytosis
;
Myeloproliferative Disorders
;
Peptide Hydrolases
10.Clinical Effects of Oseltamivir in Children with Influenza in Busan, in the First Half of 2004.
Soo Kyoung PARK ; So Young CHOI ; Sung Mi KIM ; Gil Heun KIM ; Jin Hwa JUNG ; Im Jung CHOI ; Kyung Soon CHO
Korean Journal of Pediatrics 2005;48(9):976-985
PURPOSE: Although influenza is one of the most important causes of acute respiratory tract infections in children, effective antiviral therapies are not common and there are only a few clinical studies on treatment of influenza in children. We evaluated the efficacy of oseltamivir in the treatment of naturally aquired influenza in children during the first half of 2004 in Busan. METHODS: From January 2004 to June 2004, throat swabs and nasal washes were performed and cultured for the isolation of influenza virus and tested by rapid antigen detection test (QuickVue influenza test) in children with suspected influenza infections. The children who responded positively to the QuickVue influenza test, we divided into two groups: an oseltamivir treatment group and a control group. We compared their clinical symptoms (including fever duration) and diagnosis. The medical records of patients with influenza virus infection were reviewed retrospectively. RESULTS: A total of 621 individuals were suspected of influenza infection. Influenza viruses were isolated in 79 (17.2 percent) out of 621 patients examined. QuickVue influenza tests were positive in 181 cases. The treatment group (83 individuals) received oseltamivir twice daily for 5 days, and the control group (99 individuals) were administered only symptom relief medicine. There was no differences between the two groups in clinical diagnosis and symptoms. Oseltamivir treatment reduced the fever duration and other respiratory symptoms. There were no adverse events associated with oseltamivir treatment. CONCLUSION: Our data suggest that oral oseltamivir treatment reduces the fever duration and other respiratory symptoms of acute influenza without side effects in children.
Busan*
;
Child*
;
Diagnosis
;
Fever
;
Humans
;
Influenza, Human*
;
Medical Records
;
Orthomyxoviridae
;
Oseltamivir*
;
Pharynx
;
Respiratory Tract Infections
;
Retrospective Studies