No abstract available.
Encephalomyelitis, Acute Disseminated*

We studied the expressions of E-cadherin, MMP-7 and CD44V in colorectal cancer and their corresponding normal mucosa using RT-PCR. From the 26 patients whom a com parative study of clinical and histopathological data is available, MMP-7 and CD44V were significantly enhanced in cancer and their metastatic tissues, compared with their normal mucosa. E-cadherin did not reveal any difference between cancer and normal mucosa. The relashionship between these genes and colorectal cancer development can not be confirmed by this study, however CD44v and MMP-7 may be associated with metastasis of colorectal cancer.
Cadherins ; Cell Line* ; Colorectal Neoplasms* ; Humans ; Mucous Membrane ; Neoplasm Metastasis*

BACKGROUND: Epidural morphine has side effects, especially pruritus, nausea, and vomiting. Butorphanol has been added in studies to reduce these side effects in post cesarean patients. The purpose of this study was to evaluate the side effects and analgesic efficacy when a combination of epidural morphine and butorphanol was administered in patients having combined local anesthetic and opioid epidural infusion. METHODS: Sixty patients having epidural anesthesia for cesarean section were randomly divided into two groups. Group M (n=30) received a bolus of 0.25% bupivacaine 4 ml, morphine 2 mg, and saline 0.75 ml, whereas group B (n=30) received a bolus of 0.25% bupivacaine 4 ml, morphine 2 mg, and butorphanol 1.5 mg (0.75 ml). Continuous epidural infusion was done by Two-day Infusor containing either 0.25% bupivacaine 75 ml, morphine 5 mg, and saline 20 ml in group M or 0.25% bupivacaine 75 ml, morphine 5 mg, butorphanol 4 mg (2 ml), and saline 18 ml in group B. We compared the side effect and analgesic effect of group M to those of group B for 2 days. RESULTS: The incidence of pruritus and vomiting were reduced significantly in group B (p<0.05). There were no significant differences between both groups in the incidence of nausea or other side effects as well as no differences in analgesic effect. CONCLUSIONS: We conclude that the addition of butorphanol to morphine in combined local anesthetic and opioid epidural infusion for postoperative analgesia decreases the occurrence of pruritus and vomiting without significant increase of other side effects and adverse effect on analgesia.
Analgesia ; Anesthesia, Epidural ; Bupivacaine ; Butorphanol* ; Cesarean Section* ; Female ; Humans ; Incidence ; Infusion Pumps ; Morphine* ; Nausea ; Pregnancy ; Pruritus ; Vomiting

BACKGROUND AND OBJECTIVES: The identification of a specific etiology of effusive pericardial disease is difficult because of the limited yield of cytologic and microbiologic pericardial fluid analysis. We performed retrospective study to find out whether pericardial biopsy was superior to pericardial fluid analysis in search of the etiology of pericardial effusion. MATERIALS AND METHOD: We reviewed 76 cases of moderate to severe pericardial effusion on which we performed surgical pericardial biopsy from Sep. 1986 to Sep. 1996. The results of pericardial fluid analysis, clinical manifestation, pericardial biopsy were compared retrospectively. RESULTS: 1)Clinical diagnosis of pericardial effusion were as follow:neoplastic disease (7.9%), tuberculosis (72.4%), constrictive pericarditis (17.1%), and others (2.6%). 2)By the percutaneous pericardial biopsy, we confirmed 19 cases (25%). Etiology of 4 cases (5.3%) were malignancy and 15 cases (19.7%) tuberculosis. Fifteen out of 76 patients who were diagnosed by biopsy as tuberculous pericarditis and 28 patients who were suspected as tuberculous pericarditis clinically were treated with antituberculous medications. Ten patients (66.7%) of pathologically diagnosed patients and 18 patients (69.2%) of clinically diagnosed patients showed complete resolution of pericarditis. CONCLUSION: By pericardial biopsy, we only confirmed 19 cases (25.0%). It means that pericardial biopsy is not superior to pericardial fluid analysis in searching of etiology of pericardial effusion. Moreover, it is not sufficient for final diagnosis of pericardial effusion.
Biopsy* ; Diagnosis ; Humans ; Pericardial Effusion ; Pericarditis ; Pericarditis, Constrictive ; Pericarditis, Tuberculous ; Retrospective Studies ; Tuberculosis

PURPOSE: The purpose of this study was to identify the relationship of stress, perception of occurrence risk of cancer and cancer preventive health behavior in three-shift nurses. METHODS: The participants of this study were 252 three shifts nurses working at three medium and small sized hospitals with 100 to 300 beds. Data were collected through a structured questionnaire from September to October 2014. RESULTS: The mean score for stress was 24.35+/-7.93. The mean score of perception for occurrence risk of cancer was 12.63+/-4.12 and cancer preventive health behavior was 58.07+/-8.87. Stress had a positive relationship with the perception of occurrence risk of cancer (r=.40, p<.001); the perception of occurrence risk of cancer had a positive relationship with the preventive health behavior against it (r=.31, p<.001); and stress had a positive relationship with preventive health behavior against it (r=.33, p<.001). CONCLUSION: The findings show that participants stress levels were high and degrees of perceptions of occurrence risk and cancer preventive health behaviors were low. Significant correlations were found among these variables. On the basis of these findings, development of intervention is required to reduce stress and enhance the perception of occurrence risk of cancer and cancer preventive health behavior among three shifts nurses.
Health Behavior*

No abstract available.
Neonatology

Bone formation by osteoblast may be closely related to the increase in intracellular Ca2+ activity of osteoblast. In order to study the effects of changes in Ca2+ activity of osteoblast-like cell on fracture healing, we changed intracellular Ca2+ activity of osteoblast-like cells by vanadate and verapamil. And the process of fracture healing was observed after injection of the treatment osteoblast-like cells into the fracture site by hematoxylin-eosin (H-E) stain and bromodeoxyuridine (BrdU) stain. The results were as follow: 1) The most effective range of concentration which could facilitate bone formation was 10-6 to 10-5 M. 2) H-E stain showed more abundant osteoblast and osteoid tissues, more active mitotic division of osteoblast, and earlier appearance of chondroblast and chondroid tissue, making the maturation of woven bone faster in the vanadate-treated group than in the control group. The opposite was true in the verapamil-treated group compared with the control group. 3) BrdU labeling index showed more active osteoblastic proliferation in the vanadate-treated than in the control group. The opposite was observed in the verapamil-treated group compared with the control group. From these results, the fracture healing appears to be facilitated and decelerated by vanadate which apparently increase intracellular Ca2+ activity of osteoblast and verapamil which decreases it, repectively. Therefore the change of intracellular Ca2+ activity of osteoblast can be considered to be one of fracture healing mechanisms and expected to be applied for clinical purpose.
Bromodeoxyuridine ; Chondrocytes ; Fracture Healing ; Osteoblasts ; Osteogenesis ; Vanadates ; Verapamil

BACKGROUND: The effect of spinal anesthesia with hyperbaric tetracaine and bupivacaine, with and without 1:1000 epinephrine were studied in 60 patients having perianal operation in the horizontal lithotomy position. METHODS: The 60 patients were divided into four groups(n=15 in each group). Patients in group I and II received 0.5% hyperbaric tetracaine 7 mg(1.4 ml) and normal saline 0.2 ml (group I) or epinephrine 0.2 mg (0.2 ml) (group II) and patients in group III and IV received 0.5% hyperbaric bupivacaine 7 mg (1.4 ml) and normal saline 0.2 ml (group III) or epinephrine 0.2 mg (0.2 ml) (group IV). After intrathecal injection, changes and durations of sensory block, motor block and anal tone block were checked. RESULTS: The sensory block level was similar in four groups and the duration of analgesia was significantly longer in bupivacaine groups (III and IV) than in tetracaine groups (I and II) (in turn, group IV, II, III and I). Tetracaine groups were earlier onset of motor block, a larger number of patients with motor block and significantly longer duration of motor block than bupivacaine groups (in turn, group II, I, IV and III). The onset of anal tone block was earlier in tetracaine groups as the onset of motor block, but the duration of anal tone block was significantly longer in bupivacaine groups as the duration of analgesia (in turn, group IV, II, III and I). Epinephrine 0.2 mg produced significant prolongation of durations of analgesia, motor block and anal tone block of the hyperbaric tetracaine and bupivacaine. Cardiovascular change was similar in four groups and most common complication in all groups after spinal anesthesia was urinary retention. CONCLUSIONS: We conclude that the hyperbaric tetracaine and bupivacaine are appropriate anesthetic agents for perianal surgery and epinephrine produce a significant prolongation of the postoperative analgesic duration in both anesthetic agents.
Analgesia ; Anesthesia, Spinal ; Anesthetics ; Bupivacaine* ; Epinephrine ; Humans ; Injections, Spinal ; Tetracaine* ; Urinary Retention

Subclavian vein cannulation as a central venous route is a simple and rapid beside procedure and most reliable method. The supraclavicular approach to the subclavian vein depended on a fixed entry point and accurate angulation of the needle and is particularly free from infection and phlebitis although catheters have been left in situ for long-term period. Tension pneumothorax is a complication of subclavian vein cannulation. The incidence of pneumothorax in patients with chronic obstructive pulmonary disease(COPD) is higher than in the general population and can result in serious respiratory compromise. Because pneumothorax is a serious complication in COPD, its presence must be anticipated so that close and prompt treatment, including immediate re-expansion of the lung, is offered. Authors presented one case that the patient with COPD developed tension pneumothorax in right side lung resulting from inadvertent lung injury during supraclavicular subclavian vein cannulation under general anesthesia and on trendelenberg position. The patient was treated with immediate thoraeostomy and recovered uneventfully.
Anesthesia, General ; Catheterization* ; Catheters ; Humans ; Incidence ; Lung ; Lung Diseases, Obstructive ; Lung Injury ; Needles ; Phlebitis ; Pneumothorax* ; Pulmonary Disease, Chronic Obstructive* ; Subclavian Vein* ; Veins

Epidural block is useful for chronic pain and thoracic surgery. However, there are several complications, which include vessels or dural puncture, pleural puncture, misplacement of epidural catheter and trauma to the spinal cord. We report a case of intercostal misplacement of an epidural catheter in a 66-year-old patient who scheduled for left thoracotomy.
Aged ; Catheters ; Chronic Pain ; Humans ; Punctures ; Spinal Cord ; Thoracic Surgery ; Thoracotomy