PURPOSE: This study was conducted to develop and test an explanatory model on functional capacity in patients with chronic obstructive pulmonary disease using path analysis. METHODS: Data were collected from 149 chronic obstructive pulmonary disease patients using 6-minute walk test, measurement of oxygen saturation, pulmonary function test, and self-reported questionnaires from June to October, 2005. The collected data were analyzed using SPSS/WIN 12.0 program and AMOS/WIN 4.0 program. RESULTS: The overall fitness indices of modified model were good( chi-square = 14.324, p = .281 GFI = .981, RMSEA = .006, AGFI = .944, NFI = .927, NNFI = .999, CFI = .999, PNFI = .613, chi-square /df = 1.194). Functional capacity was influenced directly by age(beta = -.304, p = .000), dyspnea(beta = -.278, p = .000), self-efficacy(beta = .240, p = .000), social support(beta = .175, p = .004), pulmonary function(beta = .169, p = .008), and oxygen saturation(beta = .099, p = .048). These variables explained 39.3% in functional capacity. CONCLUSION: The findings of this study suggest that comprehensive nursing interventions should focus on decreasing dyspnea and increasing self-efficacy, social support, and oxygen saturation. In this perspective, pulmonary rehabilitation would be an effective strategy for improving functional capacity in patients with chronic obstructive pulmonary disease.
Aminopeptidases ; Dyspnea ; Humans ; Oxygen ; Pulmonary Disease, Chronic Obstructive ; Respiratory Function Tests ; Surveys and Questionnaires

BACKGROUND: This study aimed at assessing the knowledge of the general public about novel influenza and the extent of preventive measures undertaken when information on novel influenza and its preventive measures was extensively broadcasted during the novel influenza outbreak. METHODS: Between September 21 and October 31, self-report questionnaires were distributed to 1,200 persons. The completed questionnaires were collected from 1,025 persons. The collected data was used to determine the frequency and percentage as well as to conduct analyses such as t-test, ANOVA, and logistic regression by using SPSS WIN 12.0. RESULTS: The knowledge on novel influenza and the performance of preventive measures were scored at 6.58 and 5.10, respectively, on a scale of 12. This finding suggested that the knowledge on novel influenza and the performance of preventive measures were low. The significant factors influencing the participants' knowledge on novel influenza were age and the experience of watching relevant educational programs on television, whereas the factors influencing the performance of preventive measures were academic career, working status, and the experience of watching relevant educational programs on television. Between knowledge and implementation of preventive measures, there was positive correlation at low level (r=0.112, P<0.001). CONCLUSION: In conclusion, this study demonstrated that factors influencing the knowledge on and the performance of preventive measures against a disease should be considered when developing prevention strategies, such as broadcast of educational programs on television, against influenza or similar infectious diseases during an outbreak.
Communicable Diseases ; Humans ; Influenza, Human ; Logistic Models ; Pandemics ; Television ; Surveys and Questionnaires

PURPOSE: The purpose of this study was to identify the factors influencing fatigue in patients with chronic obstructive pulmonary disease. METHODS: A descriptive correlational study design was used. A convenience sample of 125 subjects was recruited from the outpatient respiratory clinic at a large university hospital. Data was collected from June to October, 2005 using structured questionnaires, an oxygen saturation test, a 6-minute walking test, and a pulmonary function test. RESULTS: Subjects had a slightly low degree of fatigue. The fatigue showed a significant correlation with emotion(r= .589, p= .000), dyspnea(r= .304, p= .001), self-efficacy (r= -.278, p= .002), and symptom experience(r= .238, p= .008). Emotion(34.7%) and dyspnea(5.8%) were significant predictors to explain fatigue. CONCLUSION: This study provides comprehensive understanding of the influencing factors on fatigue in patients with chronic obstructive pulmonary disease. Nursing interventions to decrease negative emotion and dyspnea for management of fatigue is suggested.
Aged ; Dyspnea/etiology ; Emotions/physiology ; Fatigue/*etiology/psychology ; Female ; Humans ; Male ; Middle Aged ; Oximetry ; Pulmonary Disease, Chronic Obstructive/*complications/physiopathology/psychology ; Questionnaires ; Regression Analysis

PURPOSE: This study was performed to analyse the trends of risk factor management programs for patients with coronary artery disease. METHODS: Using PubMed, 35 intervention studies related to risk factor management programs among randomized controlled trials searched with the key words of coronary artery disease and coronary heart disease. Collected studies were analysed according to the characteristics of studies and participants, method and content of intervention, and outcome indicator and its effects. RESULTS: The mean period of intervention was 28.7+/-26.8 weeks, the mean frequency was 3.0+/-2.0 times per week, and the duration of one session was below 60 minuets in 65.8% of the reviewed studies. The interventions were counselling, exercise, education, and cognitive behavior therapy. Counselling was applied most frequently in previous studies. The outcomes of intervention had been measured with anthropometric, physical, physiological, psychological, behavioral, and cognitive aspects, but the effect of the intervention was inconsistent among the studies. CONCLUSION: Based on the results of this study, systematic and comprehensive cardiac rehabilitation program consisted of counselling, exercise, and education should be developed and performed for health management and relapse prevention of patients with coronary artery disease.
Cognitive Therapy ; Coronary Artery Disease ; Coronary Disease ; Coronary Vessels ; Humans ; Clinical Trial ; Recurrence ; Risk Factors

PURPOSE: The purpose of this study was to develop and test an explanatory model of dyspnea in patients with chronic lung disease (CLD). METHODS: Participants were 181 patients with CLD, recruited from the outpatient pulmonary clinic of one university hospital in Korea. Data were collected using questionnaires, as well as measurement of 6-minute walking distance (6MWD), oxygen saturation (SpO2), FEV1% predicted, and Body Mass Index (BMI). RESULTS: The results indicated a good fit between the proposed dyspnea model and the collected data [chi-square =91.27, p= .13, chi-square/d.f.=1.17, Normal Fit Index= .934]. Oxygenation (SpO2, = -.530), self-efficacy (= -.429), anxiety (= .253), depression (= .224), exercise endurance (6MWD, = -.211), and pulmonary function (FEV1% predicted, = -.178) had a direct effect on dyspnea (all p< .05) and these variables explained 74% of variance in dyspnea. BMI, smoking history, and social support had an indirect effect on dyspnea. CONCLUSION: The findings of this study suggest that comprehensive nursing interventions should focus on recovery of respiratory health and improvement of emotions, exercise ability, and nutritional status. From this perspective, pulmonary rehabilitation would be an effective strategy for managing dyspnea in patients with CLD.
Anxiety ; Body Mass Index ; Depression ; Dyspnea ; Exercise ; Humans ; Korea ; Lung ; Lung Diseases ; Nutritional Status ; Outpatients ; Oxygen ; Surveys and Questionnaires ; Smoke ; Smoking ; Walking

PURPOSE: The purpose of this study was to estimate the effects of an infection control program on the Clonorchis sinensis (CS) infection ratio, CS-related knowledge and health behavior of people living near the Geum River. METHOD: A one-group pretest-posttest design was used with 102 participants. For 12 months the participants were provided with promotion announcements, health education, counseling, and medication. Outcome variables measured were the CS infection ratio by stool examination, CS-related knowledge and health behavior from self-report questionnaires. The pre intervention data were collected from January to February 2008 and the post intervention data during the same period in 2009. Collected data were analyzed using descriptive statistics, generalized estimating equation analysis, and paired t-test with SPSS for Windows version 15.0. RESULTS: In the pre test 21 of the 102 participants showed infection with CS for the first time. In the post test 9 were newly infected with CS, and one was re-infected. The CS-related knowledge was significantly improved after the infection control program (p<0.05). The CS-related health behaviors did not improve. CONCLUSION: These results showed that an infection control program is effective in decreasing CS infection ratio and improving CS-related knowledge of people living near the river.
Clonorchis sinensis ; Counseling ; Geum ; Health Behavior ; Health Education ; Infection Control ; Surveys and Questionnaires ; Rivers

This study was undertaken to investigate the immunological mechanism of Behqet s syndrome, considered to be important in the pathogenesis of the disease. Seventy- three patients with complete, incomplete and suspected types of Behget's syndrotne were tested for leukocyte migration ingibition factor(LIF), one of the lymphokines. The results were as follows : 1. There was no difference between the average LIF activity of all the patients and that of eontrol. 2. LIF activity of complete type, according to Shirnizus classification, was significaritly lower than the control value. 3. LIF activity of ocular type, according to Lehners classification, was signficantly lower than the control value. 4. LIF activity for patients with 4 clinical symptoms was well below the value for patients with less symptomes 5. For patients with single clinical symptom, LIF activity of complete type was well below the values of incomplete and suspected types. 6. In suspected and mucocutaneous types, LIF activity was low when the patients showed two clinical symptoms than one. Thus, LIF activity was low for patients with complete, ocular and neurological types and with multiple symptorns.
Behcet Syndrome* ; Classification ; Humans ; Leukocytes* ; Lymphokines

PURPOSE: This study was to analyze the trend of research on intervention for patients with metabolic syndrome. METHOD: Using Pubmed, Medline, and CINAHL search engines, a randomized controlled trial(RCT) researching titles such as "metabolic syndrome", "intervention", "lifestyle modification", or "community-based" were collected. A total of 16 researches were analyzed based on the guidelines of the National Cholesterol Education Program-Adult Treatment Panel(NCEP-ATP III). RESULTS: 1) The total period of the intervention was from 12 to 24 weeks, the frequency was 3 to 5 times per week, and the duration of each session was from 45 to 60 minutes. The types of intervention included exercise, diet, and medication. Among these types, diet was performed most frequently. 2) The outcomes of the intervention was measured with physical aspects such as anthropometric measures, body composition, or biological markers. No studies have evaluated psychosocial outcomes such as quality of life. 3) In terms of effectiveness of the intervention, anthropometric indicators, body composition, or serological markers showed positive effects, whereas results on endothelial or urine indicators were inconsistent. CONCLUSION: Methodological research developing comprehensive therapeutic lifestyle modification programs and intervention studies are needed for patients with metabolic syndrome. In addition, effects should be evaluated with multidimensional perspectives.
Humans ; Life Style ; Metabolic Syndrome X/*nursing ; *Nursing Methodology Research ; Randomized Controlled Trials as Topic ; Statistics, Nonparametric

PURPOSE: This study was to identify knowledge, perception and health behavior about metabolic syndrome for an at risk group in a rural community area. METHODS: A descriptive cross-sectional survey design was used. A total of 575 adults with hypertension, diabetes mellitus, dyslipidemia, and/or abdominal obesity were recruited from 11 rural community health care centers. A questionnaire was developed for this study. Anthropometric measures were measured and blood data was reviewed from the health record. RESULTS: Knowledge about the metabolic syndrome was low as evidenced by only a 47% correct answer rate. Only 9% of the subjects ever heard about the disease, and 87% answered they do not know the disease at all. 87% of the subjects were not performing regular exercise, 31% drank alcohol more than once a month, 12.5% were current smokers, and 33.6% are did not have a regular health check-up. CONCLUSION: Development of systematic public health care programs are needed to prevent future increases in cardiovascular complications and to decrease health care costs. These might include educational programs for the primary health care provider and an at risk group, a therapeutic lifestyle modification program, and a health screening program to identify potential groups.
Aged ; Anthropometry ; Awareness ; Blood Chemical Analysis ; Cross-Sectional Studies ; Female ; *Health Behavior ; Health Care Surveys ; Health Knowledge, Attitudes, Practice ; Humans ; Life Style ; Male ; Metabolic Syndrome X/etiology/*psychology ; Middle Aged ; *Perception ; Risk Factors ; *Rural Health ; Rural Health Services/organization & administration

BACKGROUND: Flow cytometry analysis of paroxysmal nocturnal hemoglobinuria (PNH) is significantly affected by the methodology used. The lack of data on the effect of age and refrigeration on PNH clone stability motivated us to study these aspects using flow cytometry. METHODS: Peripheral blood was collected from six patients, of which two presented with PNH. All samples were tested immediately and stored at room temperature (RT, 20–25℃) and at 4℃ for re-analysis at 24, 48, 72 hr and 7 days. Anti-CD59-fluorescein isothiocyanate (Beckman Coulter, USA) and anti-CD235a-phycoerythrin (PE; Beckman Coulter) were used to stain red blood cells (RBCs). Fluorescein-labeled proaerolysin (Cedarlane, Canada), anti-CD15-PE (Beckman Coulter), anti-CD24-PE-cyanin 5 (Beckman Coulter), and anti-CD45-PE-cyanin 7 (Beckman Coulter) were used to stain granulocytes. Flow cytometry was performed using a FC500 flow cytometer (Beckman Coulter). The effects of time and temperature were analyzed using generalized estimating equations. RESULTS: No significant differences in the gated percentage of RBCs and PNH clone size of RBCs were observed between the RT and 4℃ groups up to 7 days of testing. The percentage of gated neutrophils decreased with specimen age (P<0.001) and a better correlation with baseline was obtained at 4℃ than at RT (P=0.014). Neutrophil PNH clones were stable until 48 hr and 72 hr at RT and 4℃, respectively, and could not be analyzed at 7 days. CONCLUSIONS: RBC analysis was successfully performed up to 7 days. For neutrophils, testing within 48 hr is recommended, because the number of gated cells decreases significantly with age.
Clone Cells ; Erythrocytes ; Flow Cytometry ; Granulocytes ; Hemoglobinuria, Paroxysmal ; Humans ; Neutrophils ; Refrigeration