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In the present study, immunohistochemical detection of p53 oncoprotein was performed to determine whether the grade of differentiation and the histologic type of gastric adenocarcinoma, and the degree of atypia accompanied with adenoma can be related to p53 mutation. Paraffin sections of 22 gastric adenomas and 56 gastric adenocarcinomas were examined for the overexpression of p53 oncoprotein with the avidin-biotin peroxidase complex staining procedure. The obtained results were as follows; 1. All the 22 cases of adenomas and 16 cases of well differentated adenocarcinomas showed uniformly negative staining. 2.Seven of 18 cases of moderately differentiated adenocarcinomas(39%), and five of 30 cases of poorly differentiated adenocarcinomas(17%) exhibited p53 protein expression. 3. Three of 29 cases of diffuse type (10%) and 9 of 19 cases of intestinal type(47%) exhibited p53 protein expression. These results suggest that p53 mutation is important in carcinogenesis of the intestinal type of gastric adenocarcinoma, and there is no correlation between the differentiation of gastric adenocarcinoma and the degree of p53 oncoprotein overexpression.
Adenocarcinoma ; Adenoma

The thirty four patients(60 eyes) of the same age group, sex and refractive error receiving eximer laser photorefractive keratectomy(PRK) from April 2, 1991 to May 2, 1993 were studied to evaluate the possible factors influencing the myopic regression. In this study, we didn't find any difference between regressed and nonregressed group in the individual parameters such as IOP, keratometer, corneal thickness, occupation, surgeon, hyperopic peak after PRK, and topographic analysis preoperatively and postoperatively. But, the increased tendency of myopic regression one the another eye experiencmg myopic regression on one eye showed statistically significance(P=0.005) and the same tendency was applied on the corneal haziness(P=0.012). We suggest corneal haziness is likely related to causing the myopic regression following PRK. Therefore, the surgeon should particularily try to prevent myopic regression in patients experiencing myopic regression on his one eye by minimizing coneal haziness following PRK.
Humans ; Occupations ; Refractive Errors

Rlsacea is chronic disease of the eye and facial skin, which is common in Caucasian. Ocular rosacea is often difficult for ophthalmologists to diagnose, especially when skin manifestations are not evident yet. Early diagnosis and early treatment is important to prevent its serious complications including corneal opacity and corneal perforation. A case of ocular rosacea in a 52-year-old Korean lady is reported. The patient was presented with hyperemic conjunctiva and vascularization, infiltration and thinning of the peripheral cornea. She did not have any specific skin lesion. But 20 years ago, she had suffered from rosacea. After administation of oral tetracycline and topicale and topical corticosteroid, the signs and symptoms of the ocular rosacea was markedly improved.
Chronic Disease ; Conjunctiva ; Cornea ; Corneal Opacity ; Corneal Perforation ; Early Diagnosis ; Humans ; Middle Aged ; Rosacea* ; Skin ; Skin Manifestations ; Tetracycline*

Rlsacea is chronic disease of the eye and facial skin, which is common in Caucasian. Ocular rosacea is often difficult for ophthalmologists to diagnose, especially when skin manifestations are not evident yet. Early diagnosis and early treatment is important to prevent its serious complications including corneal opacity and corneal perforation. A case of ocular rosacea in a 52-year-old Korean lady is reported. The patient was presented with hyperemic conjunctiva and vascularization, infiltration and thinning of the peripheral cornea. She did not have any specific skin lesion. But 20 years ago, she had suffered from rosacea. After administation of oral tetracycline and topicale and topical corticosteroid, the signs and symptoms of the ocular rosacea was markedly improved.
Chronic Disease ; Conjunctiva ; Cornea ; Corneal Opacity ; Corneal Perforation ; Early Diagnosis ; Humans ; Middle Aged ; Rosacea* ; Skin ; Skin Manifestations ; Tetracycline*

PURPOSES: To evaluate the effect of cycloplegia on the visual acuity and stereopsis according to the refraction and age. METHODS: This study included 112 eyes of 56 patients, which were divided into three groups according to the refraction. The best corrected visual acuity and stereopsis were compared between without and with cycloplegia in all groups according to age. RESULTS: After cycloplegia, at near, naked visual acuity decreased in 0.53 logMAR, average and stereopsis also deceased from 93 seconds to 343 seconds. At far, the naked and best corrected visual acuity had less decreased than near visual acuity. At near, there was no significant difference on the degree of decreased visual acuity and stereopsis according to refraction, but in emmetropic patients, the visual acuity at near significantly decreased. Patients younger than ten years old had more decreased visual acuity at near compared with older than forty-five years old. CONCLUSIONS: After pupil dilatation, there significant decreased near visual acuity and stereopsis, there was little change at far. The degree of decreased vision was different according to the refraction and age, therefore it would be helpful to explain the anticipating result.
Depth Perception* ; Dilatation ; Humans ; Pupil ; Visual Acuity

PURPOSE: To report a patient with malignant conjunctival melanoma with extensive corneal invasive growth. METHODS: A 63-year-old woman with 9 x 7 mm sized dark brown colored conjunctival mass with extensive corneal invasive growth over a 3-month history was seen. The mass was removed and biopsy was done. Fontana-Masson, S-100 protein, and HMB stainings were used to confirm the diagnosis of malignant melanoma. RESULTS: The tumor was easily separated from the corneal surface and adjacent conjunctiva was excised. Fontana-Masson, S-100 protein, and HMB stainings revealed corneally-displaced malignant conjunctival melanoma. There was no evidence of metastasis. CONCLUSIONS: Corneally displaced malignant conjunctival melanoma was very rare. A good surgical result was obtained with its removal.
Female ; Humans ; Biopsy

We retrospectively reviewed the sex distribution, age at oepration, chief complaints, peroperative and postoperative refractive errors, and corrected visual acuity in 160 previously operated patients to evaluate the clinical manifestations, reractive error, frequency of amblyopia, age at operation, and the postoperative factors affected by the operation of epiblepharon and congenital entropion itself that influence visual acuity and refractive error. The average age at operation was 7.9 years. The chief complaint was ocular discomfort, followed by visual disturbance, photophobia, eyelid rubbing and epiphora. One hundred thirty-three wyws(41.6%) whose preoperative corrected visual acuity was below 0.6 had a mean visual acuity of 0.7. Ninety-five eyes (29.7%) were preoperative myopes above -1.0D, 77 eyes(24%) were hyperopes above +1.0D, and 163 eyes were astigmatic above -1.0D. Twenty-two out of 76 eyes who were followed up for more than one year had a corrected visual acuity of below 0.6. The difference between the older and less than 7 years groups was significantly not significant. Astigmatic changes were not statistically different at any age group. However, the mean significantly visual acuity at postoperative one year was 0.73, which was significantly different from the preoperative value(P=0.006). In conclusion, concurrent postoperative glasses correction and amblyyopia therapy is indicated because the incidence of refractive errors and amblyopia is higher in epiblepharon and congenital entropion.
Amblyopia ; Entropion* ; Eyeglasses ; Eyelids ; Glass ; Humans ; Incidence ; Lacrimal Apparatus Diseases ; Photophobia ; Refractive Errors ; Retrospective Studies ; Sex Distribution ; Visual Acuity

PURPOSE: To study the microscopic anatomic relation of capsulopalpebral fascia, orbital septum, and tarsus of the lower eyelid in Korean. METHODS: Foureteen normal Korean lower eyelids from 14 formalin-fixed cadavers (mean age of 66.5 years) were harvested and studied with light microscopy after staining with hematoxylin and eosin. Dimensions of the structures and distances between them was measured by analyzing the digital photographs. RESULTS: There was no fusion of the orbital septum and the capsulopalpebral fascia at the lower border of the tarsal plate in 10 specimens and limited fusion of these tissue in 4 specimens. The average distance from the inferior tarsal border to the first identifiable smooth muscle nuclei of the inferior tarsal muscle was 1.38 mm. The average tarsal plate thickness was 0.98 mm and the average tarsal plate height was 3.96 mm. CONCLUSIONS: The Korean lower lid anatomy differs from that of their non-Asian counter parts. Furthermore, there was a difference in tarsal plate thickness in comparison to Chinese lower lids. There was no consistent fusion between the capsulopalpebral fascia and the orbital septum. No extension of the capsulopalpebral fascia to the skin was observed.
Ankle ; Asian Continental Ancestry Group ; Cadaver ; Eosine Yellowish-(YS) ; Eyelids* ; Fascia ; Hematoxylin ; Humans ; Microscopy ; Muscle, Smooth ; Orbit ; Skin

Fetus in fetu is a very rare congenital abnormality in which one vertebrate fetus is enclosed within the abdomen of another fetus. With advancing ultrasound imaging technique, a few case of prenatal diagnosis is reported recently. A case of fetus in fetu with 6 X 6 X 4 cm sized cystic mass in the fetal retroperitoneum was diagnosed prenatally using ultrasound and confirmed by ultrasound and computer tomogram after delivery. This mass was removed completely from delivered baby and finally confirmed fetus in fetu by pathologic examination. Solid portion in this mass was composed of vertebral organization with limb bud, well-developed organ system.
Abdomen ; Congenital Abnormalities ; Fetus* ; Limb Buds ; Prenatal Diagnosis* ; Ultrasonography ; Vertebrates