OBJECTIVE: To investigate the usefulness and indications of arthrosonography by testing if the new technique could provide additional information on the degrees of rotator cuff tears when compaired to the findings of conventional ultrasonographic examinations. METHOD: Thirty six patients, who were identified to have partial or full-thickness rotator cuff tears by conventional ultrasonography, were included. Intraarticular injection of 15 ml of fluid was performed via posterior approach under ultrasound-guidance, which was followed by arthrosonography. RESULTS: Among 26 patients with partial-thickness tear which was detected by the conventional ultrasonography, eight were identified to have full-thickness tears by the arthrosonography. Although the difference was not significant, the grade 3 partial-thickness tear in the conventional sonography had a higher rate of being identified as full- thickness tear in the arthrosonography than the grade 2 partial-thickness tears. The size of partial-thickness tear was increased after instillation of fluid in the arthrosonography. CONCLUSION: Arthrosonography would be useful in differentiating partial- and full-thickness tears. When a tear of the rotator cuff tendon, especially a grade 3 partial-thickness tear, is detected in the conventional sonographic examination, an obscured full-thickness tear should be suspected and subsequent arthrosonographic procedure could be administered to clarify the extent of the lesion. Moreover, arthrosonography might be helpful in detecting partial-thickness tears by making them appear larger after instillation of fluid.
Humans ; Injections, Intra-Articular ; Rotator Cuff* ; Tendons ; Ultrasonography

PURPOSE: The purpose of this study was to evaluate bone formation around recombinant human bone morphogenetic protein (rhBMP-2)-coated implants placed with or without absorbable collagen sponge (ACS) in rabbit maxillary sinuses. METHODS: The Schneiderian membrane was elevated and an implant was placed in 24 sinuses in 12 rabbits. The space created beneath the elevated membrane was filled with either blood (n=6) or ACS (n=6). In the rabbits in which this space was filled with blood, rhBMP-2-coated and non-coated implants were alternately placed on different sides. The resulting groups were referred to as the BC and BN groups, respectively. The AC and AN groups were produced in ACS-grafted rabbits in the same manner. Radiographic and histomorphometric analyses were performed after eight weeks of healing. RESULTS: In micro-computed tomography analysis, the total augmented volume and new bone volume were significantly greater in the ACS-grafted sinuses than in the blood-filled sinuses (P<0.05). The histometric analysis showed that the areas of new bone and bone-to-implant contact were significantly larger in the AC group than in the AN group (P<0.05). In contrast, none of the parameters differed significantly between the BC and BN groups. CONCLUSIONS: The results of this pilot study indicate that the insertion of ACS after elevating the Schneiderian membrane, simultaneously with implant placement, can significantly increase the volume of the augmentation. However, in the present study, the rhBMP-2 coating exhibited limited effectiveness in enhancing the quantity and quality of regenerated bone.
Bone Morphogenetic Protein 2 ; Bone Morphogenetic Proteins ; Collagen* ; Dental Implants ; Humans ; Maxillary Sinus ; Membranes ; Nasal Mucosa ; Osteogenesis* ; Pilot Projects ; Porifera* ; Rabbits ; Sinus Floor Augmentation ; Transplants* ; X-Ray Microtomography

OBJECTIVE: To investigate the relationship between the rotator cuff tear (RCT) and the muscle strength in hemiplegic side, and the effects of paralysis on the affected shoulders in hemiplegic patients. METHODS: A cross-sectional observational study performed in a university hospital was presented. The study enrolled 55 participants with hemiplegia of diverse degree of motor paresis, excluding those with bilateral lesions, history of major trauma or other co-existing musculoskeletal disorders of the shoulder. The main outcome measurements were muscle strength of the affected upper extremity (based on Medical Research Council scale), RCTs of the bilateral shoulders (by ultrasonography), and presence of shoulder pain, subluxation of the glenohumeral joint, passive range of motions, and subacromial spurs. RESULTS: Comparing each side of the shoulders, the prevalence of shoulder pain and supraspinatus muscle tear was higher (p<0.0001, p=0.007), and the range of motion was restricted (p<0.0001, p<0.0001, p<0.0001, p<0.0001) in the affected side. There was a significant trend toward higher prevalence of RCT and shoulder subluxation in the weaker shoulder (p=0.019, p<0.0001). In a multivariate analysis, Manual Muscle Test grade of less than three was an independent risk factor for RCT (p=0.025). CONCLUSION: RCT in hemiplegia had a linear trend with muscle weakness in the affected side and the degree of weakness was an independent risk factor for the occurrence of RCT. In addition, shoulder pain, limitation of range of motions, and RCT were more frequent on the hemiplegic side of the shoulders. It is the first study to reveal a linear trend between RCT and upper extremity weakness and will provide physicians an insight to the management of RCTs in hemiplegic patients.
Hemiplegia ; Humans ; Multivariate Analysis ; Muscle Strength ; Muscle Weakness ; Muscles ; Paralysis ; Paresis ; Prevalence ; Range of Motion, Articular ; Risk Factors ; Rotator Cuff ; Shoulder ; Shoulder Joint ; Shoulder Pain ; Tendon Injuries ; Upper Extremity

Systemic lupus erythematosus (SLE) is an autoimmune disease which may affect different organs and disclose various clinical manifestations. The clinical manifesations of central nervous system involvement in SLE are highly variable and range from mild cognitive dysfunction, movement disorder, headache, psychosis to life-threatening stroke and coma. Among neuropsychiaric disorders encountered in patients with SLE, cerebrovascular disease has relatively been rare complication. We experienced a case of subdural hematoma (SDH) occurring in a SLE patient which presented with headache. She was diagnosed as SDH by neuropsychiatric symptoms, brain CT, and brain MRI, and showed good response to medical treatment.
Autoimmune Diseases ; Brain ; Central Nervous System ; Coma ; Headache ; Hematoma, Subdural* ; Humans ; Lupus Erythematosus, Systemic* ; Magnetic Resonance Imaging ; Movement Disorders ; Psychotic Disorders ; Stroke

PURPOSE: Recently, single-incision laparoscopic surgery (SILS) has been popular for minimally invasive surgery and cosmetic improvement. However, some papers have reported that SILS for an appendectomy (SILS-A) has had the more postoperative complaints of pain. We investigated postoperative pain relief using wound infiltration with 0.5% bupivacaine in SILS-A and compared the result with that for conventional SILS-A. METHODS: Between July 2010 and September 2012, 75 patients who underwent SILS-A were enrolled in this study. The patients were randomly assigned to two groups: conventional SILS-A group (C-SILS-A) or wound infiltrated with 0.5% bupivacaine in SILS-A group (W-SILS-A). Forty-five patients were in the C-SILS-A, and 30 patients were in the W-SILS-A. Patients with perforated appendicitis were excluded. The clinical outcomes were compared between the groups by using the verbal numerical rating scale (VNRS). RESULTS: Clinical outcomes were similar in both study groups except for the pain score. The W-SILS-A group showed significantly lower numbers of additional pain killers and lower VNRS scores 1, 6, and 12 hours after surgery than the C-SILS-A group. CONCLUSION: W-SILS-A is a technically simple and effective method of reducing early postoperative pain. It may be applicable in SILS-A for pain control system.
Appendectomy* ; Appendicitis ; Bupivacaine* ; Humans ; Laparoscopy* ; Methods ; Pain, Postoperative* ; Wounds and Injuries*

OBJECTIVE: To investigate the musculoskeletal cause of hemiplegic shoulder pain using ultrasonographic evaluation of hemiplegic shoulder. METHOD: Thirty-six hemiplegic patients admitted to rehabilitation department were enrolled. Ultrasonographic investigation of shoulder and physical examinations including range of motion (ROM), muscle power, spasticity and subluxation of shoulders were performed. RESULTS: Eighteen (55.6%) patients reported pain in hemiplegic shoulder. The abnormal sonographic findings, ROM, muscle power, spasticity, and subluxation of hemiplegic shoulder were not significantly different between subjects with painful hemiplegic shoulder and those without. The presence of ultrasonographic abnormality combined with focal tenderness, however, was significantly related with the painfulness of hemiplegic shoulder (p-value = 0.03). CONCLUSION: These results suggest that ultrasonographic evaluation is useful to investigate the musculoskeletal component of painful hemiplegic shoulder, when collaborated with physical examination of focal tenderness.

The authors recently found a mistake in their previously published article and sincerely regret these errors.

Purpose: We aimed to assess the humoral response to and reactogenicity of coronavirus disease 2019 (COVID-19) vaccination according to the vaccine type and to analyze factors associated with immunogenicity in actively treated solid cancer patients (CPs). Materials and Methods: Prospective cohorts of CPs, undergoing anticancer treatment, and healthcare workers (HCWs) were established. The participants had no history of previous COVID-19 and received either mRNA-based or adenovirus vector–based (AdV) vaccines as the primary series. Blood samples were collected before the first vaccination and after 2 weeks for each dose vaccination. Spike-specific binding antibodies (bAbs) in all participants and neutralizing antibodies (nAbs) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) wild-type, Delta, and Omicron variants in CPs were analyzed and presented as the geometric mean titer. Results: Age-matched 20 HCWs and 118 CPs were included in the analysis. The bAb seroconversion rate and antibody concentrations after the first vaccination were significantly lower in CPs than in HCWs. After the third vaccination, antibody levels in CPs with a primary series of AdV were comparable to those in HCWs, but nAb titers against the Omicron variant did not quantitatively increase in CPs with AdV vaccine as the primary series. The incidence and severity of adverse reactions post-vaccination were similar between CPs and HCWs. Conclusion CPs displayed delayed humoral immune response after SARS-CoV-2 vaccination. The booster dose elicited comparable bAb concentrations between CPs and HCWs, regardless of the primary vaccine type. Neutralization against the Omicron variant was not robustly elicited following the booster dose in some CPs, implying the need for additional interventions to protect them from COVID-19.