1.Liver Cirrhosis Due to Autoimmune Hepatitis Combined with Systemic Sclerosis.
Byung Chul YOU ; Soung Won JEONG ; Jae Young JANG ; So Mi GOO ; Sang Gyune KIM ; Young Seok KIM ; Chan Hong JEON ; Yoon Mi JEEN
The Korean Journal of Gastroenterology 2012;59(1):48-52
Systemic sclerosis (SSc) is a chronic systemic disease that affects the skin, lungs, heart, gastrointestinal tract, kidneys, and musculoskeletal system. Although up to 90% of patients with scleroderma have been estimated to have gastrointestinal involvement, liver disease has been reported only rarely. A 51-year-old woman was hospitalized due to esophageal variceal bleeding. Her serum was positive for anti-nuclear antibody and anti-centromere antibody. Sclerodactyly was noted on both hands, and she had recently developed Raynaud's syndrome. Punch biopsy of the hand showed hyperkeratosis, regular acanthosis, and increased basal pigmentation in the epidermis, and thick pale collagenous bundles in the dermis. Liver biopsy showed chronic active hepatitis with bridging fibrosis. Consequently, she was diagnosed with liver cirrhosis due to autoimmune hepatitis (AIH) combined with SSc. AIH had subsided after administration of prednisolone at 40 mg per day. She received 5-10 mg/day of prednisolone as an outpatient, and her condition has remained stable. Patients with either AIH or SSc should be monitored for further development of concurrent autoimmune diseases. The early diagnosis of AIH combined with SSc will be helpful in achieving optimal management.
Anti-Inflammatory Agents/therapeutic use
;
Antibodies, Antinuclear/blood
;
Esophageal and Gastric Varices
;
Female
;
Gastrointestinal Hemorrhage
;
Hepatitis, Autoimmune/complications/*diagnosis/drug therapy
;
Humans
;
Liver Cirrhosis/*diagnosis/etiology/pathology
;
Middle Aged
;
Prednisolone/therapeutic use
;
Raynaud Disease/diagnosis
;
Scleroderma, Systemic/complications/*diagnosis
;
Skin/pathology
2.Association of 5-HT3A receptor Pro16Ser polymorphism with the incidence of PONV and the response to ondansetron in Korean patients.
Eui Kyoung GOO ; Jung Won HWANG ; Eun SONG ; Yun Mi SO ; Junghee RYU ; Young Tae JEON ; Sang Hwan DO ; In Jin JANG
Anesthesia and Pain Medicine 2008;3(4):255-259
BACKGROUND: Postopertative nausea and vomiting (PONV) are frequent and distressing side effects of surgery. Even though many drugs has been developed, PONV still remains unsolved problem. Ondansetron is a commonly used 5-HT3 receptor antagonist. It acts through specific binding to the 5-HT3A, 5-HT3B receptor complex. We hypothesized that patients with genetic variation in 5-HT3A receptor might have variable incidence of PONV and respond differently to ondansetron. METHODS: We included 204 patients undergoing gynecologic laparoscopic surgery. PONV were documented during 24 hours after operation. Ondansetron was injected to every patient who had PONV at PACU and PONV reassessed after 15 minutes. DNA was extracted from blood and 5-HT3A Pro16Ser missense mutation was analyzed by using real-time PCR. RESULTS: The incidence of PONV were 50% for wild type, 53% for heterozygote and 0% for homozygote. There were no significant differences between wild type and heterozygote in VAS of nausea and VAS change after ondansetron. CONCLUSIONS: 5-HT3A receptor Pro16Ser polymorphism is not associated with the incidence of PONV and the response to ondansetron in Korean patients.
DNA
;
Genetic Variation
;
Heterozygote
;
Homozygote
;
Humans
;
Incidence
;
Laparoscopy
;
Mutation, Missense
;
Nausea
;
Ondansetron
;
Postoperative Nausea and Vomiting
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Real-Time Polymerase Chain Reaction
;
Receptors, Serotonin, 5-HT3
;
Vomiting
3.A case of dyke-davidoff-masson syndrome associated with hypopituitarism and diabetes mellitus.
So Yeon PARK ; Mi Young LEE ; Jae Hyun KIM ; Song Yi KIM ; Jang Yel SHIN ; Young Goo SHIN ; Choon Hee CHUNG
Korean Journal of Medicine 2010;79(3):316-320
Dyke-Davidoff-Masson syndrome (DDMS) is a rare condition characterized by asymmetric cerebral hemispheric growth with unilateral atrophy, ipsilateral compensatory osseous hypertrophy, hyperpneumatization of the paranasal sinuses and mastoid cells, and contralateral paresis. Varying degrees of hemiparesis, hemiplegia, seizures, mental retardation, and facial asymmetry can be associated with DDMS. We report the case of a 26-year-old man with DDMS associated with hypopituitarism who complained of polydipsia and polyuria. After an oral glucose tolerance test, he was diagnosed with type 2 diabetes. There is no report of DDMS associated with other pituitary dysfunction or hyperglycemia. Clinicians should consider the possibility of coexisting pituitary dysfunction or type 2 diabetes in patients with DDMS, as it is obviously important for the patient's outcome.
Adult
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Amides
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Atrophy
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Diabetes Mellitus
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Facial Asymmetry
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Glucose Tolerance Test
;
Hemiplegia
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Humans
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Hyperglycemia
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Hypertrophy
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Hypopituitarism
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Intellectual Disability
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Mastoid
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Paranasal Sinuses
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Paresis
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Polydipsia
;
Polyuria
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Seizures
;
Sulfones
4.A Case of Surgically Treated Insulinoma in Pregnancy.
Kwan Woo LEE ; Euy Young SOH ; Young Goo SHIN ; Sung Keun LEE ; So Yun PARK ; Sung Kyu LEE ; Yun Suk CHUNG ; Hyun Man KIM ; Kyung Joo HWANG ; Yun Mi JIN
Journal of Korean Society of Endocrinology 1998;13(2):288-294
Insuliin secreting tumor is 70% prevalent disease in female and predoadnant in forth and sixth deeade. The incidence of insulinoma is one case per 250,000 patient-years. Insulinoma in pregnancy was extremely rare, and the prevalence was not reported. The diagnosis of an insulinoma is depend on demonstration of hypoglycemia with high insulin and C-peptide levels. Immunoreactive insulin/plasma glucose ratio0.3 in particular support the diagnosis of an insulinoma. Fetal complication would be developed because of hypoglycemia. In approximately half of the cases reported, surgical exploration was done during pregrancy, the remainder were treated after delivery. Insulinoma poses serious diagnostic and therapeutic problems when she is pregnant. We experienced a case of insulinoma in pregnancy that represented Whipples triad and was treated by surgical intervention.
C-Peptide
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Diagnosis
;
Female
;
Glucose
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Humans
;
Hypoglycemia
;
Incidence
;
Insulin
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Insulinoma*
;
Pregnancy*
;
Prevalence
5.Effect of midazolam premedication on the onset of propofol and rocuronium during propofol target-controlled infusion.
Eui Kyoung GOO ; Cheol Hee JUNG ; Hwan Hee KIM ; Yun Mi SO ; Hyo Seok NA ; Hee Pyoung PARK ; Young Tae JEON ; Jung Won HWANG
Korean Journal of Anesthesiology 2009;57(4):434-437
BACKGROUND: This clinical study was designed to evaluate the effect of midazolam as a premedication on the onset of propofol and rocuronium during propofol target-controlled infusion (TCI). METHODS: Seventy four patients (ASA class I or II) were randomly allocated to receive either no premedication (control group) or premedication with 0.04 mg/kg intravenous midazolam (midazolam group). Anesthesia was induced and maintained with propofol TCI. Time from propofol injection to loss of consciousness (LOC) and estimated effect concentration at LOC were recorded. After LOC, rocuronium (0.6 mg/kg) was injected. We monitored the degree of neuromuscular blockade by acceleromyography. The following parameters were measured and compared between groups: Time from rocuronium injection to depression of twitch height below 25%, time to maximal depression of twitch height (defined as rocuronium onset time). RESULTS: Systolic blood pressure before induction was lower in midazolam group (125 +/- 15 vs 135 +/- 20 mmHg), however, there was no difference in blood pressure at LOC between groups (111 +/- 16 vs 106 +/- 21 mmHg). In midazolam group, time to LOC in propofol TCI was shorter (63 +/- 22 vs. 203 +/- 118 sec) and estimated effect site concentration of propofol was significantly lower than control group (0.9 +/- 0.3 vs. 2.2 +/- 0.4 microl/ml). The onset time of rocuronium was not different between groups (120 +/- 39 vs. 137 +/- 42 sec). CONCLUSIONS: Midazolam pretreatment fastens the onset time of propofol and decreases the propofol requirement for LOC. However, it does not influence the onset of rocuronium.
Androstanols
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Anesthesia
;
Blood Pressure
;
Depression
;
Humans
;
Midazolam
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Neuromuscular Blockade
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Premedication
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Propofol
;
Unconsciousness
6.Evaluation of Fasting Plasma Glucose as a Screening for Diabetes Mellitus in Middle-aged Adults of Naju Country.
Jin Hwa KIM ; Mi Ah HAN ; Chol Jin PARK ; Il Goo PARK ; Ji Hye SHIN ; Sang Yong KIM ; So Yeon RYU ; Hak Yeon BAE
Korean Diabetes Journal 2008;32(4):328-337
BACKGROUND: The criteria for the diagnosis of diabetes mellitus have been modified by the American Diabetes Association (ADA) in 1997. The ADA proposed that the diagnosis of diabetes be defined by a fasting plasma glucose (FPG) of 7.0 mmol/L. Disagreement has been reported between criteria based on FPG and postchallenge 2-h plasma glucose (2-h PG). The aim of the present study is to assess the FPG criteria as the diagnostic screening test for diabetes in Korean middle-aged adults in comparison to the 2-h PG criteria. METHODS: Randomly selected 1,731 subjects (679 men and 1,052 women) aged 40~70 years (mean age: 58.4 +/- 7.89 years) without previously diagnosed diabetes completed 75 g oral glucose tolerance test (OGTT). We assessed the prevalence of diabetes mellitus and the level of agreement (kappa statistics) according to the different diagnostic glucose categories. RESULTS: The frequency of newly diagnosed diabetes was 2.7% (n = 51) using the FPG criteria only; 6.4% (n = 120) using the 2-h PG criteria only; and 6.9% (n = 130) using concentrations of > or = 7.0 mmol/L for FPG or > or = 11.1 mmol/L for 2-h PG. Of the 120 subjects with diabetes by the 2-h PG criteria, 65.8% (n = 79) were not diagnosed with diabetes according to FPG concentration. The level of agreement between two diagnostic criteria was low (kappa = 0.268). The receiver operating characterstic (ROC) curve analysis determined FPG of 5.6 mmol/L to yield optimal sensitivity and specificity corresponding to 2-h PG 11.1 mmol/L. CONCLUSION: The findings in this study demonstrate that the discordance between the FPG and 2-h PG criteria in the diagnosis of diabetes in Korean middle-aged adults is large. We suggest that IFG group (FPG 5.6~6.9 mmol/L) were performed 75 g OGTT for diagnosing diabetes mellitus in Korean middle-aged adults.
Adult
;
Aged
;
Diabetes Mellitus
;
Diabetes Mellitus, Type 2
;
Fasting
;
Glucose
;
Glucose Tolerance Test
;
Humans
;
Male
;
Mass Screening
;
Plasma
;
Prevalence
;
Sensitivity and Specificity
7.Regulation of DREAM Expression by Group I mGluR.
Jinu LEE ; Insook KIM ; So Ra OH ; Suk Jin KO ; Mi Kyung LIM ; Dong Goo KIM ; Chul Hoon KIM
The Korean Journal of Physiology and Pharmacology 2011;15(2):95-100
DREAM (downstream regulatory element antagonistic modulator) is a calcium-binding protein that regulates dynorphin expression, promotes potassium channel surface expression, and enhances presenilin processing in an expression level-dependent manner. However, no molecular mechanism has yet explained how protein levels of DREAM are regulated. Here we identified group I mGluR (mGluR1/5) as a positive regulator of DREAM protein expression. Overexpression of mGluR1/5 increased the cellular level of DREAM. Up-regulation of DREAM resulted in increased DREAM protein in both the nucleus and cytoplasm, where the protein acts as a transcriptional repressor and a modulator of its interacting proteins, respectively. DHPG (3,5-dihydroxyphenylglycine), a group I mGluR agonist, also up-regulated DREAM expression in cortical neurons. These results suggest that group I mGluR is the first identified receptor that may regulate DREAM activity in neurons.
Calcium
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Cytoplasm
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Dynorphins
;
Methoxyhydroxyphenylglycol
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Neurons
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Potassium Channels
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Presenilins
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Proteins
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Receptors, Metabotropic Glutamate
;
Up-Regulation
8.Crystalline podocytopathy and tubulopathy without overt glomerular proteinuria in a patient with multiple myeloma.
Eun Jeong LEE ; Su Yeon LEE ; So Young PARK ; Yonjin KIM ; Jae Shin CHOI ; Mi Jeoung KIM ; Ji Hyeon PARK ; Jung Eun LEE ; Ghee Young KWON ; Yoon Goo KIM
Kidney Research and Clinical Practice 2016;35(4):259-262
Crystalline nephropathy is a rare yet well-known condition associated with multiple myeloma and other light chain–secreting disorders. Paraproteins that are resistant to proteolysis crystallize within proximal tubular cells and cause light-chain proximal tubulopathy, which presents clinically as Fanconi syndrome. Podocytes are rarely affected, and the crystalline inclusions within podocytes are typically precipitated, yielding significant glomerular proteinuria. Here we report a case of extensive crystalline inclusions primarily within podocytes and proximal tubules that presented only with Fanconi syndrome and renal insufficiency. Despite the presence of extensive crystalline inclusions in podocytes and diffuse foot process effacement, the patient had no clinical evidence suggestive of podocyte injury.
Crystallins*
;
Fanconi Syndrome
;
Foot
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Humans
;
Multiple Myeloma*
;
Paraproteins
;
Podocytes
;
Proteinuria*
;
Proteolysis
;
Renal Insufficiency
9.Optimal Waist Circumference Cutoff Values for Metabolic Syndrome Diagnostic Criteria in a Korean Rural Population.
Jang Hyun KOH ; Sang Baek KOH ; Mi Young LEE ; Pil Moon JUNG ; Bo Hwan KIM ; Jang Yel SHIN ; Young Goo SHIN ; So Yeon RYU ; Tae Yong LEE ; Jong Ku PARK ; Choon Hee CHUNG
Journal of Korean Medical Science 2010;25(5):734-737
The Korean Society for the Study of Obesity (KSSO) has defined the waist circumference cutoff value of central obesity as 90 cm for men and 85 cm for women. The purpose of this investigation was to determine the corresponding waist circumference values. A total of 3,508 persons in the Korean Rural Genomic Cohort Study were enrolled in this survey. Receiver operating characteristic (ROC) curve analysis was used to find appropriate waist circumference cutoff values in relation to insulin resistance determined by homeostasis model assessment for insulin resistance (HOMA-IR), body mass index (BMI), and components of metabolic syndrome. The optimal waist circumference cutoff values were 87 cm for men and 83 cm for women by ROC analysis to HOMA-IR and 86 cm for men and 83 cm for women by ROC analysis to value with more than two components of metaobolic syndrome. By using a BMI > or =25 kg/m2, 86 cm for men and 82 cm for women were optimal waist circumference cutoff values. In this study, we suggest that the most reasonable waist circumference cutoff values are 86-87 cm for men and 82-83 cm for women.
Cohort Studies
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Diagnosis, Computer-Assisted/*methods
;
Female
;
*Health Status Indicators
;
Humans
;
Korea/epidemiology
;
Male
;
Metabolic Syndrome X/*diagnosis/*epidemiology
;
Middle Aged
;
Physical Examination/methods/statistics & numerical data
;
Prevalence
;
Reproducibility of Results
;
Risk Assessment/methods
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Risk Factors
;
Rural Population/*statistics & numerical data
;
Sensitivity and Specificity
;
*Waist Circumference
10.The Present Situation of Infection Control Professionals, Organization, and Activities in Korean Acute Care General Hospitals.
Jae Sim JEONG ; Sung Won YOON ; Eun Suk PARK ; Kyung Mi KIM ; So Yeon YOO ; Ihnsook JEONG ; Yong Ae SHIN ; Sun Ju CHOI ; Seung Ju KIM ; Hyang Soon OH ; Bong Su KIM ; Yeong Seon LEE ; Sook Ja YANG ; Sang Ill KIM ; Young Goo SONG ; Yang Soo KIM ; Moon Won KANG
Korean Journal of Nosocomial Infection Control 2006;11(1):58-69
BACKGROUND: It has been more than 15 years since infection control was first introduced in Korea, but there is little information available on the status of infection control program in the country. METHODS: Included in the study were 139 acute care hospitals with more than 300 inpatient beds. A questionnaire, modified from US SENIC (Study on the Efficacy of Nosocomial Infection Control) and Canadian RICH (Resources for Infection Control in Canadian Acute Care Hospitals) survey, was mailed to the hospitals in the winter of 2003. RESULTS: Ninety-eight (70.5%) of 139 hospitals responded. There was an average of 1.2 (SD, 0.7) Infection Control Practitioners (lCPs) in each hospital and 95.7% were nurses and only 56.5% of the ICPs worked as full-time. The 71.4% of the hospitals had a position for Infection Control Doctor. All hospitals had an Infection Control Committee, which met an average of 3.7 (SD, 1.7) times a year. The 85.7% of the hospitals performed surveillance, but only 31.6% were monitoring surgical site infections. Review of microbiology data was the most common method for case-finding. More than 90% of the hospitals had infection control policies and guidelines, but an adherence to the policies and guidelines was not monitored regularly. CONCLUSION: This study reports the first comparable profile of infection control program of general acute care hospitals in Korea. Although the foundation for infection control program appears to have been established, there is the need for a further increase in the number of ICPs, the standardization of the surveillance method, and the promotion of adherence to the infection control guidelines.
Cross Infection
;
Hospitals, General*
;
Humans
;
Infection Control Practitioners
;
Infection Control*
;
Inpatients
;
Korea
;
Postal Service
;
Surveys and Questionnaires