No abstract available.
Muscle, Smooth* ; Smooth Muscle Tumor*

No abstract available.
Gastrointestinal Tract* ; Muscle, Smooth* ; Smooth Muscle Tumor*

No abstract available.
Muscle, Smooth* ; Smooth Muscle Tumor* ; Stomach*

Glomus tumors are benign neoplasms that are derived from modified smooth muscle cells known as glomus cells. Histologically, it can be subdivided as glomus tumor proper, glomangioma, and glomangiomyoma according to relative proportions of components. Glomangiomyomas are the least frequent type and their overall architectural pattern may resemble glomus tumor proper or glomangioma, but there is a gradual transition from glomus cells to elongated mature smooth muscle cells. This transition is most obvious in the region surrounding large vessels. We present a case of glomangiomyoma of the left upper arm and the left fourth finger, in which ten-year history of two painful, bluish-colored subcutaneous nodules. On histologic examination, this case showed marked smooth muscle cell proliferation around large vessles and mucinous stromal change.
Arm ; Fingers ; Glomus Tumor ; Mucins* ; Muscle, Smooth* ; Myocytes, Smooth Muscle*

No abstract available.
Lower Gastrointestinal Tract* ; Muscle, Smooth* ; Smooth Muscle Tumor*

Cutaneous piloleiomyomas are benign smooth muscle tumors arising from the arrector pili muscles. Piloleiomyomas appear as firm dermal papules of skin color or with a reddish to brown surface, and are commonly located on the extremities. Histologically, these lesions are composed of interlacing bundles of smooth muscle cells in the reticular dermis. Our case presented with an unusually large nodule on the forehead that was accompanied by intermittent pain. Histological analysis was compatible with piloleiomyoma and the lesion showed haphazardly arranged bundles of smooth muscle in the dermis. We describe herein an interesting case of a giant piloleiomyoma occurring on the forehead.
Dermis ; Extremities ; Forehead ; Muscle, Smooth ; Muscles ; Myocytes, Smooth Muscle ; Skin ; Smooth Muscle Tumor

BACKGROUND: Controversy still remains concerning the criteria for the categorization of uterine smooth muscle tumors by conventional histologic examination. Various ancillary techniques have been used to improve diagnostic accuracy. METHODS: Immunohistochemical study of MIB-1 and p53 was performed on 10 usual leiomyomas (UL), 13 cellular leiomyomas (CL), 5 bizarre leiomyomas (BL), 2 cases of intravenous leiomyomatosis (IL), 5 smooth muscle tumors of uncertain malignant potential (STUMP) and 8 leiomyosarcomas (LMS), to investigate the diagnostic value of MIB-1 and p53 in uterine smooth muscle tumors. RESULTS: The MIB-1 labelling index was low in ULs and their variants (mean 5.67+/-5.53), but it was increased in STUMPs (17.67+/-6.51) and markedly increased in LMSs (35.71+/-11.35). In ULs and their variants, no immunostaining for p53 was noted except in one case of BL, while 2 (40%) of 5 STUMPs and 3 (38%) of 8 LMSs showed positive reactions for p53. There were significant differences among leiomyoma, STUMP and LMS in the MIB-1 labelling index and p53 expression. CONCLUSIONS:These results suggest that both abnormal expressions of p53 and a high MIB-1 labelling index are frequently associated with leiomyosarcoma. Our data also indicate that the classification system of Kempson and Hendrickson is well correlated with the MIB-1 labelling index.
Classification ; Immunohistochemistry ; Ki-67 Antigen ; Leiomyoma ; Leiomyomatosis ; Leiomyosarcoma ; Muscle, Smooth* ; Smooth Muscle Tumor* ; Uterine Neoplasms

Smooth muscle tumors are very common tumors in the uterus and related adjacent structures but occur rarely in the retroperitoneum. Traditionally, most retroperitoneal smooth muscle tumor are believed to be malignant. But well-differentiated smooth muscle tumors with lack of atypia, necrosis, and significant mitotic activity appear to have a benign behaviors. Laparotomy revealed a huge solid tumor in the retroperitoneal space, about 50 cm in diameter, and histologically diagnosed as a smooth muscle tumor of uncertain malignant potential (STUMP). We report a case of primary retroperitoneal smooth muscle tumor with a brief review of literatures.
Laparotomy ; Muscle, Smooth* ; Necrosis ; Ovarian Neoplasms* ; Retroperitoneal Space ; Smooth Muscle Tumor* ; Uterus

Smooth muscle tumors have been classified into leiomyoma and leiomyosarcoma. But the criteria for malignancy are not well defined. Traditionally, mitoses are the most important differentiating feature between leiomyoma and leiomyosarcoma. However mitotic activity was regarded as an acceptable finding in about 20% of cutaneous leiomyoma. The widely used designation "smooth muscle tumor of uncertain malignant potential" is a reflection of the limitation of available criteria to precisely diagnose tumors with borderline atypical features. We present herein a case of a cutaneous smooth muscle tumor of uncertain malignant potential, which is mitotically active, on the abdomen of a 45-year-old man.
Abdomen ; Humans ; Leiomyoma ; Leiomyosarcoma ; Middle Aged ; Mitosis ; Muscle, Smooth ; Muscles ; Smooth Muscle Tumor

BACKGROUND: Glomus tumor is a benign lesion composed of vessels and glomocytes in varying proportions. Although the histologic features of glomus tumors by light microscopy are characteristic and well recognized, there is controversy as to the histogenesis and cytological characterization of the glomus cell. OBJECTIVE: The aim of the present study was to verify the histopathological origin of a glornus tumor. Method: We investigated 1 cases of glomus tumors for immunohistochemical features. RESULTS: The glomus turnor cells were negative when stained for FactorVIII-related antigen and S-100 protein. Conversely, all materials were found to be positive for actin, vimentin, NSE. Sorne exhibited an equivocal reaction for desmin and CD34, the rest were negative. CONCLUSION: These findings support the hypothesis that the glomus cell is transitional-between smooth muscle and vascular ndothelium-being essentially a modified smooth muscle cell with some endothelial cell properties.
Actins ; Desmin ; Endothelial Cells ; Glomus Tumor* ; Microscopy ; Muscle, Smooth ; Myocytes, Smooth Muscle ; S100 Proteins ; Vimentin