1.Transformation into large-cell neuroendocrine carcinoma associated with acquired resistance to erlotinib in nonsmall cell lung cancer.
Jeong Uk LIM ; In Sook WOO ; Yun Hwa JUNG ; Jae Ho BYEON ; Chan Kwon PARK ; Tae Jung KIM ; Hyo Rim KIM
The Korean Journal of Internal Medicine 2014;29(6):830-833
No abstract available.
Adenocarcinoma/chemistry/*drug therapy/secondary
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Adult
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Antineoplastic Agents/*therapeutic use
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Biopsy
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Carcinoma, Large Cell/chemistry/*pathology
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Carcinoma, Neuroendocrine/chemistry/*pathology
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Carcinoma, Non-Small-Cell Lung/chemistry/*drug therapy/secondary
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*Drug Resistance, Neoplasm
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Humans
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Lung Neoplasms/chemistry/*drug therapy/pathology
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Magnetic Resonance Imaging
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Male
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Protein Kinase Inhibitors/*therapeutic use
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Quinazolines/*therapeutic use
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Tomography, X-Ray Computed
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Treatment Outcome
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Tumor Markers, Biological/analysis
2.Primary Small Cell Carcinoma of the Lung Presenting with Breast and Skin Metastases.
Fatih ALTINTOPRAK ; Halil Firat BAYTEKIN ; Canatan TASDEMIR
The Korean Journal of Internal Medicine 2011;26(2):207-209
Cutaneous metastases originating from an internal cancer are relatively uncommon in clinical practice, and metastatic lesions to the breast are rarer than those to the skin. Skin metastases of lung cancer, which may be the first sign of the disease, usually indicate progressive disease and a poor prognosis. We describe a 47-year-old male who presented with recurring masses in the lumbar region bilaterally and the right breast. Immunohistochemical findings and radiological imaging suggested lung cancer. This is the first reported case of small cell lung cancer metastasizing to two separate, uncommon sites, the skin and breast.
Biopsy
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Breast Neoplasms, Male/chemistry/*secondary/therapy
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Fatal Outcome
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Humans
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Immunohistochemistry
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Lung Neoplasms/chemistry/*pathology/therapy
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Male
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Middle Aged
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Skin Neoplasms/chemistry/*secondary/therapy
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Small Cell Lung Carcinoma/chemistry/*secondary/therapy
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Tomography, X-Ray Computed
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Treatment Outcome
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Tumor Markers, Biological/analysis