PURPOSE: To present a rare case of Muir-Torre syndrome characterized by the association of sebaceous skin tumors and systemic malignancies. CASE SUMMARY: A 65-year-old female visited our clinic with an irregular nodular mass of the right lower eyelid, which developed 1 year earlier. An excisional biopsy and lower lid reconstruction with Tenzel's semicircular rotational flap was performed under local anesthesia. Histopathologic examination showed well-differentiated sebaceous cells, consistent with sebaceous adenoma. The patient had undergone total abdominal hysterectomy and lower anterior resection due to endometrial cancer and sigmoid colon cancer 5 years before, and nephroureterectomy due to papillary urothelial carcinoma 3 years before. Based on the history of systemic malignancy and sebaceous skin cancer, a diagnosis of Muir-Torre syndrome was made. CONCLUSIONS: When a sebaceous gland tumor of the eyelids is detected, Muir-Torre syndrome should be included in the differential diagnosis, and systemic work-up for the internal malignancy must be performed.
Adenoma ; Aged ; Anesthesia, Local ; Biopsy ; Diagnosis, Differential ; Endometrial Neoplasms ; Eyelids ; Female ; Humans ; Hysterectomy ; Muir-Torre Syndrome ; Sebaceous Glands ; Sigmoid Neoplasms ; Skin ; Skin Neoplasms

Muir-Torre syndrome is defined by concurrent or sequential development of internal malignancy and sebaceous neoplasm or multiple keratoacanthomas. Muir-Torre syndrome is very rare, with only 205 cases reported in the literature. We reported a patient with Muir-Torre syndrome with three internal malignancies. A 64-year-old patient with a history of breast cancer, stomach cancer and colon cancer visited our department for treatment of the skin lesion that occurred five years before on the left cheek. The lesion was excised completely with a resection margin of 1 cm, followed by full-thickness skin graft from left postauricular area for reconstruction. Histopathology revealed a 0.2 x 0.2 x 0.1 cm sized sebaceous carcinoma with 4 mm safety margin. The skin graft was well taken within 7 days after surgery and the patient was discharged to outpatient follow-up. There was no complication related with surgery. Muir-Torre syndrome is very rare, as are sebaceous gland tumors. So if a cancer of the sebaceous gland is diagnosed, screening workup for internal malignancy is recommended. Because of its good prognosis, surgical removal of primary or metastatic cancers may be curative and should be attempted where possible.
Breast ; Breast Neoplasms ; Cheek ; Colon ; Colonic Neoplasms ; Follow-Up Studies ; Humans ; Keratoacanthoma ; Mass Screening ; Muir-Torre Syndrome ; Outpatients ; Prognosis ; Sebaceous Glands ; Skin ; Stomach ; Stomach Neoplasms ; Transplants

Sebaceous carcinoma is a very rare and potentially aggressive carcinoma originating from the epithelial lining of the sebaceous gland. More than 70% of all cases are in the head and neck region, especially the periorbita; therefore, they are classified into ocular and extraocular sebaceous carcinoma. The reported risk factors are advanced age, male sex, previous irradiation, and genetic predisposition for Muir-Torre syndrome. The current case is of sebaceous carcinoma found in the suprapubic area of a 67-year-old male patient who had received liver transplantation 6 years before, and had been receiving oral tacrolimus. Examination of the gastrointestinal system did not reveal any other malignancies. Although nonmelanoma skin cancers may occur as a complication after liver transplantation, there have been no previous reports of sebaceous carcinoma after liver transplantation. Furthermore, the sebaceous carcinoma in this case occurred in an uncommon location. We report this case along with a review of the literature.
Aged ; Genetic Predisposition to Disease ; Head ; Humans ; Liver Transplantation ; Liver* ; Male ; Muir-Torre Syndrome ; Neck ; Risk Factors ; Sebaceous Glands ; Skin Neoplasms ; Tacrolimus ; Transplantation*

Adenoma, Sweat Gland ; metabolism ; Diagnosis, Differential ; Humans ; Keratin-14 ; metabolism ; Keratin-17 ; metabolism ; Keratin-18 ; metabolism ; Keratin-7 ; metabolism ; Keratins ; metabolism ; Papilloma ; metabolism ; Sebaceous Gland Neoplasms ; metabolism ; Skin Neoplasms ; metabolism ; Sweat Gland Neoplasms ; metabolism

No abstract available.
Muir-Torre Syndrome*

Superficial epithelioma with sebaceous differentiation (SESD) is a rare benign neoplasm with peculiar histopathologic characteristics, which occurs in aged skin. We report upon a case of SESD occurring on the left upper back, which histopathologically is a superficial, multilobular tumor with numerous basaloid cells mixed with sebaceous cells attached to the overlying epidermis. This case represents a solitary benign neoplasm without any associated malignancy.
Carcinoma, Basal Cell/*pathology ; Female ; Human ; Middle Aged ; Sebaceous Gland Neoplasms/pathology ; Sebaceous Glands/*pathology ; Skin Neoplasms/*pathology

Acanthoma ; pathology ; Humans ; Keratosis ; pathology ; Skin Neoplasms ; pathology

Pilar sheath acanthoma is a rare, benign follicular hamartoma that commonly affects middle aged and elderly patients. Clinically, solitary, asymptomatic, skin-colored nodules with a central pore-like opening are seen for more than one year. As a consequence of the histology, pilar sheath acanthoma should be differentiated from trichofolliculoma and dilated pore of Winer. We report here on a case of pilar sheath acanthomas that presented as asymptomatic solitary skin colored nodules on both cheeks.
Acanthoma ; Aged ; Cheek ; Follicular Cyst ; Hamartoma ; Humans ; Middle Aged ; Neoplasms, Basal Cell ; Skin ; Skin Neoplasms

Pilar sheath acanthoma is a rare, benign follicular hamartoma commonly affecting middle-aged and elderly individuals. It is characterized by a small, solitary, skin-colored papule situated on the head and neck, particularly around the upper lip. The lesion shares some features with trichofolliculoma and dilated pore of Winer, so it should be differentiated from these. Cytokeratin (CK) is a useful marker for studying the origin of epithelial tumors. We report a case of pilar sheath acanthoma which originated from outer root sheath using CK.
Acanthoma ; Aged ; Follicular Cyst ; Hamartoma ; Head ; Humans ; Keratins ; Lip ; Neck ; Neoplasms, Basal Cell ; Skin Neoplasms

No abstract available.
Skin Neoplasms* ; Skin*