Aged ; Breast Neoplasms ; complications ; Female ; Humans ; Skin Neoplasms ; diagnosis ; etiology

Humans ; Aluminum/adverse effects* ; Pruritus/etiology* ; Skin Neoplasms ; Vaccination ; Hypersensitivity

Electron microscopy on the skin of young frogs, Rana temporaria, has been carried out with particular reference to cellular attachment sites. For the first time now several technical developments allow a more detailed visualization of the fine structure within the cellular attachment sites as well as making it possible to show the ultrastructural morphology of the junctional complexes, and to demonstrate that the desmosomes are regularly distributed around each skin cell, especially in the S. granulosum. The relations of these findings to those of previous investigations concerning the functional organization of the junctional complexes and to the findings in skin cancer from a cellular adhesion view point have been briefly discussed.
Animal ; Anura ; Cell Membrane ; Epithelial Cells* ; Microscopy, Electron ; Skin/cytology* ; Skin Neoplasms/etiology

Highly transient population, multiple sexual partners and high prevalence of unprotected sex behaviors suggest a potential rapid spread of sexually transmitted diseases (STD) in China. However, there are some 200 non-sexually transmitted diseases involving the genitalia, etiologically falling into 23 types. To avoid unnecessary medical disputes, enough attention should be paid to the differential diagnosis of non-sexually transmitted diseases in the genitalia.
Female ; Genital Diseases, Female ; diagnosis ; etiology ; Genital Diseases, Male ; diagnosis ; etiology ; Genital Neoplasms, Male ; diagnosis ; Humans ; Male ; Skin Diseases, Infectious ; diagnosis ; etiology ; Skin Neoplasms ; diagnosis

We herein present the case of a 55-year-old woman with a previous history of malignancies--uterine adenocarcinoma, basal cell carcinoma (which occurred twice consecutively), recurrent respiratory infections due to common variable immunodeficiency (CVID), and systemic granulomatous disease diagnosed at a later age. The patient suffered from diffuse large B cell lymphoma (DLBCL), which was successfully treated with R-CHOP chemotherapy, and continued with immunoglobulin supplementation. The patient was free of lymphoma and infectious complications for over 20 months despite her persistent immunodeficiency, but eventually developed colorectal adenocarcinoma. To the best of our knowledge, this is the first reported case of CVID associated with multiple solid tumours and DLBCL.
Adenocarcinoma ; etiology ; Carcinoma, Basal Cell ; etiology ; Common Variable Immunodeficiency ; complications ; diagnosis ; therapy ; Fatal Outcome ; Female ; Humans ; Lymphoma, Large B-Cell, Diffuse ; etiology ; Middle Aged ; Neoplasms, Multiple Primary ; etiology ; pathology ; therapy ; Respiratory Tract Infections ; etiology ; Skin Neoplasms ; etiology ; Uterine Neoplasms ; etiology

Capsule Endoscopy ; Child, Preschool ; Female ; Gastrointestinal Neoplasms ; etiology ; pathology ; Humans ; Lymphangioma, Cystic ; etiology ; pathology ; Nevus, Blue ; etiology ; pathology ; Skin Neoplasms ; etiology ; pathology

A 63-year-old female was admitted to our hospital with a tender abdominal wall mass about 15 cm in diameter, which she had for 1 month. About 1 week earlier, the patient had also perceived a mass in the neck area. Computed tomography revealed huge thyroid and periumbilical masses. The thyroid hormone levels were consistent with a hyperthyroid state. Pathological examination of the thyroid mass was compatible with anaplastic thyroid carcinoma (ATC) and the abdominal cutaneous mass was shown to be metastatic ATC. Despite palliative radiotherapy and chemotherapy, the patient died of respiratory failure on her 63rd day of hospitalization. This case demonstrates that abdominal cutaneous metastasis and hyperthyroidism can occur as initial manifestations of ATC. To our knowledge, this is the first reported case.
Abdomen ; Female ; Humans ; Hyperthyroidism/*etiology ; Middle Aged ; Skin Neoplasms/*secondary ; Thyroid Neoplasms/pathology

Aged ; Carcinoma, Squamous Cell ; diagnosis ; etiology ; Facial Neoplasms ; diagnosis ; Female ; Humans ; Skin Neoplasms ; diagnosis ; etiology ; Skin Ulcer ; complications ; diagnosis ; Tooth Extraction

BACKGROUNDOur previous studies revealed cyclicity in the incidence rate of skin malignant melanoma (SMM; ICD9, Dx:172) in the Czech Republic (period T=7.50-7.63 years), UK (T=11.00 years) and Bulgaria (T=12.20 years). Incidences compared with the sunspot index Rz (lag-period dT=+2, +4, +6, +10 or +12 years) have indicated that maximal rates are most likely to appear on descending slopes of the 11-year solar cycle, i.e., out of phase. We summarized and explored more deeply these cyclic variations and discussed their possible associations with heliogeophysical activity (HGA) components exhibiting similar cyclicity.

METHODSAnnual incidences of SMM from 5 countries (Czech Republic, UK, Bulgaria, USA and Canada) over various time spans during the years 1964-1992 were analyzed and their correlations with cyclic Rz (sunspot number) and aa (planetary geomagnetic activity) indices were summarized. Periodogram regression analysis with trigonometric approximation and phase-correlation analysis were applied.

RESULTSPrevious findings on SMM for the Czech Republic, UK and Bulgaria have been validated, and cyclic patterns have been revealed for USA (T=8.63 years, P<0.05) and Canada (Ontario, T=9.91 years, P<0.10). Also, various 'hypercycles' were established (T=45.5, 42.0, 48.25, 34.5 and 26.5 years, respectively) describing long-term cyclic incidence patterns. The association of SMM for USA and Canada with Rz (dT=+6 and +7 years, respectively) and aa (dT=-10 and +9 years, respectively) was described. Possible interactions of cyclic non-photic influences (UV irradiation, Schumann resonance signal, low-frequency geomagnetic fluctuations) with brain waves absorbance, neuronal calcium dynamics, neuro-endocrine axis modulation, melatonin/serotonin disbalance and skin neuro-immunity impairment as likely causal pathways in melanoma appearance, were also discussed.

CONCLUSIONThe above findings on cyclicity and temporal association of SMM with cyclic environmental factors could not only allow for better forecasting models but also lead to a better understanding of melanoma aetiology.

Cosmic Radiation ; adverse effects ; Female ; Forecasting ; Humans ; Male ; Melanoma ; epidemiology ; etiology ; Models, Biological ; Neoplasms, Radiation-Induced ; epidemiology ; etiology ; Periodicity ; Regression Analysis ; Skin Neoplasms ; epidemiology ; etiology ; Solar Activity

Diagnosis, Differential ; Eyelid Neoplasms ; diagnosis ; etiology ; Female ; Humans ; Lymphoma, B-Cell, Marginal Zone ; diagnosis ; etiology ; Middle Aged ; Sarcoidosis ; complications ; diagnosis ; Skin Neoplasms ; diagnosis ; etiology