1.Trichilemmal Carcinoma of the Upper Eyelid: A Case Report.
Ju Hyang LEE ; Yong Woon SHIN ; Young Ha OH ; Yoon Jung LEE
Korean Journal of Ophthalmology 2009;23(4):301-305
We report a very rare case of trichilemmal carcinoma (TLC) involving the upper eyelid. To the best of our knowledge, this is the first report of trichilemmal carcinoma of the upper eyelid in Korea. A 51-year-old man presented to our hospital complaining of a bloody discharge from his left upper eyelid. He had a soft and lobulated mass on the palpebral conjunctiva. An incisional biopsy revealed trabecular growth of tumor cells with clear cytoplasm, prominent nucleoli, frequent mitoses, and foci of trichilemmal keratinization. Immunohistochemically, the lesion was positive for p53 and negative for CD 34. A diagnosis of TLC was made, and total excision of the mass and reconstruction of the eyelid were performed. Trichilemmal carcinoma is a rare malignant tumor, though it appears to be an indolent neoplasm with no metastatic potential. The treatment of choice for trichilemmal carcinoma of the eyelid is complete excision with tumor-free margins due to the locally invasive nature of the lesion.
Carcinoma, Skin Appendage/*pathology/surgery
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Diagnosis, Differential
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Eyelid Neoplasms/*pathology/surgery
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Follow-Up Studies
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*Hair
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Humans
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Male
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Middle Aged
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Mohs Surgery
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Skin Neoplasms/*pathology/surgery
2.Meningeal melanocytoma with nevus fuscoceruleus ophthalmomaxillaris: report of a case.
Chun WU ; Hai WANG ; Qun-li SHI ; Heng-hui MA ; Zhen-feng LU
Chinese Journal of Pathology 2011;40(3):194-195
Adult
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Diagnosis, Differential
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Humans
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MART-1 Antigen
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metabolism
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Magnetic Resonance Imaging
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Male
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Medulloblastoma
;
metabolism
;
pathology
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Melanocytes
;
pathology
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Melanoma
;
diagnosis
;
metabolism
;
pathology
;
surgery
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Melanoma-Specific Antigens
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metabolism
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Meningeal Neoplasms
;
diagnosis
;
metabolism
;
pathology
;
surgery
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Neoplasms, Multiple Primary
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diagnosis
;
metabolism
;
pathology
;
surgery
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Neurilemmoma
;
metabolism
;
pathology
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Nevus of Ota
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diagnosis
;
metabolism
;
pathology
;
surgery
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S100 Proteins
;
metabolism
;
Skin Neoplasms
;
diagnosis
;
metabolism
;
pathology
;
surgery
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Vimentin
;
metabolism
3.A Case of Microcystic Adnexal Carcinoma with Secondary Cicatricial Alopecia.
Ho Jeong SHIN ; Young Jae KIM ; Chong Hyun WON ; Sung Eun CHANG ; Mi Woo LEE ; Jee Ho CHOI ; Woo Jin LEE
Korean Journal of Dermatology 2018;56(7):447-451
Microcystic adnexal carcinoma (MAC) was first described in 1982 by Goldstein. Considered a rare malignant skin appendageal tumor, it is often underdiagnosed due to its clinical and histopathological resemblance to other cutaneous neoplasms. MAC is locally aggressive with infiltration of perineural spaces, subcutaneous tissue, skeletal muscles, and so on. Aggressive treatment including wide local excision, Mohs micrographic surgery, or radiation therapy is necessary owing to the high recurrence rate. Herein, we report a case of a 47-year-old Korean woman with a skin-colored hardened plaque on the scalp with a clinical diagnosis of cicatricial alopecia and histopathological diagnosis of MAC. After treatment by Mohs micrographic surgery, the patient is being followed up regularly without any sign of recurrence. This case demonstrates an uncommon topography of MAC on the scalp with secondary cicatricial alopecia and highlights the need for awareness of the potential for MAC in the diagnosis of alopecia with a slow-growing tumor.
Alopecia*
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Diagnosis
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Female
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Humans
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Middle Aged
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Mohs Surgery
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Muscle, Skeletal
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Pathology
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Recurrence
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Scalp
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Skin
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Skin Neoplasms
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Subcutaneous Tissue
4.Microcystic adnexal carcinoma: report of two cases.
Wei FANG ; Dong CHEN ; Jian-feng SHANG ; Fu WANG ; Lei XIAO
Chinese Journal of Pathology 2009;38(1):59-60
Adult
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Arm
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Carcinoembryonic Antigen
;
metabolism
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Carcinoma, Basal Cell
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pathology
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Carcinoma, Skin Appendage
;
metabolism
;
pathology
;
surgery
;
Diagnosis, Differential
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Head and Neck Neoplasms
;
metabolism
;
pathology
;
surgery
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Humans
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Male
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Middle Aged
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Mucin-1
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metabolism
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Skin Neoplasms
;
metabolism
;
pathology
;
surgery
5.Primary mucinous carcinoma of skin: report of a case.
Si-chun WU ; Shan-ping LIN ; Xin-mei XIE
Chinese Journal of Pathology 2011;40(3):196-197
Adenocarcinoma, Mucinous
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metabolism
;
pathology
;
surgery
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Aged
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Diagnosis, Differential
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Facial Neoplasms
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metabolism
;
pathology
;
surgery
;
Gastrointestinal Neoplasms
;
metabolism
;
pathology
;
Humans
;
Keratin-19
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metabolism
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Keratin-20
;
metabolism
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Keratin-7
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metabolism
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Male
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Receptors, Estrogen
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metabolism
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Skin Neoplasms
;
metabolism
;
pathology
;
surgery
6.Malignant melanoma of the back metastatic to thyroid gland: report of a case.
Cheng-lin FU ; Xian-tu ZHANG ; Jin-na ZHANG
Chinese Journal of Pathology 2011;40(2):121-122
Aged
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Back
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Carcinoma, Medullary
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metabolism
;
pathology
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Diagnosis, Differential
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Female
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Humans
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Melanoma
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metabolism
;
pathology
;
secondary
;
surgery
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Melanoma-Specific Antigens
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metabolism
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S100 Proteins
;
metabolism
;
Skin Neoplasms
;
metabolism
;
pathology
;
surgery
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Thyroid Neoplasms
;
metabolism
;
pathology
;
secondary
;
surgery
7.Inclusion body fibromatosis: report of a case.
Rong-jun MAO ; Hui-qiong FANG ; Bin HE ; Qi-ming LI
Chinese Journal of Pathology 2012;41(1):52-53
Calcium-Binding Proteins
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metabolism
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Diagnosis, Differential
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Female
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Fibroma
;
metabolism
;
pathology
;
surgery
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Humans
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Inclusion Bodies
;
pathology
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Infant
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Microfilament Proteins
;
metabolism
;
Skin Neoplasms
;
metabolism
;
pathology
;
surgery
;
Soft Tissue Neoplasms
;
pathology
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Tendons
;
pathology
;
Toes
;
Vimentin
;
metabolism
8.Treatment Outcomes of Advanced Stage Malignant Melanoma in Hand and Foot after Amputation in Korean Patients.
Clinics in Orthopedic Surgery 2013;5(4):314-320
BACKGROUND: A retrospective study was conducted to review the overall survival and treatment outcomes of high grade melanoma in the extremity to explore the clinical features of malignant melanoma of the hand and foot, and the therapeutic efficacies and survival rate after amputation. METHODS: The clinical data of 30 patients with malignant melanoma of the hand and foot (confirmed by pathological examination), who were admitted and treated in our hospital between 2001 and 2010, were analyzed retrospectively. We analyzed variables affecting overall and disease-free survival. RESULTS: Thirty patients (18 men and 12 women) treated with an amputation procedure for malignant melanoma in the hand or foot constituted the study cohort. The average age of the patients at the time of diagnosis was 58.7 years. Univariate analysis for overall melanoma survival revealed that diagnosis at over 70 years of age, postoperative lymph node metastasis, and location of the tumor were significant prognostic factors. And on the Kaplan-Meier survival curve, old age, American Joint Committee on Cancer stage and postoperative lymph node metastasis showed statistically significant differences in the 5-year survival rate. Also, amputation with aggressive lymph node dissection showed improved long term survival in advanced stage melanoma. CONCLUSIONS: In Korean melanoma patients, for the treatment of high grade melanomas in the extremities after amputation, early diagnosis and postoperative follow-up for evaluation of lymph node metastasis are critical factors for long-term survival. And by performing lymph node dissection during amputation, we may improve the survival rate in advanced stage melanoma patients.
Aged
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*Amputation
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Analysis of Variance
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Disease-Free Survival
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Female
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Foot/*surgery
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Hand/*surgery
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Humans
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Kaplan-Meier Estimate
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Male
;
Melanoma/diagnosis/pathology/*surgery
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Middle Aged
;
Neoplasm Staging
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Prognosis
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Republic of Korea
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Retrospective Studies
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Skin Neoplasms/diagnosis/pathology/*surgery
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Survival Rate
;
Treatment Outcome
9.Early Gastric Cancer with Cellulitis-like Skin Metastasis.
Yong Ho JANG ; Do Hyoung LIM ; Yo Han KIM ; Won Yong SUH ; Keon Woo PARK ; Il Han SONG ; Soon Il LEE
The Korean Journal of Gastroenterology 2014;63(1):39-41
Skin metastasis from internal carcinoma rarely occurs and it has an incidence of 0.7% to 9%. Although the prognosis of the skin metastases varies considerably depending on the type of the primary malignancy, presence of metastatic skin cancer usually implies a widespread systemic disease and a high mortality. A 50-year-old Korean male patient visited Dankook University Hospital for evaluation of skin rash on his whole abdomen of about 1 month's duration. He had undergone laparoscopy-assisted distal gastrectomy due to early gastric cancer about 3 months ago. He did not complain of any noticeable symptoms like febrile sense or pruritus. Skin biopsy was performed on the periumbilical area at previous port site and around the scar. Microscopic examination revealed multiple malignant cells in lymphatic spaces, consistent with metastatic carcinoma. He was therefore diagnosed with isolated skin metastasis from early gastic cancer. Because of patient's poor liver function, systemic chemotherapy could not be performed and only best supportive care was provided. Herein, we report a rare case of cellulitis-like skin metastasis from early gastric cancer with a brief review of the literature.
Carcinoma/*diagnosis/pathology/surgery
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Exanthema
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Humans
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Keratin-7/metabolism
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Laparoscopy
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Lymphatic Metastasis
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Male
;
Middle Aged
;
Neoplasm Staging
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Positron-Emission Tomography
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Skin Neoplasms/metabolism/pathology/secondary
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Stomach Neoplasms/*diagnosis/pathology/surgery
;
Tomography, X-Ray Computed
10.Atrophic dermatofibrosarcoma protuberans: report of a case.
Xiao-yu HAN ; Hong-quan WEI ; Qing PAN ; Jun LIU
Chinese Journal of Pathology 2013;42(1):52-53
Adult
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Antigens, CD
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metabolism
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Antigens, CD34
;
metabolism
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Antigens, Differentiation, Myelomonocytic
;
metabolism
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Dermatofibrosarcoma
;
metabolism
;
pathology
;
surgery
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Diagnosis, Differential
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Female
;
Fibroma
;
metabolism
;
pathology
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Humans
;
Lipoma
;
pathology
;
Neurofibroma
;
metabolism
;
pathology
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Receptors, Cell Surface
;
metabolism
;
Skin Neoplasms
;
metabolism
;
pathology
;
surgery