1.Reactive dye induced occupational asthma without nonspecific bronchial hyperreactivity.
Hae Sim PARK ; Mi Kyung LEE ; Chein Soo HONG
Yonsei Medical Journal 1990;31(2):98-102
Current asthma is often excluded by the presence of normal bronchial hyperresponsiveness. We report two asthmatic patients with normal bronchial hyperresponsiveness and one asthmatic patient with mild bronchial hyperresponsiveness (methacholine PC20; 24 mg/ml) which was presumed to be caused by sensitization and exposure to Black GR, the most frequent sensitizer among reactive dyes. They all complained of lower respiratory symptoms after work as well as at the workstation. The bronchoprovocation test with Black GR revealed isolated immediate bronchoconstrictions in all 3 patients and all had high specific IgE antibodies to Black GR-human serum albumin conjugate. After one worker continued at work for 3 days, he experienced a marked drop of methacholine PC20, and it returned to the pre-exposure level during 1 week. The other patient whose initial methacholine challenge was negative developed bronchial hyperresponsiveness on the first day after the dye bronchoprovocation, and returned to normal bronchial hyperresponsiveness on the third day. These findings suggested that patients with occupational asthma caused by reactive dye may not always have bronchial hyperresponsiveness to methacholine, and the screening program utilizing methacholine challenges may not always identify these patients.
Adult
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Asthma/*chemically induced
;
Bronchial Provocation Tests/methods
;
Bronchoconstriction/*drug effects
;
Dyes/*adverse effects
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Human
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Hypersensitivity, Delayed
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Immunoglobulin E/analysis
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Male
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Occupational Diseases/*chemically induced
;
Skin Tests
2.A case of acute methotrexate toxicity.
Annals of the Academy of Medicine, Singapore 2011;40(2):97-99
Acute Disease
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Antimetabolites, Antineoplastic
;
adverse effects
;
toxicity
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Drug-Related Side Effects and Adverse Reactions
;
Female
;
Folic Acid Antagonists
;
therapeutic use
;
Humans
;
Methotrexate
;
adverse effects
;
toxicity
;
Middle Aged
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Nausea
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chemically induced
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Risk Factors
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Skin Diseases
;
chemically induced
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Vomiting
;
chemically induced
3.Cutaneous pseudolymphoma occurring after traumatic implantation of a foreign red pigment.
Wei Liang KOH ; Yong Kwang TAY ; Mark Jean Aan KOH ; Chee Seng SIM
Singapore medical journal 2013;54(5):e100-1
Cutaneous pseudolymphoma is an uncommon, benign lymphoproliferative disorder of the skin. Although this condition is most commonly idiopathic, its occurrence has been associated with cosmetic tattoos. We report a unique case of cutaneous pseudolymphoma that occured after accidental, traumatic inoculation of a red pigment in a healthy 33-year-old woman.
Adult
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Betamethasone
;
analogs & derivatives
;
therapeutic use
;
Biopsy
;
Coloring Agents
;
adverse effects
;
Female
;
Forehead
;
pathology
;
Humans
;
Lacerations
;
Lymphoproliferative Disorders
;
diagnosis
;
etiology
;
Pseudolymphoma
;
chemically induced
;
diagnosis
;
Skin
;
pathology
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Skin Diseases
;
chemically induced
;
diagnosis
;
Triamcinolone Acetonide
;
therapeutic use
4.Therapeutic efficacy and prognostic factors of sorafenib treatment in patients with unresectable primary hepatocellular carcinoma.
Lan ZHANG ; Zheng-gang REN ; Yu-hong GAN ; Yan-hong WANG ; Bo-heng ZHANG ; Yi CHEN ; Xiao-ying XIE ; Nin-ling GE ; Sheng-long YE
Chinese Journal of Oncology 2010;32(8):630-633
OBJECTIVETo evaluate the efficacy and analyze the prognostic factors of sorafenib treatment in patient with unresectable primary hepatocellular carcinoma (HCC).
METHODSDuring the period from December 2005 to March 2009, 50 patients with unresectable primary HCC of Child-Pugh status A were treated with sorafenib (400 mg, Bid). The tumor response was evaluated with CT or MRI imaging every 6 - 8 weeks according to the RECIST criteria. The overall survival (OS) and time to progression (TTP) were defined as the time from administration of sorafenib to the death or the last follow up and were evaluated by Kaplan-Meier method.
RESULTSThere was no PR or CR, but 28 patients (56.0%) achieved stable disease. The median follow up time was 15 months with a median OS of 14 months and median TTP of 4 months. The common adverse events were dermal reaction (68.0%, 34/50), diarrhea (52.0%, 26/50), hypertension (4.0%, 2/50), hair loss (14.0%, 7/50), myelosuppression (16.0%, 8/50), and liver dysfunction (20.0%, 10/50). However, most of the drug-related adverse events were grade I-II and reversible. The patients with lower tumor burden and without distant metastasis had better prognosis.
CONCLUSIONSoafenib is effective for unresectable primary HCC with tolerable toxicity. Tumor stage is a predominant prognostic factor.
Adult ; Aged ; Alopecia ; chemically induced ; Antineoplastic Agents ; adverse effects ; therapeutic use ; Benzenesulfonates ; adverse effects ; therapeutic use ; Carcinoma, Hepatocellular ; drug therapy ; Chemoembolization, Therapeutic ; methods ; Diarrhea ; chemically induced ; Disease Progression ; Follow-Up Studies ; Humans ; Hypertension ; chemically induced ; Liver Neoplasms ; drug therapy ; Male ; Middle Aged ; Neoplasm Staging ; Niacinamide ; analogs & derivatives ; Phenylurea Compounds ; Pyridines ; adverse effects ; therapeutic use ; Skin Diseases ; chemically induced ; Survival Rate
5.Significant changes of bronchial responsiveness to methacholine after early asthmatic reaction to toluene diisocyanate (TDI) in a TDI-sensitive asthmatic worker.
Hae Sim PARK ; Young Soo CHO ; Jae Nam PARK ; Jin Heum BAIK ; Nam Soo RHU ; Dong ill CHO ; Jae Won KIM
Journal of Korean Medical Science 1990;5(4):185-188
Current asthma is often diagnostically excluded by the presence of normal bronchial responsiveness. We report on a TDI-induced occupational asthma patient with normal bronchial responsiveness. He had suffered from shortness of breath during and after TDI exposure for several months. His initial methacholine bronchial challenge test showed a negative response. The bronchoprovacation test with TDI showed an isolated immediate bronchoconstriction. The following methacholine bronchial challenge tests revealed that the bronchial hyperresponsiveness developed seven hours after the TDI challenge (methacholine PC20:5.1 mg/ml), progressed up until 24 hours, and returned to normal on the seventh day. This case provides evidence that the response of the airway to TDI may not always be accompanied by bronchial hyperresponsiveness to methacholine. Screening programs utilizing methacholine challenges may not always identify TDI-sensitized asthmatic workers.
Adult
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Asthma/*chemically induced/diagnosis
;
Bronchial Provocation Tests
;
Bronchoconstriction/*drug effects
;
Humans
;
Male
;
Methacholine Chloride/*diagnostic use
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Occupational Diseases/*chemically induced
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Skin Tests
;
Time Factors
;
Toluene 2,4-Diisocyanate/*adverse effects
6.BTEX Exposure and its Health Effects in Pregnant Women Following the Hebei Spirit Oil Spill.
Byung Mi KIM ; Eun kyo PARK ; So Young LEEAN ; Mina HA ; Eun Jung KIM ; Hojang KWON ; Yun Chul HONG ; Woo Chul JEONG ; Jongil HUR ; Hae Kwan CHEONG ; Jongheop YI ; Jong Ho KIM ; Bo Eun LEE ; Ju Hee SEO ; Moon Hee CHANG ; Eun Hee HA
Journal of Preventive Medicine and Public Health 2009;42(2):96-103
OBJECTIVES: We evaluated the health effects of exposure to BTEX (Benzene, Toluene, Ethylbenzene, m,p-Xylene, o-Xylene) in the Taean area after the Hebei Spirit oil spill. METHODS: We used a questionnaire survey to look for health effects among 80 pregnant women 2 to 3 months following the Hebei Spirit oil spill. Their BTEX exposures were estimated using the CALPUFF method. We then used a multiple logistic regression analysis to evaluate the effects of BTEX exposure on the women's health effets. RESULTS: Pregnant women who lived near the accident site reported more symptoms of eye irritation and headache than those who lived farther from the site. There was a trend of decreasing symptoms with an increase in distance from the spill site. Pregnant women exposed to higher ambient cumulative levels of Xylene were significantly more likely to report symptoms of the skin (OR 8.01 95% CI=1.74-36.76) in the first day after the accident and significantly more likely to report abdominal pain (OR 3.86 95% CI=1.02-14.59 for Ethylbenzene, OR 6.70 95% CI=1.82-24.62 for Xylene) during the 1st through 4th days following the accident. CONCLUSIONS: This study suggests that exposure to BTEX from an oil spill is correlated with an increased risk of health effects among pregnant women. This implies the need to take proper measures, including the development of a national policy for environmental health emergencies and a plan for studying the short- and long-term chronic health effects associated with such spills.
Adult
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Benzene/*adverse effects/analysis
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Benzene Derivatives/*adverse effects/analysis
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*Disasters
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*Environmental Exposure
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Environmental Pollutants/*adverse effects/analysis
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Eye Diseases/chemically induced/epidemiology
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Female
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Health Surveys
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Humans
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*Petroleum
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Pregnancy
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Questionnaires
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Respiratory Tract Diseases/chemically induced/epidemiology
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Risk Factors
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Skin Diseases/chemically induced/epidemiology
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Time Factors
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Toluene/analysis
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*Women's Health
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Xylenes/analysis
9.Treatment of Epidermal Growth Factor Receptor Inhibitors Associated Adverse Skin Reactions by Zhiyang Pingfu Liquid: a Clinical Study.
Hong-yan WANG ; Chao ZOU ; Hui-juan CUI ; Yan-ping BAI ; Yuan LI ; Huang-ying TAN ; Wei WANG ; Hai JU
Chinese Journal of Integrated Traditional and Western Medicine 2015;35(7):820-822
OBJECTIVETo study the curative effect of Zhiyang Pingfu Liquid (ZPL) in treating epidermal growth factor receptor inhibitors (EGFRIs) associated adverse reactions of the skin.
METHODSAll 54 patients with pathologically confirmed malignant tumor had EGFRIs induced adverse reactions of the skin to various degrees. ZPL was externally applied for them all, once or twice per day, 14 days consisting of one therapeutic course. Changes of adverse skin reactions, time for symptoms relief, adverse skin reaction types suitable for ZPL were observed before and after treatment.
RESULTSEGFRIs associated skin adverse reactions were improved to various degrees after they used ZPL. The shortest symptoms relief time was 1 day while the longest was 12 days, with an average of 6.93 days and the median time 7 days. Compared with before treatment, itching, rash/scaling, acne/acneform eruptions were obviously improved (P < 0.05).
CONCLUSIONZPL could alleviate EGFRls associated adverse skin reactions, especially showed better effect on itching, rash/scaling, acne/acneform eruptions.
Antineoplastic Agents ; adverse effects ; Biomedical Research ; Drugs, Chinese Herbal ; administration & dosage ; therapeutic use ; Exanthema ; chemically induced ; Humans ; Neoplasms ; drug therapy ; Pruritus ; Receptor, Epidermal Growth Factor ; antagonists & inhibitors ; Skin ; drug effects ; Skin Diseases ; drug therapy
10.Observation on effect of badu shengji san and its decomposed recipes on morphological changes of injured skin tissues in rats.
Rong HE ; Bo PENG ; Yanli LU ; Jie GAO ; Lianqiang HUI ; Jianrong LI
China Journal of Chinese Materia Medica 2012;37(6):715-718
OBJECTIVETo study the effect of Badu Shengji San (BDSJS) and its decomposed recipes on morphological changes of injured skin in rats.
METHODSD rats with injured skin were treated with BDSJS and its different decomposed recipes for consecutively 14 days. Morphological changes in the injured skin were observed by H&E staining.
RESULTMercury and lead-containing ingredients significantly decreased epidermal thickness and caused vascular hemorrhage, hyperemia and inflammatory cell infiltration in reticular layer of dermis. The compatible herbs alleviated epidermal thickness and reduced dermal lesions.
CONCLUSIONBDSJS' mercury and lead-containing ingredients can accelerate the healing of skin wound and its compatible herbs can relieve the dermis injury induced by mercury and lead.
Animals ; Drugs, Chinese Herbal ; chemistry ; pharmacology ; toxicity ; Epidermis ; drug effects ; injuries ; pathology ; Hemorrhage ; chemically induced ; Hyperemia ; chemically induced ; Lead ; toxicity ; Male ; Mercury ; toxicity ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; Skin ; drug effects ; injuries ; pathology ; Skin Diseases ; drug therapy ; pathology ; Wound Healing ; drug effects