Objective To study the effect of small incision plus tubular stomach on serum vascular endothelial growth factor(VEGF) and quality of life in patients with esophageal cancer.Methods 78 patients with esophageal cancer were randomly divided into two groups,the control group (n =36 cases) and the observation group (n =42cases).The patients in the control group were treated through the conventional operation,while the patients in the observation group were treated through small incision plus tubular stomach.Serum VEGF and quality of life were detected.Results Qualities of life in both two groups were improved after operation and it in the observation group was higher than that in the control group (t =4.36,P ＜ 0.05).Serum VEGF in both two groups were decreased after operation (t =26.11,12.28,all P ＜ 0.01).It in the observation group was lower than that in the control group (t =14.94,P ＜ 0.05).Conclusion Small incision plus tubular stomach can significantly improve serum VEGF and quality of life in patients with esophageal cancer.

BACKGROUND:Hyperhomocysteine can be caused by 5,10-methylene tetrahydrofolate reductase (MTHFR) gene mutation, and HHcy is the independent risk factor for cerebral stroke.
OBJECTIVE:To study the correlation between plasma homocysteine level and polymorphisms of MTHFR gene C677T of young people in Shenzhen area, and to explore the relationships of plasma hyperhomocysteine level with other clinical indicators.
METHODS:A total of 101 cases with hyperhomocysteine were col ected as experimental group, and 101 cases with normal homocysteine level served as control group (20-45 years old). Genomic DNA was extracted with magnetic nanoparticles method from mouth swab samples of 202 cases. Then the DNA was amplified into target gene fragment by PCR, and amplification product was then sequenced.
RESULTS AND CONCLUSION:The frequencies of CC, CT, TT genotype of MTHFR C677T showed significant differences between the experimental group and the control group (P<0.01). This evidence indicates that the polymorphisms of MTHFR gene C677T can influence plasma homocysteine level of young people in Shenzhen area;TT genotype frequencies and T al ele frequencies in the experimental group were higher than that of control group. Besides, the plasma homocysteine level of TT genotype was significantly higher than that of CT genotype and CC genotype in the experimental group (P<0.05). We can conclude that TT genotype can improve the homocysteine level more than CT genotype;The systolic blood pressure and diastolic blood pressure in the experimental group were significantly higher than that in the control group (P<0.05). It indicated that hyperhomocysteine can induce the elevation of blood pressure level;but it is not sure that hyperhomocysteine can increase cholesterol level in our study.