1.Medical education smart classroom designing aided by artificial intelligence
Lin ZHOU ; Jiefu DENG ; Haojin ZHUANG ; Siyi LIU ; Mengyun LIANG
Modern Hospital 2024;24(8):1302-1305
Under the"New Medicine"context,how to integrate medical engineering technology into modern teaching methods has become a key approach to enhancing the quality and efficiency of medical education.This paper aims to advance medical education and teaching reforms,promote the comprehensive improvement in the quality of higher education,and focus on enhancing the quality of medical talent cultivation.For this purpose,the authors proposed an innovative intelligent classroom teaching model,based on artificial intelligence technology.This model utilized advanced camera technology to capture students'facial expressions in real-time,combining artificial intelligence algorithms to analyze students'understanding of medical concepts,and assisted teachers in adjusting classroom teaching strategies in real-time to improve learning effectiveness.This approach has significantly enhanced the overall quality and efficiency of medical education and is of great significance for cultivating versatile medical professionals with high levels of expertise and practical skills.
2.Cux1+ proliferative basal cells promote epidermal hyperplasia in chronic dry skin disease identified by single-cell RNA transcriptomics
Minhua HUANG ; Ning HUA ; Siyi ZHUANG ; Qiuyuan FANG ; Jiangming SHANG ; Zhen WANG ; Xiaohua TAO ; Jianguo NIU ; Xiangyao LI ; Peilin YU ; Wei YANG
Journal of Pharmaceutical Analysis 2023;13(7):745-759
Pathological dry skin is a disturbing and intractable healthcare burden,characterized by epithelial hy-perplasia and severe itch.Atopic dermatitis(AD)and psoriasis models with complications of dry skin have been studied using single-cell RNA sequencing(scRNA-seq).However,scRNA-seq analysis of the dry skin mouse model(acetone/ether/water(AEW)-treated model)is still lacking.Here,we used scRNA-seq and in situ hybridization to identify a novel proliferative basal cell(PBC)state that exclusively expresses transcription factor CUT-like homeobox 1(Cux1).Further in vitro study demonstrated that Cux1 is vital for keratinocyte proliferation by regulating a series of cyclin-dependent kinases(CDKs)and cyclins.Clinically,Cux1+PBCs were increased in patients with psoriasis,suggesting that Cux1+ PBCs play an important part in epidermal hyperplasia.This study presents a systematic knowledge of the tran-scriptomic changes in a chronic dry skin mouse model,as well as a potential therapeutic target against dry skin-related dermatoses.