Objective To investigate the status of social adjustment in undergraduate nursing students, and to explore the influence of interpersonal relations and social support on social adjustment. Methods A total of 485 undergraduate nursing students in the School of Nursing of University of South China were investigated by using the Comprehensive Diagnostic Scale for Interpersonal Relations, Social Support Rating Scale and Chinese College Students' Adaptability Scale with stratified cluster sampling method. Results The total scores of social adjustment of undergraduate nursing students were (195.37 ± 26.63) points. The total scores of interpersonal relations were (9.18 ± 5.81) points. The total scores of social support were (36.72 ± 5.39) points. Social support and social adjustment were positively correlated (r=0.274, P<0.01), but interpersonal relations and social adjustment were negatively correlated (r=-0.490, P<0.01). The main influencing factors of social adjustment in a descending order included interpersonal dating(β=-0.390, P=0.000), interpersonal conversation(β=-0.146, P =0.024) and subjective support(β=0.133, P =0.005). Conclusions The scores of the social adjustment, social support and interpersonal relations of undergraduate nursing students are all in the middle level. The main influencing factors of social adjustment include interpersonal dating, interpersonal conversation and subjective support, particulally interpersonal dating. Educators can improve their social adjustment through improving interpersonal dating, interpersonal conversation and subjective support .

Objective To evaluate the relationship between sevoflurane-induced cognitive impairment and α1B adrenoceptors (ADRA1B) and ADRA1D in the cerebral cortex of rats.Methods Forty-eight SPF adult Sprague-Dawley rats (half male,half female),weighing 220-260 g,were divided into control group (C group,n =24) and sevoflurane group (S group,n =24) using a random number table method.Group C and group S inhaled air and 3％ sevoflurane,respectively,for 5 h.Eight rats in each group were sacrificed immediately after anesthesia,and the cerebral cortex was removed.Eight rats in each group were selected on days 1 and 7 after anesthesia and underwent Barnes maze test.The rats were then sacrificed,and the cerebral cortex was removed.The expression of ADRA1B and ADRA1D protein and mRNA in cerebral cortex tissues was detected by Western blot and fluorescent quantitative real-time polymerase chain reaction,respectively.Results Compared with group C,the number of entering incorrect holes was significantly increased at 1 and 7 days after anesthesia,the latency and total distance to enter the target hole were prolonged,and the expression of ADRA1B and ADRA1D protein and mRNA in cerebral cortex was down-regulated immediately after anesthesia and at 1 and 7 days after anesthesia in group S (P＜0.05).Conclusion The mechanism underlying sevoflurane-induced cognitive impairment may be related to the down-regulated expression of ADRA1B and ADRA1D in cerebral cortex of rats.

【Objective】 To explore the effects of dapnetin’s regulation of STING/TBK1/IRF3 signaling pathway on immune inflammatory response in sepsis rats. 【Methods】 In this study, 80 male Sprague Dawley (SD) rats were selected and randomly divided into four groups, 20 rats in the sham-operation group, the remaining 60 mice with sepsis were constructed according to cecal ligation puncture (CLP) method and were intraperitoneally injected with different doses of dapnetin. They were divided into no-dapnetin model group (0 mg/kg), low-dose group (2.5 mg/kg), and high-dose group (5 mg/kg), with 20 mice in each group. The model group and sham-operation group were intraperitoneally injected with 0.1% DMSO. The survival rate of rats in each group after 72 h of CLP modeling was observed. Lung, kidney, liver and spleen tissues were collected for histopathological analysis. Serum inflammatory factors (TNF-α, IL-6, and IL-1β) were detected by ELISA, T lymphocyte subsets in peripheral blood were detected by flow cytometry, and STING/TBK1/IRF3 signaling pathway protein expression was detected by Western blotting. 【Results】 Compared with sham-operation group, the survival rate of rats in model group was reduced (P<0.05), each organ tissue injury was significant, serum inflammatory factors (TNF-α, IL-6, and IL-1β) levels were increased (P<0.05), CD4⁺ ratio and CD4⁺/CD8⁺ ratio in peripheral blood were decreased (P<0.05), while CD8⁺ ratio and Th1/Th2 ratio were increased (P<0.05), the protein expressions of STING, p-TBK1/TBK1 and p-IRF3/IRF3 were downregulated (P<0.05). Compared with the model group, dapnetin in high-dose group improved the survival rate of rats (P<0.05), the injury of all organs and tissues was reduced, and the level of serum inflammatory factors was decreased (P<0.05), CD4⁺ ratio and CD4⁺/CD8⁺ ratio in peripheral blood were increased (P<0.05), while CD8⁺ ratio and Th1/Th2 ratio were decreased (P<0.05), the protein expressions of STING, p-TBK1/TBK1 and p-IRF3/IRF3 were increased (P<0.05). 【Conclusion】 Dapnetin can improve the immune inflammatory response of sepsis rats by regulating STING/TBK1/IRF3 signaling pathway.

Objective To investigate the dietary patterns of rural residents in the high-incidence areas of esophageal cancer (EC), and to explore the clustering and influencing factors of risk factors associated with high-incidence characteristics. Methods A special structured questionnaire was applied to conduct a face-to-face survey on the dietary patterns of rural residents in Yanting county of Sichuan Province from July to August 2021. Univariate and multivariate logistic regression models were used to analyze the influencing factors of risk factor clustering for EC. Results There were 838 valid questionnaires in this study. A total of 90.8% of rural residents used clean water such as tap water. In the past one year, the people who ate fruits and vegetables, soybean products, onions and garlic in high frequency accounted for 69.5%, 32.8% and 74.5%, respectively; the people who ate kimchi, pickled vegetables, sauerkraut, barbecue, hot food and mildew food in low frequency accounted for 59.2%, 79.6%, 68.2%, 90.3%, 80.9% and 90.3%, respectively. The clustering of risk factors for EC was found in 73.3% of residents, and the aggregation of two risk factors was the most common mode (28.2%), among which tumor history and preserved food was the main clustering pattern (4.6%). The logistic regression model revealed that the gender, age, marital status and occupation were independent influencing factors for the risk factors clustering of EC (P<0.05). Conclusion A majority of rural residents in high-incidence areas of EC in Yanting county have good eating habits, but the clustering of some risk factors is still at a high level. Gender, age, marital status, and occupation are influencing factors of the risk factors clustering of EC.