Objective To investigate the clinical value of the bedside color Doppler in the assessment infants with periventricular-intraventricular hemorrhages (PIVH).Methods Sixty-eight cases of PIVH newborns and 156 healthy newborns were involved in the study,dynamic monitoring were undergone within a week after birth.The middle cerebral artery(MCA) hemodynamic parameters of velocity systolic (Vs),velocity diastolic(Vd) and resistance index (RI) were recorded,and the differences of the parameters were compared between different grades as well as those of the normal newborns at 1 d,4 d and 7 d after born.Results Total 68 PIVH infants were diagnosed by bedside color Doppler accurately.Prevalences of premature and low birth weight infants were higher than term infants and normal birth weight children,respectively (P ＜0.05).Vs and Vd of 4 groups of children with PIVH showed an increasing trend in a week after born.The differences of Vs between grade Ⅰ and normal newborns in 4 d and 7 d were not statistically significant (P＞ 0.05),the differences of the other three groups compared with normal newborn group in1 d,4 d and 7 d were statistically significant (P ＜0.05).Vd of grade Ⅱ newborns within 7 d were greater than those of other 4 groups (P ＜0.05),grade Ⅲ and grade Ⅳ within 7 d were less than healthy newborns (P ＜0.05).The difference of RI between all groups were not statistically significant (P ＞ 0.05).Conclusions The diagnostic accuracy rate of PIVH by bedside Doppler is high and the dynamic monitoring of neonatal hemodynamics could provide an important basis for assessing the occurrence and development of PIVH.

Objective To study the effect of model nurse election on satisfaction degree with nursing. Methods A model nurse election group was set up to carry out objective assessment, recommendation from doctors, nurses and patients, and feedback. The results in the satisfaction of doctors, nurses and patients were compared between before and after the activity. Results The satisfaction rate of doctors , nurses and patients after implementation of model nurse election were all significantly higher than before the implementation (P<0.05). Conclusion model nurse election used in the nursing management can help to improve nursing management effectiveness, drive continuous improvement of nursing quality, build harmonious doctor-patient relationship, and ultimately enhance satisfaction of doctors, nurses and patients.

Cytochrome P450 is a superfamily of metabolic enzymes and many of its members show tight correlation to the development of a variety of tumors.Cytochrome P450s are becoming novel research targets for personalized diagnosis and treatment because of its specialized enzymatic activity.This paper reviews the research progress and development of the cytochrome P 450 family in cancer field ,introduces the applications of cytochrome P 450 in clinical diagnosis and personalized medicine , looks into prospect research and application trend.

Objective To evaluate hepatectomy for liver metastasis in patients of gastric carcinoma.Methods Clinical data of 32 gastric cancer cases undergoing hepatectomy for hepatic metastatic tumor were reviewed retrospectively from 2006 to 2012.16 cases underwent radical gastrectomy and synchronous hepatectomy for liver metastasis,the remaining 16 cases underwent radical resection of gastric cancer and liver resection heterochronously.The relationship between prognosis and clinicopathology was analyzed.Results The overall survival rates were 84％,50％ and 37％ in 1 year,3 years and 5 years.The median survival time was 32 months.Gastric cancer invasion depth,intravascular tumor thrombi,lymphatic metastasis and intraoperative blood transfusion was related to poor prognosis by single factor analysis,while gastric serosal invasion,tumor thrombus and liver metastasis tumor ＞ 5 cm related to poor prognosis by multiple factors analysis.Conclusions Gastric cancer patients with liver metastasis who underwent hepatic resection can achieve good prognosis if hepatic metastatic tumor ＜ 5cm or the primary gastric cancer does not invade the serosa and without tumor thrombus.

Objective:To study crown-root morphology of maxillary anterior teeth in ClassⅡ,division 2 malocclusion using cone-beam CT (CBCT)combined with computer aided measurement technology to provide guidance for clinical treatment.Methods:The samples which consisted of 36 cases radiographed with CBCT techniques were selected and divided into two groups (1 8 each )based on the type of maloc-clusion presented:ClassⅡ,division 2 group (groupⅡ2)and ClassⅠgroup (groupⅠ).The measure-ments of crown-root morphology including crown-root angle and surface-shaft angle were got by Multiple Planer Reconstruction of CBCT data uploaded into InvivoDental software 5.0.The data were processed with SPSS 20.0 software package and t test was employed for comparison of angular measurements. Results:In group Ⅰ,crown-root angles of maxillary central incisor,maxillary lateral incisor and maxillary canines were 1 79.08°±3.31 °,1 76.55°±2.77°and 1 84.20°±2.51 °respectively, surface-shaft angles were 21 .00°±2.63°,1 9.63°±2.35°and 1 9.36°±2.30°respectively. While in group Ⅱ 2 ,crown-root angles of maxillary central incisor,maxillary lateral incisor and maxillary canines were 1 76.80°±2.62°,1 74.1 3°±3.28°and 1 81 .79°±2.88°respectively, surface-shaft angles were 23.20°±2.95°,22.29°±2.1 9°and 20.61 °±2.34°respectively. Compared with group Ⅰ,significant statistical differences were observed with the exception of sur-face-shaft angle of maxillary incisor.There was significant difference in crown-root angle between group Ⅱ2 and 1 80 °.Conclusion:The maxillary anterior teeth in ClassⅡ,division 2 malocclusion exhibited significant crown-root morphology which would influence the torque after orthodontic treat-ment.Special attention should be paid to the position of maxillary anterior teeth roots during ortho-dontic treatment for Class Ⅱ,division 2 malocclusion.The ideal position of tooth movement should be decided by the root rather than the location of the crowns.

Objective To observe the morphological changes of corneal nerve in experimental herpes simplex keratitis (HSK) in rabbit eyes. Methods Inoculation of the scarified cornea with herpes simplex virus-Ⅰ(HSV-Ⅰ)leads to herpetic infection of cornea. The HSK was detected by slit lamp and polymerase chain reaction(PCR), and the changes of corneal nerves in various periods with methylene blue vital staining and ultrastructure of corneal nerve were studied. Results Under light microscope, fewer corneal nerve bundles were observed, scattered with lower density of nerve fiber at center of cornea on the 4th day after the infection. At days 7 and 14, the seriously damaged nerve fiber was intermittent. The neuraxon became shorter with little polarity and the density of nerve fiber was extremely low. At day 30, the density was still low while the nerve fiber was approximately normal. Under electromicroscope, at day 4, the lamellar sheath of nerve fiber in the epitheliums appeared intermittent, and the neuroplasm of endings was partly lysed. During day 7 to day 14,neuroplasm was damaged and became vacuolar. The mitochondria swelled with vacuolar crest, and then were destroyed and lysed. The nerves in stroma were also injured. On day 30, neurilemma sheath was still intermittent with the decrease of microfilament and racuole. Conclusion HSK leads to the damage of nerve and the decrease of nerval density, and the damage of corneal nerve repairs very slowly.

Objective: To compare short-term efficacy of enhanced phase-I cardiac rehabilitation and ordinary phase-Ⅰ cardiac rehabilitation in patients after coronary artery bypass grafting (CABG). Methods: A total of 254 patients received CABG in our hospital from 2015-07 to 2015-10 were enrolled including 196 male and 58 female at the mean age of (59.92±7.80) years. Relevant health education was conducted and echocardiography, emotion, grip strength were assessed before operation. Based on personal aspiration, the patients were assigned to 2 groups at the 1st day after CABG: Enhanced phase-I cardiac rehabilitation (Enhanced) group, the patients received every day one to one training by physical therapist for 7 days and Ordinary phase-I cardiac rehabilitation (Ordinary) group, the patients received unified instruction by physical therapist prior operation. Relevant parameters were compared between 2 groups at 1 week post-operation which were mainly focused on left ventricular ejection fraction (LVEF), emotional assessment as health questionnaire 9-items (PHQ-9), generalized anxiety disorder 7-items (GAD-7) and grip strength. Results: Before operation: LVEF, PHQ-9 scores, GAD-7 scores and grip strength were similar between 2 groups.1 week post-operation: compared with Ordinary group, Enhanced group had the higher LVEF (62.88±5.21) % vs (59.00±9.83) %, P<0.05; Enhanced group showed slightly lower PHQ-9, GAD-7 scores and slightly higher grip strength without statistic meaning. Conclusion: Enhanced phase-I cardiac rehabilitation presented slight superiority as improved LVEF which implied that even 1 week specific training may benefit CABG patients.

Objective To investigate the status and trends of prostate cancer mortality in China.Methods Prostate cancer data between 1998 and 2008 from the National Cancer Registration Center were collected,including the mortality of prostate cancer,the cumulative probability of dying from prostate cancer of males aged 0-74,composition and age-specific mortality.Comparing and analysing the status and trends of the mortality between urban and rural men.Results In 2008,the mortality of prostate cancer of chinese men was 4.07/100 000,the world's population age-standardized mortality rate was 2.44/100 000.The mortality cumulative risk of males aged 0-74 was 0.18％,accounting for 1.78％ of the mortality of men's malignant tumors.The mortality of urban males was about 2.7 times of that in rural areas.The results of age-specific mortality showed that the mortality of chinese males over the age of 70 ranked lth in the males genitourinary tumor.The average annual growth rate during 1998-2008 was 8.44％.The growth mortality rate of urban men with prostate cancer was higher than in rural areas,it was 2.49/100 000 and 0.96/100 000,but the average annual growth rate was lower than rural males,it was 7.86％ and 8.28％.The proportion of high age group was increased significantly in the age composition of the mortality over time.Conclusions In recent years,the mortality of prostate cancer has showed a obvious growth trend in China.Prostate cancer impacts Chinese men's health seriously.

With the improvement of people's living standard, all kinds of antibacterial matefiats have been rapidly developed. In this paper, some terms relative to antibacterial materials and kinds, the antibacterial mechanism of antibacterial metallic materials have been introduced, research actuality and production technology of antibacterial metallic materials have been summarized, and characteristic and application of antibacterial metallic materials have been summarized. In the end, a development prospect of antibacterial metallic materials research in the future is also described.

Objective To investigate the epidemic characteristics of prostate cancer in China. Methods The population-based cancer registration data between year 1988 and 2002 were collected from 30 cancer registries in China. The data from 11 registries with continuous record were analyzed using the software Joinpoint Regression Program 3.3.1, and the incidence of bladder cancer among 3 different periods (1988-1992, 1993-1997 and 1998-2002) were compared. Results The inci-dence of prostate cancer was 1.96, 3.09, 4. 36 per 100 000 during 1998-1992, 1993-1997 and 1998-2002, respectively. The up-trend of prostate cancer incidence was statistically significant, how-ever it is still lower in China compared with other parts of the world from 1993 to 1997. Conclusions The incidence of prostate cancer in China showed a significant upward trend year by year, and prostate cancer might be one of major cancer in China. We should pay attention to it.