Objective To investigate the clinical value of the bedside color Doppler in the assessment infants with periventricular-intraventricular hemorrhages (PIVH).Methods Sixty-eight cases of PIVH newborns and 156 healthy newborns were involved in the study,dynamic monitoring were undergone within a week after birth.The middle cerebral artery(MCA) hemodynamic parameters of velocity systolic (Vs),velocity diastolic(Vd) and resistance index (RI) were recorded,and the differences of the parameters were compared between different grades as well as those of the normal newborns at 1 d,4 d and 7 d after born.Results Total 68 PIVH infants were diagnosed by bedside color Doppler accurately.Prevalences of premature and low birth weight infants were higher than term infants and normal birth weight children,respectively (P ＜0.05).Vs and Vd of 4 groups of children with PIVH showed an increasing trend in a week after born.The differences of Vs between grade Ⅰ and normal newborns in 4 d and 7 d were not statistically significant (P＞ 0.05),the differences of the other three groups compared with normal newborn group in1 d,4 d and 7 d were statistically significant (P ＜0.05).Vd of grade Ⅱ newborns within 7 d were greater than those of other 4 groups (P ＜0.05),grade Ⅲ and grade Ⅳ within 7 d were less than healthy newborns (P ＜0.05).The difference of RI between all groups were not statistically significant (P ＞ 0.05).Conclusions The diagnostic accuracy rate of PIVH by bedside Doppler is high and the dynamic monitoring of neonatal hemodynamics could provide an important basis for assessing the occurrence and development of PIVH.

Cytochrome P450 is a superfamily of metabolic enzymes and many of its members show tight correlation to the development of a variety of tumors.Cytochrome P450s are becoming novel research targets for personalized diagnosis and treatment because of its specialized enzymatic activity.This paper reviews the research progress and development of the cytochrome P 450 family in cancer field ,introduces the applications of cytochrome P 450 in clinical diagnosis and personalized medicine , looks into prospect research and application trend.

Objective To study the effect of model nurse election on satisfaction degree with nursing. Methods A model nurse election group was set up to carry out objective assessment, recommendation from doctors, nurses and patients, and feedback. The results in the satisfaction of doctors, nurses and patients were compared between before and after the activity. Results The satisfaction rate of doctors , nurses and patients after implementation of model nurse election were all significantly higher than before the implementation (P<0.05). Conclusion model nurse election used in the nursing management can help to improve nursing management effectiveness, drive continuous improvement of nursing quality, build harmonious doctor-patient relationship, and ultimately enhance satisfaction of doctors, nurses and patients.

Objective To evaluate hepatectomy for liver metastasis in patients of gastric carcinoma.Methods Clinical data of 32 gastric cancer cases undergoing hepatectomy for hepatic metastatic tumor were reviewed retrospectively from 2006 to 2012.16 cases underwent radical gastrectomy and synchronous hepatectomy for liver metastasis,the remaining 16 cases underwent radical resection of gastric cancer and liver resection heterochronously.The relationship between prognosis and clinicopathology was analyzed.Results The overall survival rates were 84％,50％ and 37％ in 1 year,3 years and 5 years.The median survival time was 32 months.Gastric cancer invasion depth,intravascular tumor thrombi,lymphatic metastasis and intraoperative blood transfusion was related to poor prognosis by single factor analysis,while gastric serosal invasion,tumor thrombus and liver metastasis tumor ＞ 5 cm related to poor prognosis by multiple factors analysis.Conclusions Gastric cancer patients with liver metastasis who underwent hepatic resection can achieve good prognosis if hepatic metastatic tumor ＜ 5cm or the primary gastric cancer does not invade the serosa and without tumor thrombus.

Objective To investigate the epidemic characteristics of prostate cancer in China. Methods The population-based cancer registration data between year 1988 and 2002 were collected from 30 cancer registries in China. The data from 11 registries with continuous record were analyzed using the software Joinpoint Regression Program 3.3.1, and the incidence of bladder cancer among 3 different periods (1988-1992, 1993-1997 and 1998-2002) were compared. Results The inci-dence of prostate cancer was 1.96, 3.09, 4. 36 per 100 000 during 1998-1992, 1993-1997 and 1998-2002, respectively. The up-trend of prostate cancer incidence was statistically significant, how-ever it is still lower in China compared with other parts of the world from 1993 to 1997. Conclusions The incidence of prostate cancer in China showed a significant upward trend year by year, and prostate cancer might be one of major cancer in China. We should pay attention to it.

Objective To investigate the epidemic characteristics of bladder cancer in China.Methods The population-based cancer registration data from 1988 to 2002 were collected from 30 cancer registries in China.The data from 11 registries with continuous record were analyzed using the software Joinpoint Regression Program 3.3.1,and the incidence of bladder cancer among 3 different periods(1988-1992,1993-1997 and 1998-2002)were compared. Results The incidence of bladder cancer was 8.22,9.45 and 9.68 per 100,000 during 1988-1992,1993-1997 and 1998-2002,respectively.The up-trend of bladder cancer incidence was statistically significant,however it was still lower in China compared with other parts of the world from 1993 to 1997. Conclusions Bladder cancer is the most common cancer in malignant neoplasm of male genitalurinary system in China.The incidence of bladder cancer in China showed an upward trend in the past 15 years and more attention is needed.

Objective To investigate the epidemic characteristics of malignant neoplasm of kidney and other urological malignancies in China. Methods The population-based cancer registration data between 1988 and 2002 were collected from 30 cancer registries in China.The data from 11 registries with continuous record were analyzed using the software Joinpoint Regression Program 3.3.1.The incidences of kidney cancer among 3 different periods(1988-1992,1993-1997 and 1998-2002)were compared. Results The incidence of renal cancer and other urological malignancies was 4.26 ,5.40,6.63 per 100 000 population during 1988-1992,1993-1997 and 1998-2002,respectively.The up-trend of kidney cancer incidence was statistically significant;however it was still lower in China than other parts of the world from 1993 to 1997. Conclusion The incidence of kidney cancer in China showed an upward trend in the past 15 years and more attention is needed.

Objective To observe the morphological changes of corneal nerve in experimental herpes simplex keratitis (HSK) in rabbit eyes. Methods Inoculation of the scarified cornea with herpes simplex virus-Ⅰ(HSV-Ⅰ)leads to herpetic infection of cornea. The HSK was detected by slit lamp and polymerase chain reaction(PCR), and the changes of corneal nerves in various periods with methylene blue vital staining and ultrastructure of corneal nerve were studied. Results Under light microscope, fewer corneal nerve bundles were observed, scattered with lower density of nerve fiber at center of cornea on the 4th day after the infection. At days 7 and 14, the seriously damaged nerve fiber was intermittent. The neuraxon became shorter with little polarity and the density of nerve fiber was extremely low. At day 30, the density was still low while the nerve fiber was approximately normal. Under electromicroscope, at day 4, the lamellar sheath of nerve fiber in the epitheliums appeared intermittent, and the neuroplasm of endings was partly lysed. During day 7 to day 14,neuroplasm was damaged and became vacuolar. The mitochondria swelled with vacuolar crest, and then were destroyed and lysed. The nerves in stroma were also injured. On day 30, neurilemma sheath was still intermittent with the decrease of microfilament and racuole. Conclusion HSK leads to the damage of nerve and the decrease of nerval density, and the damage of corneal nerve repairs very slowly.

OBJECTIVE:To compare the curative effect of domestic cefoperazone/sulbactam and imported one for lower respiratory infection. METHODS:The curative effects of domestice vs. imported cefoperazone/sulbactam in 201 vs. 198 patients with lower respiratory infection in recent two years in our hospital were analyzed retrospectively. RESULTS:The effective rate was 61.6% for imported product and 51.7% for domestic product. Significant difference was noted between 2 groups statistically(P

Objective: To compare short-term efficacy of enhanced phase-I cardiac rehabilitation and ordinary phase-Ⅰ cardiac rehabilitation in patients after coronary artery bypass grafting (CABG). Methods: A total of 254 patients received CABG in our hospital from 2015-07 to 2015-10 were enrolled including 196 male and 58 female at the mean age of (59.92±7.80) years. Relevant health education was conducted and echocardiography, emotion, grip strength were assessed before operation. Based on personal aspiration, the patients were assigned to 2 groups at the 1st day after CABG: Enhanced phase-I cardiac rehabilitation (Enhanced) group, the patients received every day one to one training by physical therapist for 7 days and Ordinary phase-I cardiac rehabilitation (Ordinary) group, the patients received unified instruction by physical therapist prior operation. Relevant parameters were compared between 2 groups at 1 week post-operation which were mainly focused on left ventricular ejection fraction (LVEF), emotional assessment as health questionnaire 9-items (PHQ-9), generalized anxiety disorder 7-items (GAD-7) and grip strength. Results: Before operation: LVEF, PHQ-9 scores, GAD-7 scores and grip strength were similar between 2 groups.1 week post-operation: compared with Ordinary group, Enhanced group had the higher LVEF (62.88±5.21) % vs (59.00±9.83) %, P<0.05; Enhanced group showed slightly lower PHQ-9, GAD-7 scores and slightly higher grip strength without statistic meaning. Conclusion: Enhanced phase-I cardiac rehabilitation presented slight superiority as improved LVEF which implied that even 1 week specific training may benefit CABG patients.