Objective To investigate the clinicopathological features and survival prognosis of adenocarcinoma of esophagogastric junction(AEG)patients with metabolic syndrome(MS).Methods The clinicopathological data of 135 patients who underwent radical gastrectomy for AEG in the First Affiliated Hospital of Xinjiang Medical University from January 2014 to December 2019,40 cases with MS were selected as the case group,and 95 cases without MS as the control group,so as to explore the clinicopathological features and survival prognosis of AEG patients with complicated with MS.Results There were statistically significant differences in the age,body mass index(BMI),fasting blood-glucose,triglyceride and high-density lipoprotein cholesterol between the case group and the control group(P<0.05),while there were no significant differences in the gender,postoperative adjuvant therapy,general type,invasion of nerves,formation of cancer embolus in vessels,degree of differentiation,depth of invasion,lymph node metastasis,expression of human epidermal growth factor receptor 2(HER2)and clinical TNM stage between the two groups(P>0.05).After adjusting for related con-founding factors,multivariate Logistic regression analysis showed that BMI was most closely correlated with AEG patients with MS,and the difference was statistically significant(P<0.001).AEG patients with BMI≥25kg/m2had an increased risk of MS(OR = 1.306,95%CI:1.135-1.501).Survival analysis showed that there was no statistically significant difference in overall survival time between the two groups(χ2 =0.042,P =0.857).Conclusion Advanced age,obesity,hyperglycemia and hyperlipidemia are the typical clinical char-acteristics of AEG patients with MS,among which′BMI is the most closely related,suggesting that the risk of MS is significantly increased in AEG obese patients.