Objective Systematically reviewed the standard treatment of primary brain glioma patients high levels,and discussed effective new therapies. Surgery,radiotherapy and chemotherapy are the main methods of treatment of high?grade gliomas, molecular markers supplement clinical prognostic factors under certain circumstances be able to guide treatment decisions. The rapid development of technology using molecular data can improve our understanding of the disease pathogenesis and proliferation. Effectively validate prognostic biomarkers and identification of tumor may improve the outcome.