1.The olloimrnunizotion rote of onti-c concurrent with onti-E in R1R1 potients.
Hyun Ok KIM ; Hyo Jun AHN ; Yong Bin EOM ; Jung Sin LEE ; Min Ja CHOI
Korean Journal of Blood Transfusion 1996;7(2):181-186
Anti-E and anti-c is one of the clinical significant irregular antibodies developing a delayed hemolytic transfusion reaction and hemolytic disease of the newborn. Since anti-c occurs frequently with anti-E in immunized people whosoe cells are E-and c-, it has been recommended to select blood of the patient's own R1 phenotype for transfusion, even when the presence of anti-c cannot be demonstrated in his/her serum. To determine the utility of this approach, we reviewed the blood bank laboratory records of patients identified anti-E and anti-c in his/her serum in Severance hospital over a 12 year period (1985-1996). During the 12-year period of study, 53 patients were identified with anti-E and/or anti-c; 30(56.6%) patients had anti-E alone, 6(11.3%) had anti-c, and 17(32.1%) had both. Thirty eight of forty two patients whose Rh-hr phenotypes were tested were R1R1. Of these 38 R1R1 patients, 16 patients (42.1%) presented with anti-c concomitant with anti-E. Ouru study showed that the incidence of antni-c in R1R1 patients with anti-E is similar to that of studies reported in Caucasian groups. We highly suggest the transfusion protocol of prophylactic use of c negative blood for R1R1 patients with anti-E. Furthermore, because anti-c may be present in concentrations too low to be detected, the enzyme technique is recommended in parallel with standard serologic methods for the identification of irregular antibodies.
Antibodies
;
Blood Banks
;
Blood Group Incompatibility
;
Humans
;
Incidence
;
Infant, Newborn
;
Phenotype
2.Drug Abuse Status and Its Determinants of Male High School Students in Taegu.
Jung Rak NAM ; Sin KAM ; Jae Yong PARK ; Chang Hyun HAN ; Young Ae HA
Korean Journal of Preventive Medicine 1996;29(3):451-470
To identify the drug abuse status and its determinant factors in high school boys in Taegu, the study was performed from April to May, 1995. Study population were selected by cluster sampling method and total 5,665 students replied to the self-administered questionnaire survey(2,207 in academic high school, 3,458 in business high school). The major findings were as follows; The proportion of drinking, smoking experience was 55.0%, 45.8%, respectively, and the proportion of current drinker, current smoker was 27.2%, 27.5%. The drinking, smoking experience rate of second grade students was higher than first grade and it was higher in business high school boys. The proportion of a stimulant, a hallucinogen, hemp leaf cigarets experience was 3.2%, 1.6%, 0.1%, respectively. Drug abuse had significant association with home environment(lower economic status, frequent move, death of father or mother, apart from family), parents environment(parents' indifference, parents' drinking and smoking, etc.), school life(lower school grades, intimate friend's drug abuse, etc.), generous attitude to drug abuse, higher level of stress. Students who replied that the law prohibited immature person(students) from drinking and smoking showed lower drug abuse rate. In multiple logistic regression analysis, second grade students, business high school students, parents' indifference, lower school grades, intimate friend's drug abuse, no recognition of the fact that the law prohibits high school students from drinking and smoking, generous attitude to drug abuse, higher level of stress were significantly related with alcohol abuse and smoking. Other drugs abuse were related with above factors. On consideration of above findings, to prevent students from drug abuse, we have to try together in house, school, and society.
Alcoholism
;
Cannabis
;
Commerce
;
Daegu*
;
Drinking
;
Fathers
;
Humans
;
Jurisprudence
;
Logistic Models
;
Male*
;
Mothers
;
Parents
;
Surveys and Questionnaires
;
Smoke
;
Smoking
;
Substance-Related Disorders*
3.Open heart surgery 600 cases for 5 years.
Kwang Hyun CHO ; Yoon Ho WHANG ; Yang Haeng LEE ; Jong Weon PARK ; Sin Hyun JUNG ; Kang Ju CHOI
The Korean Journal of Thoracic and Cardiovascular Surgery 1991;24(4):404-420
No abstract available.
Heart*
;
Thoracic Surgery*
4.Effects of Alcohol on Neurocognitive Function, Psychomotor Performance and Subjective Response in Koreans with Different ALDH2 Genotypes.
Il Seon SIN ; Jin Sang YOON ; Hyun KIM ; Hyung Yung LEE ; Bo Hyun YOON ; Hoon LEE ; Jae Sung JUNG
Journal of the Korean Society of Biological Psychiatry 1999;6(2):176-188
OBJECTIVE: The purpose of this study was to evaluated the effects of alcohol on neurocognitive function, psychomotor performance and subjective response in healthy Korean adults with different ALDH2 genotypes. METHOD: A total of 24 males, half with active ALDH2*1/2*1 and the other with inactive ALDH2*1/2*1, was selected through genotyping using restriction fragment length polymorphism. In a double-blind, placebo-controlled cross-over design, each subject consumed 0.5g/kg dose of alcohol, given as a mixture of 40% vodka and orange juice, and placebo(orange juice) on two separate occasions on an average of weekly intervals. The blood alcohol concentrations(BACs) were measured using a breath analyzer at baseline and at 30, 60 minutes after drinking. P300s were measured at baseline and at 30 minutes after alcohol and placebo intake. Vital signs and psychomotor performance[Critical Flicker Fusion Threshold(CFFT), Choice Reaction Time(CRT), Digit Symbol Substitution(DSS)] were measured at baseline and at 60 minutes after alcohol and placebo intake. Subjective responses were measured at the end of the study. The statistical analysis focused on whether there were any differences between groups with different ALDH2 genotypes. RESULTS: The major results are as follows. 1) BACs in inactive group were overall equivalent to those in the active group. Only in terms of time, BACs were significantly higher overall at 30 minutes than at 60 minutes after alcohol intake. 2) Pulse rates were significantly increased after alcohol intake compared with placebo, and the increase was greater in the inactive than in the active group. 3) P300 latencies in leads Fz(frontal), Cz(cental) and Pz(parietal) were significantly increased after alcohol intake compared to placebo, and the increase was greater in the inactive than in the active group. P300 amplitudes in leads Cz and Pz were significantly decreased overall after alcohol intake compared to placebo. 4) Compared with placebo, alcohol produced significant effect on the psychomotor performance : impairment in the inactive group, improvement in the active group. 5) Compared with placebo, alcohol significantly induced a negative or an intense effect on the subjective responses in the inactive group, but little negative and even a somewhat positive effect in the active group. CONCLUSIONS: These results suggest that ALDH isozyme variance might be an important factor to determine the effects of acute dose of alcohol on the various psychobehavioural functions and also to determine the alcohol use pattern and to predict the future development of alcohol overuse and/or abuse.
Adult
;
Citrus sinensis
;
Cross-Over Studies
;
Drinking
;
Flicker Fusion
;
Genotype*
;
Heart Rate
;
Humans
;
Male
;
Polymorphism, Restriction Fragment Length
;
Psychomotor Performance*
;
Vital Signs
5.A Subgaleal Hematoma Accompanying Exophthalmos.
Baek Hyun LEE ; Sin JUNG ; Kyu Yong CHO ; Min Suk OH
Journal of Korean Neurosurgical Society 1991;20(6):471-473
A case of subgaleal hematoma accompanying ipsilateral exophthalmos is reported. The exophthalmos is due to orbital extension of subgaleal hematoma through potential gap between orbital septum and the lateral horn of the levator palpebral aponeurosis. We must remember that exophthalmos is able to occur after subgaleal hematoma.
Animals
;
Craniocerebral Trauma
;
Exophthalmos*
;
Hematoma*
;
Horns
;
Orbit
6.Study of the Mechanism for the Growth Inhibitory Effects of Conjugated Linoleic Acid on Caco-2 Colon Cancer Cells.
Eun Ji OH ; Yoon Sin OH ; Hyun Sook LEE ; Hyun Suh PARK ; Jung Han YOON
The Korean Journal of Nutrition 2003;36(3):270-279
Conjugated linoleic acid (CLA) is a group of positional and geometric isomers of linoleic acid (LA) and exhibits anticarcinogenic activity in a variety of animal models. We have previously observed that CLA inhibited the growth of Caco-2 cells, a human colon adenocarcinoma cell line. The present study was performed to determine whether the growth inhibitory effect of CLA is related to change in secretion of IGF- II and/or IGF-binding proteins (IGFBPs) that have been shown to regulate Caco-2 cell proliferation by an autocrine mechanism. Cells were incubated in serum-free medium with various concentrations of CLA or linoleic acid (LA). Immunoblot analysis of 24-hours, serum-free, conditioned medium using a monoclonal anti-IGF-IIantibody revealed that Caco-2 cells secreted both mature 6,500 Mr and higher Mr forms of pro IGF-II. The levels of pro IGF-II and mature IGF-IIwere decreased by 43+/-2% and 53+/-6%, respectively by treatment with 50 micrometer CLA. LA slightly increased pro IGF- II levels. Results from Northern blot analysis showed that CLA decreased IGF-II mRNA levels at 50 micrometer concentration suggesting that CLA regulation of IGF-II protein expression occurs partly at the transcriptional level. Ligand blot analysis of conditioned media using 1251-IGF-II revealed that CLA slightly decreased IGFBP-2 levels and increased IGFBP-4 levels. We confirmed our previous results that CLA inhibited cell growth in a dose-dependent manner but LA slightly increased cell growth. Exogenous IGF-II mitigated the growth inhibitory effect of CLA. These results indicate that the growth inhibitory effect of CLA may be at least in part mediated by decreasing IGF-II and IGFBP-2 secretion and increasing IGFBP-4 secretion in Caco-2 cells.
Adenocarcinoma
;
Blotting, Northern
;
Caco-2 Cells
;
Cell Line
;
Colon*
;
Colonic Neoplasms*
;
Culture Media, Conditioned
;
Humans
;
Insulin-Like Growth Factor Binding Protein 2
;
Insulin-Like Growth Factor Binding Protein 4
;
Insulin-Like Growth Factor Binding Proteins
;
Insulin-Like Growth Factor II
;
Linoleic Acid*
;
Models, Animal
;
RNA, Messenger
7.Solitary Jejunal Tuberculosis with Intestinal Obstruction in an Immunocompetent Patient.
Hyun Jin BAE ; Jong Ho PARK ; Su Sin JIN ; Jiyun JUNG ; Yun Jung NAM ; Da Won KIM
Korean Journal of Medicine 2018;93(6):556-559
Intestinal tuberculosis is an infection of the gastrointestinal tract by the Mycobacterium tuberculosis complex. To the best of our knowledge, solitary intestinal tuberculosis accompanied by intestinal obstruction, particularly in the middle of the small intestine, is extremely rare. We report a case of solitary jejunal tuberculosis in a 49-year-old man with no underlying disease. He was admitted a few days after the onset of diffuse abdominal discomfort. Upon evaluation, we initially considered a malignancy of the distal jejunum with ileus due to the presence of a mass. Therefore, he underwent laparoscopic resection of the small bowel. Unexpectedly, the histologic specimen showed a chronic caseating granulomatous lesion with acid-fast bacilli. Ultimately, he was diagnosed with solitary jejunal tuberculosis. He was successfully treated with anti-tuberculosis drugs without any complications.
Gastrointestinal Tract
;
Humans
;
Ileus
;
Immunocompetence
;
Intestinal Obstruction*
;
Intestine, Small
;
Jejunum
;
Middle Aged
;
Mycobacterium tuberculosis
;
Tuberculosis*
;
Tuberculosis, Gastrointestinal
8.The Clinical Effects of Early Trophic Feeding in Extremely Low Birth Weight Infants.
Ji Mi JUNG ; Seong Woo HAN ; Mi Lim CHUNG ; Soo Hyun KOO ; Ga Won JEON ; Jong Beom SIN
Korean Journal of Perinatology 2011;22(2):122-128
PURPOSE: This study investigated the effects of early enteral feeding on the morbidities of extremely low birth weight infants (ELBWI) weighing less than 1,000 g. METHODS: We conducted a retrospective review of the medical records of sixty one ELBWI who were admitted to the neonatal intensive care unit of Inje University Busan Paik Hospital from January 2007 to October 2009. ELBWI were divided into two groups; the control group included ELBWI from January 2007 to March 2008, for whom enteral feeding was started beyond 3 days and the early feeding group included ELBWI from April 2008 to October 2009, for whom enteral feeding was started within 3 days. RESULTS: Gestational age and birth weight did not differ between the two groups. In the early feeding group, start day of enteral feeding (control group vs. early feeding group; 7+/-2days vs. 2+/-1days), time to achieve full enteral feeding (68+/-6 days vs. 22+/-2 days), and the duration of parenteral nutrition (58+/-6 days vs. 22+/-2 days) were significantly shorter, and weight gain at postnatal day 28 was significantly higher than that of the control group (P<0.001). No differences were observed in the incidence of sepsis and necrotizing enterocolitis and duration of hospitalization; however, the incidence of total parenteral nutrition induced cholestasis (44% vs. 7%) and bronchopulmonary dysplsia (78% vs. 24%) was significantly lower in the early feeding group. CONCLUSION: Early enteral feeding in ELBWI shortened the time to achieve full enteral feeding, improved weight gain, and decreased the incidence of brochopulmonay dysplasia and cholestasis.
Birth Weight
;
Cholestasis
;
Enteral Nutrition
;
Enterocolitis, Necrotizing
;
Gestational Age
;
Humans
;
Incidence
;
Infant
;
Infant, Low Birth Weight
;
Infant, Newborn
;
Intensive Care, Neonatal
;
Medical Records
;
Parenteral Nutrition
;
Parenteral Nutrition, Total
;
Retrospective Studies
;
Sepsis
;
Weight Gain
9.One case of placenta increta successfully treated with methotrexate.
Myung sin KIM ; Hyun ui LEE ; Jung min YOON ; Kyu ri HWANG ; Hye won JUN
Korean Journal of Obstetrics and Gynecology 2008;51(11):1342-1346
Placenta increta is a kind of placental adhesion which can cause severe postpartum hemorrhage and life-threatening condition. It might necessitate a hysterectomy, but conservative management can be considerable for preserving reproductive potential when possible. A 34-years-old woman in her 41st week of pregnancy had normal full term spontaneous delivery. Retained placenta after removal by placenta forceps resulted in mild bleeding. Placenta increta was clinically diagnosed on computerized tomography. Remnant placenta in situ was nearly disappeared 2 months later after five-time intramuscular injection of 50 mg methotrexate and three-times curettage was done for conservative management.
Curettage
;
Female
;
Hemorrhage
;
Humans
;
Hysterectomy
;
Injections, Intramuscular
;
Methotrexate
;
Placenta
;
Placenta Accreta
;
Placenta, Retained
;
Postpartum Hemorrhage
;
Pregnancy
;
Surgical Instruments
10.Glomus Tumor of the Nasal Septum : A Case Report.
Dong Bin AHN ; Chang Min SIN ; Ji Hyun PARK ; Jung Soo KIM
Journal of Rhinology 2008;15(2):156-159
Glomus tumor is a benign tumor, which is believed to represent hyperplasia or harmatomatous development of the glomus body. It is relatively rare in the head and neck region, especially in the nasal cavity. Up to now, only about twenty cases of glomus tumor in the nasal cavity have been reported. We report a case of glomus tumor originating from the anterior portion of nasal septum, which was treated by local excision.
Glomus Tumor
;
Head
;
Hyperplasia
;
Nasal Cavity
;
Nasal Septum
;
Neck