1.The Correlation between the Duration of Breast Feeding and Iron Deficiency Anemia(IDA).
Yee Ja KANG ; Ha Sin PARK ; Hae Jin CHOEH ; Kyuchul CHOEH
Journal of the Korean Pediatric Society 1995;38(11):1453-1459
No abstract available.
Breast Feeding*
;
Breast*
;
Iron*
2.Changes of serum neutrophil chemotactic activity(NCA) and myeloperoxidase(MPO) level following lysine-aspirin(L-ASA) bronchoprovocation test in aspirin-sensitive asthmatic patients.
Sun Sin KIM ; Hee Yeon KIM ; Dong Ho NAM ; Ki Such JUNG ; Hae Sim PARK
Journal of Asthma, Allergy and Clinical Immunology 1999;19(2):181-187
BACKGROUND: There have been few reports suggesting involvement of mast cell and neutrophil to induce bronchoconstriction in aspirin-sensitive asthrna. OBJECTIVE: To evaluate mast cell and neutrophil activation in pathogenesis of aspirin-sensitive asthma. MATERIAL AND METHOD: We observed changes of serum NCA and MPO levels during L-ASA bronchoprovocation test in 14 subjects with aspirin-sensitive asthma. RESULTS: Serum NCA was significantly increased at 30 min(p=0.01) after the inhalation of L-ASA and then, no significant changes were noted at 240 min (p=0.14). NCA was significantly higher in subjects with late asthmatic responses than in those without it (p=0.04). Serum MPO level tended to increase at 30 min with no statistical significance (p=0.08), and then it significantly decreased at 240 min (p=0.05). There was no significant correlation between serum NCA and MPO level (r=0.22, p=0.58). CONCLUSION: These results support the view that NCA derived from mast cell may contribute to neutrophil recruitment into the airway in aspirin-sensitive asthmatic patients.
Asthma
;
Bronchoconstriction
;
Humans
;
Inhalation
;
Mast Cells
;
Neutrophil Activation
;
Neutrophil Infiltration
;
Neutrophils*
3.Clinical features of bee venom anaphylaxis.
Sung Gyun AHN ; Sun Sin KIM ; Hee Yeon KIM ; Dong Ho NAHM ; Hae Sim PARK
Journal of Asthma, Allergy and Clinical Immunology 1999;19(3):492-497
Background and OBJECTIVE: There has been a few case reports of anaphylaxis due to honeybee in Korea. In order to observe the clinical feature of bee sting anaphylaxis. Moderials and methods: Six patients living in Kyunggi province area were referred under history of anaphylaxis after the bee sting. Atopy was defined by skin prick test result to common inhalant allergen. Serum specific IgE antibody to each bee antigen was detected by radioimmunoassay to identify the causative bee. RESULTS: All six cases were female. Three had atopy and four had combined allergic diseases such as allergic rhinitis, asthma, and urticaria. The etiologic bees consisted of yellow jacket (6 cases), paper wasp (4 cases), yellow hornet (3 cases), white faced hornet (1 case) and honey bee (1 case). Four cases had experienced anaphylaxis after ant bite and they showed positive result on specific IgE to imported fire ant. Specific immunotherapy against causative bee venom was begun using bee venom extracts from Bayer (USA) based upon results of specific IgE anti-body to bee venom. CONCLUSION: The yellow jacket is the most common cause of bee venom anaphylaxis in this area. Further studies will be needed to evaluate possible cross-reactivity between bee and ant venom.
Anaphylaxis*
;
Ant Venoms
;
Ants
;
Asthma
;
Bee Venoms*
;
Bees*
;
Bites and Stings
;
Female
;
Fires
;
Gyeonggi-do
;
Honey
;
Humans
;
Immunoglobulin E
;
Immunotherapy
;
Korea
;
Radioimmunoassay
;
Rhinitis
;
Skin
;
Urticaria
;
Wasps
4.Perforated Duodenal Diverticulum after Distal Subtotal Gastrectomy and Billorth II Gastrojejunostomy.
Sung Bae JEE ; Sin Sun KIM ; Kyong Hwa JUN ; Wook KIM ; Kyong Sin PARK ; Hae Myung JEON
Journal of the Korean Gastric Cancer Association 2006;6(1):52-56
A 69-year old man presented with severe epigastric pain for 1 day. He had early gastric cancer at the antrum and underwent a distal subtotal gastrectomy and Billorth II gastrojejunostomy one month later without any post-operative complications. Radiologic examination revealed a large amount of retroperitoneal free air formation. Because of unremitting pain and unstable vital sign, exploratory laparotomy was followed. During the operation, a perforated duodenal diverticulum at the posterior wall of the 2nd portion of the duodenum was identified. He underwent diverticulectomy and primary closure. He was discharged on the 18th post operative day and has been followed up without any evidence of comlpication for several months.
Aged
;
Diverticulum*
;
Duodenum
;
Gastrectomy*
;
Gastric Bypass*
;
Humans
;
Laparotomy
;
Stomach Neoplasms
;
Vital Signs
5.A Case of Tetrasomy 9P.
Jeong Hae JOO ; Hong Sun JOO ; Son Sang SEO ; Sook Ja PARK
Journal of the Korean Society of Neonatology 1997;4(1):72-76
Supernumerary isochromosome resulting in autosomal tetrasomy are rare and have been described only for 12P, 18P, and 9P. Tetrasomy 9P, initially described by Ghymer et al, is a rare chromosomal aberration that has been described in 20 patients. Affected subjects show both cytogenetic and ohenotypic variability. Some patients have the abnormal cell line in all cells, but many display tissue limited mosaicism. The phenotype varies in severity from prenatal death to mild developmental delay and minor anomalies. We reported a infant with mild manifestations of tetrasomy 9p with brief review of related literatures.
Cell Line
;
Chromosome Aberrations
;
Cytogenetics
;
Humans
;
Infant
;
Isochromosomes
;
Mosaicism
;
Phenotype
;
Tetrasomy*
6.Pseudobacteremic Outbreak of Leclercia adecarboxylata and Pseudomons aeruginosa Related to Contaminated Saline Cotton .
Cheol Ho SIN ; Gyong Jung KIM ; Sehe Dong LEE ; Hae Jung NAM ; Choon Kwan KIM ; Seung Chul PARK
Korean Journal of Nosocomial Infection Control 2006;11(1):15-20
BACKGROUND: During a 1-month period in 2005 , a series of 4 Leclercia adecarboxylata and 8 Pseudomonas aeruginosa bacteremias were reported from patients admitted to the emergency room. METHODS: An outbreak of L. adecarboxylata and P. aeruginosa bacteremia that occurred from February to March 2005 was investigated. The infection control nurse reviewed medical records and observed the procedures of blood cultures at the clinical microbiology laboratory. Specimens were obtained for investigational cultures from alcohol sponge, tray, sink, water of sink, saline cotton, microscope, computer, and telephone. RESULTS: L. adecarboxylata was isolated from 4 patients and P. aeruginosa from 8 patients during a 1-month period. Observation of the culture procedure revealed that saline cotton was used to prevent betadin skin discoloration. The culture of the saline solution yielded a heavy growth of P. aeruginosa, which was not isolated from any other specimens. CONCLUSIONS: This was a pseudoepidemic caused by contaminated saline cotton. The use of the saline cotton was stopped, and during the follow-up period of 3 months, no additional L. adecarboxylata or P. aeruginosa bacteremia were reported.
Bacteremia
;
Emergency Service, Hospital
;
Enterobacteriaceae*
;
Follow-Up Studies
;
Humans
;
Infection Control
;
Medical Records
;
Porifera
;
Pseudomonas aeruginosa
;
Skin
;
Sodium Chloride
;
Telephone
;
Water
7.Determinant Factors for Expenditure of the Medical Insurance Program for Self-Employeds.
Sin KAM ; Jae Yong PARK ; Min Hae YEH
Korean Journal of Preventive Medicine 1995;28(1):153-173
This study was conducted to examine the determinant factors for expenditure of the medical insurance program for self-employeds based on the analysis of 1991 "The Medical Insurance program for self-Employeds Statical Yearbook", and also similar yearbooks in the metropolitan and other provinces. The major findings are as follows: We have divided benefits into these four components such as the utilization rate for out-patients. expenses per claim for out-patients as paid by the insurer, utilization rate for in-patients, and the expenses per claim for in-patients as paid by the insurer, in order to examine the determinant factors for it. The results of the study revealed the following findings: in urban areas, the supply of medical care had more influence on the benefits than other demographic and economic variables, while, in county areas, both the supply of medical care and the rate of those aged over 65 affected the provision of benefits. The determinant factors for financial balance of the medical insurance program for self-employeds are: first, the determinant factor for administrative expenses was the number of households. The more the number of household, the less the administrative expenses per the insured. This shows that the economy of scale is being. And so, the administrative district must be taken into consideration in the incorporation of small regional medical societies and should be re-organized for more efficient management. Second. in urban areas. the supply of medical care had more influence on utilization rate and expenses per claim as paid by insurer, and therefore it is necessary to control it. In county areas the supply of medical care and the rate of those aged over 65 raised the utilization rate and expenses per claim as paid by insurer. For the financial stability of county areas. a common fund for medical care for the aged and expansion of finance stabilization fund would be necessary. But, in county areas, it would be unnecessary to control the supply of medical care because it was much more insufficient than in urban areas. The vitalization of public health facilities must be carried out in county areas, for they reduced benefits. Since the more insured in a single household, the less the utilization of the medical insurance program, benefits for habilitation at home should be given consideration. The law of majority and the economy of scale were applied here, and therefore the incorporation of regional medical societies must be taken into consideration. In integrating regional medical societies, it would be absolutely necessary to review the structural differences among all regional medical societies, the medical demand of each region, and also the local characteristics of each region.
Family Characteristics
;
Financial Management
;
Health Expenditures*
;
Humans
;
Insurance Carriers
;
Insurance*
;
Jurisprudence
;
Outpatients
;
Public Health
;
Rehabilitation
;
Societies, Medical
8.Leukotriene C4 synthase promoter polymorphism in aspirin - induced asthma.
Jae Youn CHO ; Sang Yeub LEE ; Seon Ae HAN ; Se Hwa YOO ; Sun Sin KIM ; Hae Sim PARK ; Jung Won PARK ; Chein Soo HONG ; Kwang Ho IN
Journal of Asthma, Allergy and Clinical Immunology 1999;19(4):542-547
BACKGROUND: Aspirin/NSAIDs can release cysteinyl-leukotriene (cys-LTs) into airways and precipitate asthmatic symptoms in aspirin - induced asthma(AIA). It has been reported that there is profound overexpression of LTC4 synthase in their bronchial mucosa, compared to aspirin-tolerant asthma. Objective : We observed whether genetic polymorphism of LTC4 synthase may be predisposed to LTC4 synthase overexpression in AIA. Subject and METHOD: Forty - four AIA patients having positive responses on lysin aspirin bron choprovocation tests and 47 non - aspirin induced asthma ( non - AIA ) patients having negative challenges and 32 healthy controls were enrolled. The genotypes of the promoter LTC4 synthase gene ( A,C transversion ) were determined by polymerase chain reaction and restriction fragment length polymorphism ( RFLP ) method. RESULTS: LTC4 synthase promoter polymorphism ( A444C btransversion) was not significantly different between non - AIA and AIA patients (p>0.05). Conclusion These findings suggest that genetic polymorphism of LTC4 synthase promoter may not be predisposed to LTC, synthase overexpression in AIA.
Aspirin*
;
Asthma*
;
Asthma, Aspirin-Induced
;
Genotype
;
Humans
;
Leukotriene C4*
;
Mucous Membrane
;
Polymerase Chain Reaction
;
Polymorphism, Genetic
;
Polymorphism, Restriction Fragment Length
9.Overexpression of CD73 in epithelial ovarian carcinoma is associated with better prognosis, lower stage, better differentiation and lower regulatory T cell infiltration.
Hoon Kyu OH ; Jeong Im SIN ; Junghae CHOI ; Sung Hae PARK ; Tae Sung LEE ; Youn Seok CHOI
Journal of Gynecologic Oncology 2012;23(4):274-281
OBJECTIVE: The purpose of the current study was to evaluate survival outcome according to the expression status of CD73 in patients with epithelial ovarian cancer. METHODS: A total of 167 patients with epithelial ovarian cancer were enrolled in the current study. For each patient, a retrospective review of medical records was conducted. Immunohistochemical staining for CD73, CD8, FoxP3, and CD68 was performed using tissue microarray made with paraffin embedded tissue block. RESULTS: Among the enrolled patients, 29.9% of patients (n=50) showed negative expression for CD73, whereas 70.1% of patients (n=117) showed positive expression for CD73. The CD73 positive group showed better prognosis compared to the CD73 negative group (5-year overall survival of CD73 positive group, 73.0%; that of CD73 negative group, 50.1%; p=0.023). CD73 was more frequently expressed in mucinous adenocarcinoma and clear cell carcinoma compared to serous or endometrioid adenocarcinoma. In addition, CD73 overexpressions were more frequently detected in patients with known good prognostic factors, i.e., low stage, well/moderate differentiation, negative peritoneal cytology, no lymphovascular involvement, and no macroscopic residual tumor after debulking surgery. There was significantly more infiltration of regulatory T cells in the CD73 negative group compared to the CD73 positive group. CONCLUSION: Good prognosis in patients with overexpression of CD73 may be due to that overexpression of CD73 was more frequently observed in epithelial ovarian cancer patients with known good prognostic factors. Therefore, this result means that favorable differentiation and stage have more influence on survival outcome than adverse effect of CD73 per se.
5'-Nucleotidase
;
Adenocarcinoma, Mucinous
;
Carcinoma, Endometrioid
;
Humans
;
Medical Records
;
Neoplasm, Residual
;
Neoplasms, Glandular and Epithelial
;
Ovarian Neoplasms
;
Paraffin
;
Prognosis
;
Retrospective Studies
;
T-Lymphocytes, Regulatory
10.Overexpression of CD73 in epithelial ovarian carcinoma is associated with better prognosis, lower stage, better differentiation and lower regulatory T cell infiltration.
Hoon Kyu OH ; Jeong Im SIN ; Junghae CHOI ; Sung Hae PARK ; Tae Sung LEE ; Youn Seok CHOI
Journal of Gynecologic Oncology 2012;23(4):274-281
OBJECTIVE: The purpose of the current study was to evaluate survival outcome according to the expression status of CD73 in patients with epithelial ovarian cancer. METHODS: A total of 167 patients with epithelial ovarian cancer were enrolled in the current study. For each patient, a retrospective review of medical records was conducted. Immunohistochemical staining for CD73, CD8, FoxP3, and CD68 was performed using tissue microarray made with paraffin embedded tissue block. RESULTS: Among the enrolled patients, 29.9% of patients (n=50) showed negative expression for CD73, whereas 70.1% of patients (n=117) showed positive expression for CD73. The CD73 positive group showed better prognosis compared to the CD73 negative group (5-year overall survival of CD73 positive group, 73.0%; that of CD73 negative group, 50.1%; p=0.023). CD73 was more frequently expressed in mucinous adenocarcinoma and clear cell carcinoma compared to serous or endometrioid adenocarcinoma. In addition, CD73 overexpressions were more frequently detected in patients with known good prognostic factors, i.e., low stage, well/moderate differentiation, negative peritoneal cytology, no lymphovascular involvement, and no macroscopic residual tumor after debulking surgery. There was significantly more infiltration of regulatory T cells in the CD73 negative group compared to the CD73 positive group. CONCLUSION: Good prognosis in patients with overexpression of CD73 may be due to that overexpression of CD73 was more frequently observed in epithelial ovarian cancer patients with known good prognostic factors. Therefore, this result means that favorable differentiation and stage have more influence on survival outcome than adverse effect of CD73 per se.
5'-Nucleotidase
;
Adenocarcinoma, Mucinous
;
Carcinoma, Endometrioid
;
Humans
;
Medical Records
;
Neoplasm, Residual
;
Neoplasms, Glandular and Epithelial
;
Ovarian Neoplasms
;
Paraffin
;
Prognosis
;
Retrospective Studies
;
T-Lymphocytes, Regulatory