Mutations in the p53 gene seem to be the most common genetic changes in human malignancies. Mutation or altered p53 expression is a common occurrence in many solid neoplasms, including head and neck carcinomas. Recent studies have also shown p53 alterations in several premalignant conditions of the colon, esophagus, lung, and brain. Preliminary data have suggested that p53 mutations may be involved in tumor progression. This study was performed to determine the incidence of p53 mutations in histologically 27 squamous cell carcinomas, 19 basal cell carcinomas, 18 Schneiderian papillomas, 3 Schneiderian papillomas with malignant transformation, and 15 pleomorphic adenomas of the head and neck region. The degree of p53 gene overexpression was also evaluated according to differentiation, histologic type of tumor, and tumor progression in the head and neck carcinomas. The results were as follows; 1) Eighteen of 27 squamous cell carcinomas, and 4 of 27 dysplasias adjacent to the squamous cell carcinoma of the head and neck expressed p53 protein, but none of the normal control specimens expressed detectable p53 protein. There was no relationship between differentiation of squamous cell carcinoma and p53 protein expression. 2) Twelve of 19 basal cell carcinomas expressed p53 protein; the adenoid type especially overexpressed p53 protein. 3) Nine of 15 pleomorphic adenomas expressed p53 protein especially in the epithelial components. 4) Thirteen of 18 Schneiderian papillomas and all Schneiderian papillomas with malignant transformation expressed p53 protein. The above results indicate that the p53 protein expression is a useful tool for the prediction of tumor progression in the head and neck tumor, but there was no relationship between the differentiation of the tumor and p53 protein expression.
Humans ; Incidence ; Adenoma ; Genes, p53

Parovarian cysts constitute 10% of adnexal masses. They were found in broad ligament and mostly arise from mesothelium and less commonly from paramesonephric element and rarely from mesonephric element. In most cases parovarian cysts were asymptomatic. So, they were found incidentally at surgery for other conditions. Torsion is infrequent and it is difficult to distinguish it from torsion of other adnexal masses, appendicitis, etc. Recently, we experienced a voluminous parovarian cyst undergoing torsion, 25 cm in diameter. The case is presented with a review of literature.
Appendicitis ; Broad Ligament ; Epithelium ; Female ; Parovarian Cyst*

Blue nevus of the uterine cervix is a rare benign pigmented lesion consisting of dermal melanocytes in the stroma. It is similar to those of common blue nevus of the skin. Most of these are clinically or colposcopically unsuspected and an incidental finding often found in hysterectomy specimens. The case here was incidentally found in surgical pieces after hysterectomy in 43-year-old women performed for leiomyoma. We report a case of blue nevus of the uterine cervix with a review of the literature.
Adult ; Cervix Uteri* ; Female ; Humans ; Hysterectomy ; Incidental Findings ; Leiomyoma ; Melanocytes ; Nevus, Blue* ; Skin

Condyloma acuminatum is a manifestation of human papillomavirus (HPV) infection. The genital warts tend to occur in areas most directly affected by coitus, namely external genitalia, perineum and perianal areas. The warts are highly contagious; more than 75% of sexual partners develop when exposed. The warts frequently increase in number and size during pregnancy, sometimes filling the vagina or covering the perineum, making it difficult to perform vaginal delivery or episiotomy. Probably small number of infants and children born of women with genital warts will become infected and develop laryngeal papillomatosis. We have experienced one case of huge condyloma acuminatum during pregnancy and presented with a brief review of literature.
Child ; Coitus ; Condylomata Acuminata ; Episiotomy ; Female ; Genitalia ; Humans ; Infant ; Papilloma ; Perineum ; Pregnancy* ; Sexual Partners ; Vagina ; Warts

Abdominal pregnancy is a rare form of extrauterine pregnancy which is account for 1.4% of all ectopic pregnancy cases. Among these omental pregnancy is extremely rare and may cause life-threatening massive hemorrhage as a complication. But the diagnosis of early abdominal pregnancy is difficult because of non specific findings about clinical history, physical examination and ultrasonography. Risk factors related to ectopic pregnancy include inflammation, infection and surgery, but endometriosis is an uncommon factor. We present a case of the ruptured primary omental pregnancy associated with endometriosis with a review of the literature.
Diagnosis ; Endometriosis* ; Female ; Hemorrhage ; Inflammation ; Physical Examination ; Pregnancy ; Pregnancy, Abdominal* ; Pregnancy, Ectopic ; Risk Factors ; Ultrasonography

OBJECTIVE: Post-traumatic hydrocephalus (PTH) is a frequent and serious complication following brain injury. The incidence of PTH varies greatly among studies. The purpose of this study was to investigate the incidence and treatment of PTH in patients with head trauma. METHODS: We examined 956 patients with head trauma who visited our center from January 2012 to December 2015. The hydrocephalus diagnosis was based on radiologic findings and clinical features, and patients were classified into the mild (Group 1, Glasgow Coma Scale score [GCS] 13–15), moderate (Group 2, GCS 9–12), or severe (Group 3, GCS 3–8) brain injury group according to their GCS at admission. To compare these groups, we used age, gender, radiologic findings, PTH developmental period, and postoperative results (Glasgow Outcome Scale). RESULTS: Of the 956 patients, 24 (2.5%) developed PTH. PTH occurred in 11 (1.4%), 3 (5.6%), and 10 (7.0%) patients in Groups 1, 2, and 3, respectively. Of the 24 patients with PTH, 22 (91.7%) developed PTH within 12 weeks post-trauma; the higher the GCS, the later the onset, and the lower the GCS, the earlier the onset (p=0.019). Twenty-one patients underwent ventriculoperitoneal shunting, and 13 had improved symptoms. CONCLUSION: The incidence of PTH cannot be ignored. The possibility of PTH needs to be considered in patients with head trauma and appropriate follow-up should be undertaken. PTH is a treatable complication and patients' quality of life and neurological status can be improved if the appropriate treatment is selected and applied.
Brain Injuries ; Craniocerebral Trauma* ; Diagnosis ; Follow-Up Studies ; Glasgow Coma Scale ; Head* ; Humans ; Hydrocephalus* ; Incidence ; Quality of Life ; Ventriculoperitoneal Shunt

Cervical pregnancy is a rarely life-threatening form of ectopic pregnancy in which the implantation of the developing conceptus in the cervical canal. The cervix is composed predominantly of the fibrous tissue. Therefore cervical pregnancy can be massive hemorrhagic occurrence from the eroded blood vessels within the cervical tissue. In the past, as a result of life-threatening hemorrhage, the diagnosis of a cervical ectopic pregnancy frequently led to hysterectomy. Currently, several conservative treatments are possible with the hope of preserving future reproductive potential, including preoperative uterine artery embolization before dilatation and evacuation. We report a case of cervical pregnancy which was treated sucessfully with preoperative selective uterine artery embolization before dilatation and currettage.
Blood Vessels ; Cervix Uteri ; Cytochrome P-450 CYP1A1 ; Diagnosis ; Dilatation ; Female ; Hemorrhage ; Hope ; Hysterectomy ; Pregnancy* ; Pregnancy, Ectopic ; Uterine Artery Embolization* ; Uterine Artery*

gp130-mediated signaling is involved in both chondrogenesis and osteogenesis, but its direct role in the formation of embryonic Meckel's cartilage and associated mandibular development has not yet been elucidated. In this study, we examined the influence of gp130 ablation on the developing mandibular Meckel's cartilage by evaluating the morphological and histological changes as well as the gene expression patterns in developing embryonic gp130-/- mice. The ablation of the gp130 gene showed no change in region-specific collagen mRNA expression except for a slight delay in its expression but caused shortened embryonic Meckel's cartilage, delayed hypertrophic chondrocyte maturation and subsequent bony replacement with characteristic bending of the intramandibular Meckel's cartilage. The bending of Meckel's cartilage led to a narrow mandibular arch at the rostral area with poor cortical plate formation. These findings indicate that gp130-mediated signaling is important for the normal morphogenesis of Meckel's cartilage and subsequent mandibular development.
Animals ; Body Patterning ; Cartilage/embryology/metabolism/*physiology ; Collagen ; Cytokine Receptor gp130/genetics/*physiology ; Mandible/embryology/metabolism/*physiology ; Mice ; Mice, Knockout

BACKGROUND: Horse antithymocyte globulin (ATG) is a useful treatment for aplastic anemia and for bone marrow transplantation from HLA-mismatched donors. Mortality due to anaphylactic reaction to horse ATG has been reported. We evaluated the clinical significance of skin test and specific IgE measurement for the prediction of immediate type hypersensitivity reaction to horse ATG. SUBJECTS AND METHODS: The study subjects consisted of 25 patients who received horse ATG. Underlying diseases of the 25 patients included aplastic anemia (n=20), leukemia (n=3), lymphoma (n=1), and Gaucher's disease (n=1). Skin prick test was done on these patients using undiluted ATG solution (Upjohn, USA) with duplication. Specific IgE to ATG was detected by enzyme-linked immunosorbent assay and immunoblot analysis. RESULTS: Skin prick test was positive in 7 (28%) of 25 patients. None of the patients showing negative skin prick test experienced immediate type hypersensitivity reaction to ATG. All patients showing positive skin prick test received desensitization before the administration of a full dose of ATG. However, 3 of 7 patients showing positive skin prick test experienced immediate type hypersensitivity reaction; one of them died of anaphylaxis. Specific IgE measurement using enzyme-linked immunosorbent assay was not useful in predicting immediate type hypersensitivity reaction to ATG because of nonspecific bindings. Specific IgE measurement using immunoblot analysis was only positive in the one patient who died of anaphylaxis. CONCLUSION: Skin prick test was clinically useful in the prediction of immediate type hypersensitivity reaction to horse ATG, but specific IgE measurement was not. Further studies might be needed to develop an in vitro test for the prediction of immediate type hypersensitivity reaction to horse ATG.
Anaphylaxis ; Anemia, Aplastic ; Antilymphocyte Serum* ; Bone Marrow Transplantation ; Enzyme-Linked Immunosorbent Assay ; Gaucher Disease ; Horses* ; Humans ; Hypersensitivity* ; Immunoglobulin E* ; Leukemia ; Lymphoma ; Mortality ; Skin Tests* ; Skin* ; Tissue Donors

Burkitt's lymphoma is a distinct clinical entity classified as an undifferentiated lymphoma of B-lymphocytic origin. Burkitt's lymphoma cell leukemia occurs when Burkitt's lymphoma cells represent more than 20% of marrow cells and exceed about 5000/ul in blood. We report a case of Burkitt's lymphoma cell leukemia in primary gastric lymphoma in 55-year-old man with 5kg of weight loss for 2 months and epigastric pain for 3 days. Primary gastric lymphoma was diagnosed by biopsies with gastrofiberoscopy and upper abdominal CT scan in this patient. During admission, peripheral blood smear revealed sudden increase in abnormal blasts with multiple vacuoles. Burkitt's lymphoma cell leukemia was diagnosed by peripheral blood smear, bone marrow aspiration and biopsy, immunophenotyping and cytogenetic analysis in this patient. For its great rarity, we report this case with review of literature.
Biopsy ; Bone Marrow ; Burkitt Lymphoma* ; Cytogenetic Analysis ; Humans ; Immunophenotyping ; Leukemia* ; Lymphoma* ; Lymphoma, Non-Hodgkin ; Middle Aged ; Tomography, X-Ray Computed ; Vacuoles ; Weight Loss