1.Historical perspective and recent progress in cardiac ion channelopathies research and clinical practice in Hong Kong
Keith Sai KIT LEUNG ; Helen HUANG ; Cheuk To CHUNG ; Danny RADFORD ; Ishan LAKHANI ; Christien Ka HOU LI ; Tommy Wai KEI LI ; Simon RANJITHKUMAR ; Rajesh RAJAN ; Leonardo ROEVER ; Sebastian GARCIA‑ZAMORA ; George BAZOUKIS ; Tong LIU
International Journal of Arrhythmia 2023;24(2):9-
Cardiac ion channelopathies encompass a set of inherited or acquired conditions that are due to dysfunction in ion channels or their associated proteins, typically in the presence of structurally normal hearts. They are associated with the development of ventricular arrhythmias and sudden cardiac death. The aim of this review is to provide a historical perspective and recent advances in the research of the cardiac ion channelopathies, Brugada syndrome, long QT syn‑ drome and catecholaminergic polymorphic ventricular tachycardia, in Hong Kong, China. In particular, recent works on the development of novel predictive models incorporating machine learning techniques to improve risk strati‑ fication are outlined. The availability of linked records of affected patients with good longitudinal data in the public sector, together with multidisciplinary collaborations, implies that ion channelopathy research efforts have advanced significantly.
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