ObjectiveTo assess the epidemic characteristics of serum of viral hepatitis type B(hepatitis B for short)infection in Jilin Province in 2020.MethodsIn 2020,1 667 people ranging in age from 1 to 69 years in Jilin Province were selected by using multi-stage random sampling method for field epidemiological investigation of hepatitis B. The serum samples were collected and detected for the hepatitis B virus(HBV)surface antigen(HBsAg),HBV surface antibody(HBsAb),HBV core antibody(HBcAb),HBV E antigen(HBeAg)and HBV E antibody(HBeAb)by ELISA,and the data were analyzed by the national epidemiological dynamic data collection platform,SPSS 18.0 software.ResultsThere were significant differences in hepatitis B vaccination rates across age groups surveyed in 2020（χ2= 810. 48,P < 0. 05）.In 2020,the HBsAg carrying rate,HBsAb positive rate,HBV infection rate,HBeAb positive rate and HBeAg positive rate of people at the age of 1-69 years in Jilin Province were 0. 96%,59. 99%,15. 66%,7. 02% and 0. 18%,respectively.ConclusionIn 2020,the indicators of HBV infection in Jilin Province were good,and the high vaccination rate of people should continue to be maintained,and the vaccination of hepatitis B vaccine for adults should be strengthened to reduce the risk of infection in these susceptible groups.

Objective:This study aimed to analyze the genomic characteristics of Varicella-Zoster Virus (VZV) strains circulating in Jilin province from 2010 to 2023.Methods:Vesicle fluid from 78 sporadic cases with VZV infection were collected in Jilin province from 2010 to 2023, after detecting by Real-time PCR, 26 specimens (CT<25) were detected by PCR. Open reading frame 22(ORF22), ORF38 and ORF62 were amplified and analyzed. Genotyping was confirmed by SNPs ORF22 (37902, 38019, 38055, 38081 and 38177) and ORF38 (69424). Vaccine strains were indentified from wild-type strains according to ORF38 (69349) and ORF62 (106262, 107252, and 108111). Sequences were analyzed by homologous comparison and phylogenetic analysis.Results:The comparison with Dumas sequence revealed that SNPs (37902, 38055, 38081 and 38177) in ORF22 and ORF38 (69424) have mutations similar to the pOka strain, which belong to clade 2. Compared to the Dumas and Baike strains, all 26 samples were wild-type strains. JL2016-4 strain changes from threonine to asparaginyl at position 38059, JL2021-4 strain changes from arginine to proline at position 37933, from aspartic acid to tyrosine at position 37935, and from aspartic acid at base 38031 to tyrosine. JL2023-1 strain changes from arginine to leucine at position 37933.Conclusions:VZV has been prevalent for 14 years in Jilin province. The main epidemic strains belong to the clade 2. We should strengthen the monitoring of VZV outbreaks and raise the coverage rate of VZV vaccination.