1.Misdiagnosis of pneumoconiosis or silicotuberculosis in China: a pooled analysis of 1178 cases.
Xiang-pei LÜ ; Huan-qiang WANG
Chinese Journal of Industrial Hygiene and Occupational Diseases 2013;31(8):564-567
OBJECTIVETo investigate the situation and causes of misdiagnosis of pneumoconiosis or silicotuberculosis in China by pooled analysis, and to provide a reference for the clinical diagnosis of pneumoconiosis in China and reduce the misdiagnosis rate.
METHODSA computer search was performed to collect the studies on the misdiagnosis of pneumoconiosis or silicotuberculosis published in China from 1985 to 2013. The obtained data were subjected to pooled analysis to investigate the causes of misdiagnosis and seek the measures for reducing misdiagnosis.
RESULTSFifty-nine studies involving 1178 cases of misdiagnosed pneumoconiosis or silicotuberculosis were collected. There were 13 causes of misdiagnosis, and the most common one was the poor ability of identification due to inadequate experience in reading chest X-ray films (45.93%), followed by neglect of patient's occupational history (44.99%). Other causes of misdiagnosis included complex X-ray findings that are difficult to judge (29.03%), poor quality of chest radiographs (23.09%), and lack of regular health supervision (19.95%).
CONCLUSIONInadequate experience of physicians is the main cause of misdiagnosis of pneumoconiosis or silicotuberculosis. To reduce misdiagnosis of the disease, measures should be taken to enhance the training and evaluation of knowledge and skills of diagnosis and differential diagnosis of pneumoconiosis among physicians.
China ; Diagnostic Errors ; Female ; Humans ; Male ; Pneumoconiosis ; diagnosis ; Silicotuberculosis ; diagnosis
5.Study on drug-resistance of Mycobacterium tuberculosis isolated from coal workers with silico-tuberculosis.
Ping JIANG ; Hongmin LI ; Dongjin CHEN ; Wei WANG ; Bai FENG ; Zhongyuan WANG ; Guoyang WANG ; Sumei LI ; Huixin HAN
Chinese Journal of Industrial Hygiene and Occupational Diseases 2002;20(2):100-102
OBJECTIVETo study the gene mutation and streptomycin, isoniazid or rifampicin resistance of Mycobacterium isolated from silico-tuberculosis patient's sputum so as to find a more effective therapy for this disease.
METHODSMycobacteria tuberculosis were separated from 96 coal worker with silico-tuberculosis firstly. Then rpsL, KatG and rpoB fragments of genome were copied with PCR and compared their SSCP profiles with standard strains.
RESULTS67 strains of streptomycin, isoniazid or rifampicin resistant Mycobacteria tuberculosis were found in routine drug resistance test, with the percentages of 80.5% (54/67), 58.2% (39/67) respectively. PCR-SSCP showed that out of 67 drug-resistant strains, 66(98.5%) of rpsL, 47(70.1%) of rpoB and 42(62.7%) of KatG appeared abnormal.
CONCLUSIONMost of the resistant strains appeared gene mutation. The mution rates were higher than the results from routine drug resistance test.
Coal ; Drug Resistance, Bacterial ; Humans ; Mutation ; Mycobacterium tuberculosis ; drug effects ; genetics ; Polymerase Chain Reaction ; Polymorphism, Single-Stranded Conformational ; Silicotuberculosis ; microbiology ; Sputum ; microbiology
6.Misdiagnosis in one patient with pneumosilicosis combined with pulmonary tuberculosis and aspergillosis.
Yan-Sheng GUAN ; Yan-Song ZHANG ; Yan-Ping ZHAO
Chinese Journal of Industrial Hygiene and Occupational Diseases 2007;25(1):45-46
Adult
;
Aspergillosis
;
diagnosis
;
etiology
;
Diagnostic Errors
;
Humans
;
Lung Diseases, Fungal
;
diagnosis
;
etiology
;
Male
;
Silicosis
;
diagnosis
;
microbiology
;
Silicotuberculosis
;
diagnosis
;
etiology
;
Tuberculosis, Pulmonary
;
diagnosis
;
etiology