400 cases of senile constipation were treated by Shenshen Bolus, a self-formulated remedy of Qi-benefitting, Yin-nourishing, blood-benefitting and blood-activating nature with a total effective rate of 98.0%. Experiments showed that as compared with Maren(Fructus Cannabis)Bolus, Shenshen Bolus not only possesses better cathartic action and lowers the tension of intestine in vitro. but also strengthens the function of the kidney. It reveals no side effects even in long-term administration.

Objective:To discuss effect of nicorandil on unstable angina patients With persistent Weakly positive for troponin I (TnI).Methods:A total of 111 unstable angina patients With persistent Weakly positive for TnI Were randomly divided into control group (received routine treatment,55 cases) and intervention group (received nic-orandil 5mg,3 times/d based on routine treatment,56 cases).The relief of chest pain in one Week,the recurrent hospitalization for chest pain aggravation in 3 months and the cardiac mortality rate in one year betWeen tWo groups Were observed in tWo groups. Results:Compared With control group,the relief of angina pectoris in one Week (63.6% vs. 91.1%,χ2=11.97,P=0.0005)significantly increased,re-hospitalization for chest pain aggravation in three months (56.4% vs.19.6%,χ2=15.91,P=0.0001)significantly decreased in intervention group;but cardiac mortality rate during one year betWeen tWo groups Was no significant difference (5.5% vs. 8.9%,χ2=0.50,P=0.4792).Conclusion:Nicorandil can significantly reduce the unstable angina and re-hospitalization for chest pain aggravation in patients With persistent Weakly positive for TnI,but there Was no significant difference in reducing mortality Within one year betWeen tWo groups.

Objective: To understand the attitudes and perceptions of traditional Chinese medicine (TCM) practitioners in Beijing TCM hospitals regarding the use of Ephedra sinica Stapf (E. sinica, Ma Huang). Methods: A two-stage cross-sectional study was conducted using a questionnaire survey of TCM practitioners in Beijing TCM hospitals between April 2023 and March 2024. The questionnaire included demographic information, the clinical background of TCM practitioners, and the clinical application of E. sinica. Logistic regression analysis was used to analyze the relevant influencing factors when using E. sinica. Results: Of the 465 questionnaires collected, 441 were valid. Among these, 84.81% (374/441) reported having used E. sinica in clinical practice at least once. The commonly used doses of E. sinica—excluding the pediatric department—were 10 g for high doses, 6 g for medium, and 3 g for low. The three most frequently used formulas for E. sinica included Maxing Shigan decoction, Mahuang decoction, and Xiao Qing Long decoction. The most common TCM patterns treated with a high dose of E. sinica were wind-cold exterior pattern, wind-cold invading the lung, and wind and water combat with meridians congealed by cold. The top three Western medical diagnoses when using E. sinica for treatment were common cold, pneumonia, and upper respiratory tract infections. Nearly half of the respondents reported experiencing adverse reactions from the oral administration of E. sinica, with the most common being palpitations, insomnia, and restlessness. Starting with a low dose and gradually increasing it as appropriate was identified as an effective approach. Conclusion This study investigated the attitudes and perceptions of TCM practitioners in Beijing TCM hospitals regarding the dose–efficacy–adverse reaction relationship of E. sinica, providing a reference for the safe and effective clinical use of E. sinica.

Objective To summarize the effect of acupoint massage on blood pressure in hypertensive pregnant women and its outcomes.Methods A total of 70 pregnancy induced hypertension women were randomly divided into two groups,35 cases in the control group were given routine nursing measures and 35 cases in the observation group were given acupoint massage therapy,blood pressure control and pregnancy outcomes were compared.Results After the intervention,systolic pressure,diastolic pressure,serum creatinine,urea nitrogen and urinary albumin of two groups were significantly decreased (P ＜ 0.05).Systolic blood pressure,diastolic blood pressure,serum creatinine,urea nitrogen and urinary albumin in the observation group were significantly lower than that in the control group (P ＜ 0.05).All the pregnant women were followed up until delivery,and the two groups had no maternal and neonatal death cases.The observation group had higher natural delivery rate,and lower fetal distress and pregnancy induced hypertension rate were than the control group (P ＜0.05).Conclusion The acupuncture point massage has positive function on blood pressure control for pregnancy induced hypertension,and it can significantly improve the pregnancy outcomes of pregnant women.

Objective To study the effect of self-management diary on blood glucose control and pregnancy outcomes in pregnant women with gestational diabetes mellitus.Methods The clinical data of 72 pregnant women with gestational diabetes mellitus admitted in our hospital were retrospectively analyzed.According to the different nursing intervention patterns, the patients were divided into control group and observation group.Pregnant women of two groups were given supportive treatment of conventional symptomatic drugs.Pregnant women in the control group were given routine general nursing interventions to guide their healthy dietary in their families, and the pregnant women in observation group were given self-management diary nursing intervention, therapeutic efficacy in blood glucose control compliance rate and pregnancy outcomes were compared.Results The levels fasting blood glucose, Postprandial 2 h blood glucose and glycosylated hemoglobin after intervention in two groups were statistically significant (P<0.05).The control level of blood glucose in observation group was better than the control group(P<0.05).The level of serum C-peptide (fasting serum C-peptide and postprandial 2 h peptide) in the observation group was significantly better than that in the control group (P <0.05).The cesarean section rate and mother-infant health indices of the observation group were significantly better than that in the control group, the differences were statistically significant(P<0.05).Conclusion Nursing intervention model is of great significance to improve the nursing quality of the whole hospital.Implementation of self-intervention model of pregnant women can not only effectively control gestational diabetes mellitus of pregnant women and significantlyreduce rate of cesarean section;so it is worthy of clinical application.

Objective To summarize the effect of acupoint massage on blood pressure in hypertensive pregnant women and its outcomes.Methods A total of 70 pregnancy induced hypertension women were randomly divided into two groups,35 cases in the control group were given routine nursing measures and 35 cases in the observation group were given acupoint massage therapy,blood pressure control and pregnancy outcomes were compared.Results After the intervention,systolic pressure,diastolic pressure,serum creatinine,urea nitrogen and urinary albumin of two groups were significantly decreased (P ＜ 0.05).Systolic blood pressure,diastolic blood pressure,serum creatinine,urea nitrogen and urinary albumin in the observation group were significantly lower than that in the control group (P ＜ 0.05).All the pregnant women were followed up until delivery,and the two groups had no maternal and neonatal death cases.The observation group had higher natural delivery rate,and lower fetal distress and pregnancy induced hypertension rate were than the control group (P ＜0.05).Conclusion The acupuncture point massage has positive function on blood pressure control for pregnancy induced hypertension,and it can significantly improve the pregnancy outcomes of pregnant women.

Objective To study the effect of self-management diary on blood glucose control and pregnancy outcomes in pregnant women with gestational diabetes mellitus.Methods The clinical data of 72 pregnant women with gestational diabetes mellitus admitted in our hospital were retrospectively analyzed.According to the different nursing intervention patterns, the patients were divided into control group and observation group.Pregnant women of two groups were given supportive treatment of conventional symptomatic drugs.Pregnant women in the control group were given routine general nursing interventions to guide their healthy dietary in their families, and the pregnant women in observation group were given self-management diary nursing intervention, therapeutic efficacy in blood glucose control compliance rate and pregnancy outcomes were compared.Results The levels fasting blood glucose, Postprandial 2 h blood glucose and glycosylated hemoglobin after intervention in two groups were statistically significant (P<0.05).The control level of blood glucose in observation group was better than the control group(P<0.05).The level of serum C-peptide (fasting serum C-peptide and postprandial 2 h peptide) in the observation group was significantly better than that in the control group (P <0.05).The cesarean section rate and mother-infant health indices of the observation group were significantly better than that in the control group, the differences were statistically significant(P<0.05).Conclusion Nursing intervention model is of great significance to improve the nursing quality of the whole hospital.Implementation of self-intervention model of pregnant women can not only effectively control gestational diabetes mellitus of pregnant women and significantlyreduce rate of cesarean section;so it is worthy of clinical application.

Objective:The effect of intermedin (IMD) on ATP-induced activation of inflammatory bodies and pyroptosis of cells and its mechanism were studied using lipopolysaccharide (LPS)-sensitized mouse macrophage line RAW 264.7.Methods:The cells were divided into the control groups, the LPS groups, LPS+IMD groups, and LPS+IMD+LY294002 groups. The expression of interleukin (IL)-1β and IL-18 and the activation of nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammatory cells were detected by real-time PCR and western blotting, and the pyroptosis of cells was detected by propidium iodide (PI) staining. The measurement data was represented by MS± SD, and the inter-group difference was compared with ANOVA calculations, and P<0.05 represented the difference with statistical significance. Results:Compared with the control group [(0.83±0.09) vs (0.49±0.04)], the ratio of phosphorylated phosphatidylinositol-3-kinase, p-PI3K)/phosphatidylinositol-3-kinase (PI3K) (0.44±0.05) and p-Akt/Akt (0.27±0.06) in the LPS group was significantly decreased. The ratios of p-PI3K/PI3K (1.22±0.18) and pAkt/Akt (0.83±0.09) in LPS+IMD group was significantly increased ( F=31.40, P<0.001; F=50.88, P<0.001). Compared with the control group, the mRNA and protein expressions of IL-1β, IL-18 and NLRP3 inflammasome (NLRP3, caspase-1, ASC) in RAW264.7 cells were up-regulated in the LPS group (LPS and ATP). Compared with LPS group, IMD treatment inhibited the expression of inflammatory cytokines IL-1β, IL-18 and NLRP3 inflammasome, which was blocked by LY294002, a blocker of PI3K/Akt pathway. The results of real-time PCR showed that the relative expression of IL-1β mRNA was (1.00±0.11) in the control group, (8.32±0.61) in the LPS group, (8.32±0.55) in the LPS+IMD group, and (7.23±0.41) in the LPS+IMD+LY group ( F=15.42, P<0.001). The relative expression of IL-18 mRNA in the control group was (1.00±0.17), (1.82±0.21) in the LPS group, (1.14±0.15) in the LPS+IMD group, and (1.53±0.11) in the LPS+IMD+LY group respectively ( F=18.16, P<0.001). The relative expression of NLRP3 mRNA in the control group was (1.00±0.13), (2.58±0.18) in the LPS group, (1.07±0.17) in the LPS+IMD group, and (1.33±0.32) in the LPS+IMD+LY group respectively ( F=15.98, P< 0.001); The relative expression of caspase-1 mRNA in the control group was (1.00±0.09), (6.20±0.19) in the LPS group, (3.43±0.06) in the LPS+IMD group, and (5.50±0.45) in the LPS+IMD+LY group respectively ( F=18.39, P<0.001). The relative expression of ASC mRNA in the control group was (1.00±0.21), (4.58±0.48) in the LPS group, (2.07±0.51) in the LPS+IMD group, and (3.33±0.32) in the LPS+IMD+LY group respectively ( F=15.19, P<0.001). Western blotting results showed that the relative expression of IL-1β protein was as follows: (100%) in the control group, [(188±14)%] in the LPS group, [(112±11)%] in the LPS+IMD group, and [(171±27)%] in the LPS+IMD+LY group respectively ( F=21.25, P<0.001). The relative expression of IL-18 protein in the control group was 100%, [(183±16)%] in the LPS group, [(115±19)%] in the LPS+IMD group, and [(179±23)%] in the LPS+IMD+LY group respectively ( F=19.62, P<0.001). The relative expression of NLRP3 protein was 100% in the control group, [(149±15)%] in the LPS group, [(106±10)%] in the LPS+IMD group, and [(144±15)%] in LPS+IMD+LY group respectively ( F=14.35, P<0.001). The relative expression of ASC protein was 100% in the control group, [(188±12)%] in the LPS group, [(110±18)%] in the LPS+IMD group, and [(192±8)%] in the LPS+IMD+LY group ( F=15.79, P<0.001). Conclusion:IMD inhibits the activation of NLRP3 inflammasome and cell pyroptosis by regulating PI3K/Akt activity.

Objective: To investigate the association of D-dimer (DD) level on admission with the hospital length of stay (LOS) for the children with community-acquired pneumonia (CAP). Methods: The children diagnosed as CAP hospitalized in the Second Hospital of Tianjin Medical University from December 2016 to December 2017 were studied. The clinical and biological variables were retrieved via electronic medical record system. Binary logistic regression model and Cox proportional risk model were constructed to estimate the assosiation of DD level with hospital length of stay(LOS). Results: A total of 413 children met the inclusion criteria. Their median of LOS was 7 days (range from 3 to 21 days). The median of DD level on admission was 510.87 ng/mL and tertiles were 400 ng/mL and 712.23 ng/mL. In logistic regression model, both the high (＞712.23 ng/mL) and middle (400-712.23 ng/mL) DD level groups were in more risk for hospital stay of more than 7 days in comparison with the low DD level group (＜400). The OR values were 3.335 (95%CI:1.973-5.637, P＜0.001) and 2.015 (95%CI:1.195-3.398, P=0.009) respectively. Consistently, in Cox model high level of DD was associated with low probability of discharge (HR=0.652, 95%CI: 0.486-0.874, P=0.004 ), suggesting more risk of prolonged LOS in contrast to the low DD level group. Conclusion The DD level on admission should be independently associated with the hospital length of stay, suggesting the consideration of DD levels may be helpful for clinical management of the hospitalized children with CAP.