This thesis analyzes the current problems in the medical morality and ethics among medical staff,including the insufficiency of service conception,excessive emphasis on personal economic benefits,and the absence of basic morality,and points out the importance of medical morality and ethics construction.Concrete suggestions are also raised from the aspects of strengthening the moral education of serving the people,establishing an overall supervision mechanism,and generally improving medical service quality.

Objective To investigate the preference of the postgraduates in school for work and their psychological changes based on the analysis of the employment status of postgraduates majoring in clinical science of stomatology in Anhui medical university in recent five years in an aim to provide preemployment counseling.Methods The employment status of postgraduates majoring in clinical science of stomatology in affiiated stomatological hospital of Anhui medical university in recent five years (2006 -2010) was summed up.Questionnaire of employment preference and the psychological pressure was conducted in 66 postgraduates majoring in clinical science of stomatology (2008 -2010 grade).Results The employment rate of provincial first-class hospitals was obviously decreased in the recent five years while that of municipal first-class hospitals was increased gradually.The number of postgraduates willing to work in the municipal first-class hospitals was reduced while that willing to future their study and work in the non first-class hospitals was increased.Psychological pressure was univcrsally existed in students and did not get released.Conelusion As the employment situation for postgraduates majoring in clinical science of stomatology changes,the preference for work and psychological pressure of the postgraduates also undergo corresponding changes.Targeted measures can be formulated to work out the problem based on the understanding of these changes.Meanwhile,adjustment should be made in the training methods and employment guidance for postgraduates majoring in clinieal science of stomatology.

OBJECTIVE　To detect the trace glutaraldehyde in the fluid from venous circuit tube of hemodialysis,a HPLC assay was developed.METHODS　20 mL fluid taken from the venous circuit tube were derived with DNPH for 3 h,then filtered and injected. Chromatography was conducted on C18 column at 29℃.The mobile phase was consisted of 60% CH3N and 40% H3PO4 with the flow rate at 1 mL*min-1, and the detetion wavelength was at 365 nm.RESULTS　The concentrations of glutaraldehyde in the fluid ranged from 14.99 to 37.40 μg.mL-1.CONCLUSION　This HPLC method is simple and accurate to detect the trace glutaraldehyde remained in the fluid from venous circuit tube.

Objective To investigate the social relational quality and social avoidance and distress in patients with permanent Cystostomy , and explore the effects of social relational quality on social avoidance and distress.Methods A total of 203 patients with permanent cystostomy were surveyed using the social relational quality scale and the social avoidance and distress scale .The scores of social avoidance and distress were compared among patients with different clinical characteristics , and the hierarchical regression analysis was applied for exploring the effects of social relational quality on social avoidance , distress.Results The total scores of social relational quality and social avoidance and distress in patients with permanent cystostomy were (44.18 ±6.60) and (15.38 ±6.32) respectively.Patients in different genders, ages, marital statuses, occupations, catheterization times and primary diseases had significantly different scores of social avoidance and distress ( P<0.05).The hierarchical regression analysis showed that gender , occupation, time of catheterization, primary disease, family cohesion, family commitment and friendship were independent factors in predicting the social avoidance and distress of patients with permanent cystostomy ( P<0.05 ) .Conclusions The social relational quality of patients with permanent cystostomy is at low level , while the social avoidance and distress is at relatively high level .The social relational quality determines the social avoidance and distress of patients with permanent cystostomy , so improving the social relational quality is promising to avoid the social avoidance and distress of patients with permanent cystostomy .

Receptor-interacting protein kinase 1(RIPK1)is a multi-domain serine/threonine protein kinase that causes downstream signal transduction and biological effects by phosphorylating specific proteins.In recent years,with the in-depth study of RIPK1,scholars have found that it is of great significance in autoimmune diseases,neurodegenerative diseases,and a variety of solid tumors and hematological tumors.On the one hand,RIPK1 promotes cell survival and inflammatory responses by activating specific pathways such as nuclear factor-κB(NF-κB)and mitogen-activated protein kinase(MAPK).On the other hand,RIPKl promotes apoptosis by interacting with cysteinyl aspartate specific proteinase-8(caspase-8),or promotes necroptosis by interacting with RIPK3 and mixed lineage kinase domain-like protein(MLKL).As an upstream signal,RIPK1 has different expression levels in patients with different tumors.Its scaffold function and kinase activity can regulate cancer progression,initiate adaptive immunity,inhibit tumor progression,and generate an immunosuppressive tumor microenvironment to promote tumor development.Its dual role has been demonstrated in regulating the occurrence and development of tumors and the body's immune response,and can be used as a new therapeutic target to control cancer progression.This paper starts with the structure of RIPKI to further explore its function in regulating cancer progression and immune response,and to provide new ideas for the development of cancer-targeted drugs.

Objective To analyze related behaviors of individual preparedness and influencing factors on violent terrorist attacks among undergraduates.Methods A total of 1 800 undergraduates from 5 colleges or universities in Guangzhou were selected,using the stratified cluster method.A questionnaire involving the response to violent terrorist attack behavior was used to assess the individual preparedness behaviors among undergraduates.A self-made questionnaire was applied to collect information on demographic factors,cognitive and preparedness behaviors.Results The mean score of individual preparedness behavior among undergraduates was 13.49 ± 5.02 while information on seeking behavior was 4.27 ± 1.64,avoidance behavior was 5.97± 2.16 and violent terrorist attack response behaviors was 23.73 ± 7.21,with 30.0 percent of undergraduates behaved properly.Significant differences were found in the scores of behaviors on the response to violent terrorist attack with different gender,major they pursue or religious belief (P＜0.05),among undergraduates involved in this study.Results from the logistic regression analysis revealed that persons being girls (OR=1.46,95％ CI:1.06-2.01),with bigger perceived probability (OR=1.60,95％ CI:1.12-2.30),with higher alertness (OR=3.77,95％ CI:2.15-6.61),with stronger coping confidence (OR=0.34,95％ CI:0.24-0.48) and bigger affective response (OR1=3.42,95％ CI:2.40-4.86; OR2 =0.23,95 ％ CI:0.1 3-0.41),would present more prominent behavior responses when facing the violent terrorist attack.Conclusion Individual response behaviors to violent terrorist attacks among undergraduates were relatively ideal.Perceived probability,alertness,coping confidence and affective response appeared to be independent influencing factors related to response behaviors against violent terrorist attack.In colleges and universities,awareness on violent terrorist attacks should be strengthened among undergraduates.Focus should target on psychological education dealing with disaster,knowledge and skills needed for emergency response,so as to respond to the emergency on campus.

Ojective To explore the effect of the hydroxyapatite(HAp)and gelatin(Gel)coating on the healing of the polyethylene terephthalate(PET)artificial ligament.Methods The artificial ligaments were divided into a PET group with a pure PET surface and a PET/HAp/Gel group coated with HAp and Gel.Both coatings were observed using the scanning electron microscope(SEM).Forty-eight male New Zealand rabbits were randomly divided into two groups and underwent anterior cruciate ligament reconstruction,before two kinds of artificial ligaments were implanted respectively.Four weeks and 8 weeks after the operation,the rabbits were sacrificed,and histological hematoxylin and eosin (HE)staining as well as the biomechanical examination were performed.Results HAp/Gel coating was found depositing on the surface of PET artificial ligaments.Histological HE staining showed a thick fibrous connective tissue forming at the graft-host bone interface 4 weeks postoperatively,and the interface width of both groups were narrowed,with significantly more shrinking in the PET/HAp/Gel coating group.And new bone tissues were found in the interface of PET/HAp/Gel group 8 weeks after the operation.The biomechanical examination found significant differences in the failure load between the PET(46.16 ± 2.88 N) and PET/HAp/Gel group(71.32 ± 3.92 N)8 weeks after the surgery(P=0.0021).And 4 weeks and 8 weeks after the surgery,significant differences were found in the stiffness between the PET group and the PET/HAp/Gel group(11.06 ± 1.14 N/mm vs 16.20 ± 1.17 N/mm,P=0.0199;14.37 ± 0.88 N/mm vs 24.35 ± 1.35 N/mm,P=0.0008).Conclusion HAp/Gel coating can enhance the osteogenesis of PET artificial ligaments,promoting the new bone formation at the graft-host bone interface and herein strengthening the graft-host bone healing.

Objective:To evaluate a new type of draw-bar skin stretcher in repair of full-thickness skin defects.Methods:From May 2015 to January 2019, 52 patients with full-thickness skin defects were repaired with a new type of draw-bar skin stretcher at Daping Hospital, Army Medical University. They were 40 males and 12 females, aged from 4 to 61 years (average, 37.1 years). Their skin was stretched for primary wound closure. When primary wound closure failed, skin stretching was performed again to close the wound depending on the wound condition. When the Pinch test was negative after skin stretching, the wound was sutured directly. In cases of positive Pinch test, a skin graft or flap was used to repair the remaining wound. At 12 months after surgery, scar contracture and size of skin graft or flap were observed and wound healing after skin stretching was evaluated in comparison with the original wound.Results:After skin stretching, one-stage wound closure was achieved in 36 cases and multi-stage wound closure in 8 cases; of the remaining 8 cases, 2 were repaired by skin graft and 6 by skin flap after their wounds were reduced by skin stretching. In one-stage closed wounds, infection occurred in 3 cases and marginal necrosis in 5 cases; in the wounds repaired by skin graft or flap, no infection or necrosis was observed. The 12-month follow-up for all the patients showed fine healing of all the wounds after one-stage or multi-stage closure, linear scar, absence of scar contracture, and smaller wound sizes than the original ones after skin graft or flap repair.Conclusions:Skin stretching using our new type of draw-bar skin stretcher is an effective treatment for skin wounds. It can replace traditional skin grafting and flap surgery in some cases, but its indications should be strictly followed to avoid related complications.