Iodinated thyroglobulin (TG) can reflect the storage of thyroid hormones and iodine in the thyroid, which has an important influence on thyroid function. However, the study on iodinated TG and autoimmune thyroiditis has yet to be further conducted. This paper reviews the formation of iodinated TG, the measuring method of TG, and the molecular mechanism of iodinated TG function, including the relationships between iodinated TG and thyroid peroxidase adjustment, the expression of thyrotropin receptor, thyroid transcription factor 1, paired box gene 8, and iodine and sodium transporter, last but not least, we aim to investigate the immune and autophagy mechanisms of high iodinated TG-induced autoimmune thyroiditis.

ObjectiveTo investigate the effect of neuromuscular electrical stimulation (NMES) on quadriceps muscle strength and walking for patients after anterior cruciate ligament reconstruction (ACLR). MethodsThirty-four patients after ACLR were selected at Beijing Rehabilitation Hospital of Capital Medical University from July, 2022 to October, 2023, and randomly divided into control group (n = 17) and experimental group (n = 17). Both groups received routine rehabilitation and functional training, and the experimental group received NMES during the functional training, while the control group received sham NMES, for eight weeks. Quadriceps peak torque-to-weight ratio, single-leg support phase and plantar impulses during walking were measured before and after intervention. ResultsTwo cases in the control group and three in the experimental group dropped down. Quadriceps peak torque-to-weight ratio improved in both groups after intervention (|t| > 17.578, P < 0.001), and improved more in the experimental group than in the control group (t = 4.714, P < 0.001); while the affected single-leg support phase and the affected/unaffected single-leg support phase ratio improved in both groups (|t| > 16.882, P < 0.001), and improved more in the experimental group than in the control group (t > 3.234, P < 0.01); and plantar impulses of all zones optimized in both groups (t > 9.221, P < 0.001), and were better in the experimental group than in the control group(|t| > 2.852, P < 0.01). ConclusionNMES may further improve quadriceps muscle strength, plantar pressure distribution during walking and single-leg support in patients after ACLR.