2.The role of primary cilium in signal transduction and its mechanism.
Wen-gui SHI ; Xiao-ni MA ; Ke-ming CHEN
Journal of Zhejiang University. Medical sciences 2014;43(3):359-365
The primary cilium is a solitary and special organelle that emanates from the cell surface of most mammalian cells, which is anchored to the cell by mother centriole during the interphase and G0 of cell cycle. Recent studies have revealed that the primary cilium is a sensory organelle to receive extracellular signals and plays a key role in the signal transduction and pathogenesis of diseases. This review presents the structure and the forming process of the primary cilium during cell cycle. The signal transductions associated with primary cilium, including platelet-derived growth factor receptor αα, hedgehog, Wnt are discussed and the relevant researches in the future are proposed.
Cilia
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physiology
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Humans
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Signal Transduction
;
physiology
3.Effect of temperature on the pineal gland cell in rats.
Xifang LIU ; Xin NIU ; Qianjin FENG ; Yaming LIU
Chinese Medical Journal 2014;127(17):3134-3134
4.Research advances in the expression of co-stimulatory molecules and signaling pathways in γδT cells.
Acta Academiae Medicinae Sinicae 2014;36(2):223-226
Human T lymphocytes are divided into αβT cells and γδT cells on the basis of the different expressions of T cell receptors. In recent years, the studies of the regulation of T cell activation and tolerance by co-stimulatory molecules and their signaling pathways in αβT cell have made remarkable progress; however, relatively fewer investigations have been performed on γδT cells. A clearer understanding of the roles of co-stimulatory molecules and their signaling pathways in the positive/negative regulation of γδT cells at different stages will provides new insights for the treatment of viral infections, cancer, autoimmune diseases, transplant rejection, and other conditions.
Humans
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Lymphocyte Activation
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physiology
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Signal Transduction
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T-Lymphocyte Subsets
;
physiology
5.Research advances on adrenergic receptor signaling involved in disease microenvironment through regulation of macrophages.
Ji-Ju WANG ; Da-Jin LI ; Mei-Rong DU
Acta Physiologica Sinica 2020;72(2):227-234
Adrenergic receptor (AR), one of the key receptors for nervous system, plays an important role in the immune microenvironment and the progression of many diseases. In recent years, the regulation of ARs and its signal on macrophages has become a research hotspot. Researchers found that ARs could exert different regulatory functions on macrophages in different microenvironments, which in turn affects occurrence and development of diseases such as tumor, heart failure, obesity, acute injury, infection and pregnancy-related diseases. This review summarizes the expression and functional regulation of ARs on macrophages, and the role of ARs in microenvironment of related diseases, which might provide new ideas for the treatments.
Disease
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Humans
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Macrophages
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physiology
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Receptors, Adrenergic
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physiology
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Signal Transduction
6.TGF-beta signaling during hematopoietic development--review.
Journal of Experimental Hematology 2006;14(6):1253-1257
Hematopoietic development is characterized by the dynamic generation of hematopoietic stem/progenitor cells during embryogenesis, and afterward, the maintaining of hematopoietic homeostasis in adult. Mouse model has been appreciated valuable for dissecting the regulatory mechanisms of hematopoietic development. As an important cytokine playing pivotal and versatile roles in the regulation of hematopoiesis, transforming growth factor-beta (TGF-beta) attracts more and more attention. In particular, gene targeting by homologous recombination provides a key means for systematic evaluation of how TGF-beta signaling is involved in hematopoiesis under physiological conditions. To further illustrate the functions and possible mechanisms of TGF-beta in hematopoietic development, hematopoietic phenotypes of targeted mutations and/or dominant negative transgenes of molecules within the TGF-beta signaling pathway are categorized and discussed in this review.
Animals
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Hematopoiesis
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physiology
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Hematopoietic Stem Cells
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physiology
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Humans
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Signal Transduction
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physiology
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Transforming Growth Factor beta
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physiology
7.The physiological meaning of rapid responses to steroid hormones in epithelia.
Journal of Korean Medical Science 2000;15(Suppl):S57-S58
No abstract available.
Aldosterone/physiology*
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Animal
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Epithelial Cells/physiology*
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Estradiol/physiology*
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Signal Transduction/physiology*
8.Progress on Hedgehog signaling transduction.
Acta Physiologica Sinica 2014;66(4):415-422
Hedgehog (Hh) signaling pathway plays an important role during embryonic development and pattern formation. Disruption of Hh pathway results in various developmental disorders and increasing cancer incidence. Here we provide a comprehensive review of the pathway members, focusing on how mammalian Hh regulates the Gli family of transcription factors through its downstream members, the so-called "canonical signaling pathway". Hh signaling pathway is highly conserved among species, and primary cilia plays an important role as a "signaling center" during vertebrate signal transduction. Further, in the past few years, numerous studies have shown that Hh signal can also be transduced through Gli-independent ways collectively referred to as "non-canonical signaling pathways", which can be subdivided into two modules: (i) those not requiring Smo and (ii) those downstream of Smo that do not require Gli transcription factors. Thus, we review the rapid progress on canonical and non-canonical Hh pathways.
Animals
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Cilia
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physiology
;
Hedgehog Proteins
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physiology
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Receptors, G-Protein-Coupled
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physiology
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Signal Transduction
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Transcription Factors
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physiology
9.Nutritional and signal interactions in a tumor-host social relationship.
Mei-qing LOU ; Qiang HUANG ; Yao-dong ZHAO
Chinese Medical Journal 2011;124(15):2400-2400
Animals
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Humans
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Neoplasms
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metabolism
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pathology
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Signal Transduction
;
physiology
10.Essence of resistance to anti-angiogenic therapy in tumors.
Chinese Medical Journal 2011;124(24):4363-4363
Animals
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Humans
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Neoplasms
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metabolism
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pathology
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Signal Transduction
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physiology