1.Study of susceptibility loci located within Xp11 in attention deficit hyperactivity disorder
Sanduo JIANG ; Rene XIN ; Yiping QIAN ; Sicui LIN ; Fei LI ; Xiaodong WU ; Dongxiang WANG ; Guomei TANG ; Kaida JIANG
Chinese Journal of Medical Genetics 2001;18(3):169-172
Objective To detect the genetic relationship between monoamine oxidase(MAO) A type gene and attention deficit hyperactivity disorder(ADHD) in Chinese. Methods The haplotype-based haplotype relative risk(HHRR) and the transmission disequilibrium test(TDT) methods were used to analyze the genetic association and linkage in 60 ADHD children and their parents. Results In this sample were found significant association (χ2=4.90, P<0.05) and linkage (χ2=4.84, P<0.05) between the MAOCA 114bp allele and DSM-III-R-diagnosed ADHD in trios composed of father, mother and affected offspring. Conclusion The above results suggested that ADHD was associated and in linkage with MAO A gene, and the susceptibility loci might reside in chromosome Xp11 for ADHD.
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