OBJECTIVET To explore the relationship between the expression of SOX4 gene and early recurrence of hepatocellular carcinoma (HCC) after curative resection.

METHODSSOX4 expression was detected immunohistochemically in 60 HCC patients including 30 with and 30 without early recurrence after curative resection, with 30 normal liver specimens as the control.

RESULTSThe expression of SOX4 was significantly higher in HCC than in normal liver (41.7% vs 16.7%, P<0.05), and in HCC tissues, the expression was significantly higher in early recurrent HCC after curative resection than in HCC without early recurrence (56.7% vs 26.7%, P<0.05). SOX4 expression was inversely correlated to the patients' gender, age, tumor size, HBsAg, and Edmonson grade (P<0.05).

CONCLUSIONSOX4 is closely associated with early recurrence of HCC after curative resection, and its overexpression may contribute to early recurrence of HCC. SOX4 may serve as a new molecular indicator for evaluating the prognosis of HCC.

Adult ; Aged ; Biomarkers, Tumor ; Carcinoma, Hepatocellular ; genetics ; metabolism ; surgery ; Female ; Humans ; Liver Neoplasms ; genetics ; metabolism ; surgery ; Male ; Middle Aged ; Neoplasm Recurrence, Local ; genetics ; Prognosis ; SOXC Transcription Factors ; genetics ; metabolism

Objective:To sort out the current situation of rehabilitation assistive devices rental service in China, and suggest the policy for its development. Methods:Based on the four-dimensional social security policy analysis framework, with the combination of subject retrieval and field research, the market players, supporting systems, rental products, financial security and professionals in some pilot areas of community rental of assistive devices in China were summarized. Results:There were still some problems in the rental service of assistive devices in China, mainly as insufficience of main players of the rental market, supporting policies and systems, payment security system, professionals, and social recognition, etc. Conclusion:It is important to reasonably set up rental products, standardize service enterprises, cultivate market players, increase investment, promote talent training, and strengthen publicity, to promote the development of the rental of assistive devices.

Autophagic flux refers to a series of dynamic process of autophagic bilayer membrane formation, autophagosome formation, autophagolysosomes formation and degradation. The etiology of cataract is complex, including congenital abnormalities in lens development due to genetic mutations, oxidative damage due to aging, abnormalities in glucose metabolism due to diabetes, and proliferation of lens epithelial cells(LECs)stimulated by postoperative inflammatory factor, all of which are associated with the development of cataracts. A growing number of research in recent years have discovered that altering the status of LECs can contribute to the pathophysiological process of cataract by regulating autophagic flux. This review summarized the impacts of autophagic flux regulation on cataract.