S.I. of TCSA PCH (group B) and musk ambrette PCH (group D) were respectively g3 49% and 75.00 S.I. of group A and B, which were only challenged with TCSA and musk ambrette respectively without prior sensitization, were 33, 33% and 27. 78%. These data indicated the TCSA PCH (group B) was experimentally produced in guinea pigs when it compared to musk ambrette PCH (group D) and controls (group A and C) (Table 1). However, S.I. of TCSA PCH was somewhat lower than index of musk ambrette PCH.
Animals ; Guinea Pigs* ; Guinea* ; Hypersensitivity*

Subperiosteal Ganglion is a rare cystic lession, although ganglions are frequently found in close proximities to joints and tendon sheaths. It is characterized by a thin-walled cyst containing tenacious mucoid fluid and by the pedicle attached to periosteum. This report describes a middle-aged man with a subperiosteal ganglion which occured beneath the periosteam of the tibia. Presenting symptoms were pain and circumscribed swelling over the anteromedial aspect of the right proximal tibia.
Ganglion Cysts ; Joints ; Periosteum ; Tendons ; Tibia

20-year-old patient presented with the episodes of generalized hyperkeratotic lesions with bullae since her early life, without family history. Histopathological examination by light and electron microscopes showed the characteristic features of epidermolytic hyperkeratosis. Primarily, she failed to respond to the treatment with propylene glycol. Vitamine A palmitate(A-Mulsin) per os appears to be a beneficial remedy for epidermolytic hyperkeratosis, although its availability is limited due to the side effects on a long term therapy. Repeated biopsies in the normal appearing lesions 2 months after treatment of vitarnin .A palmitate showed a substantial reduction of the horny layer on the light microscope and orderly arrangement of the tonofilaments, and properly formed keratohyaline granules on EM, but the underlying disorder of keratinization remained unchanged. Treattnent of 2 months with vitamin A was interrupted by side effects of nasal bleealing, chelitis and xerosis.
Biopsy ; Humans ; Hyperkeratosis, Epidermolytic* ; Intermediate Filaments ; Propylene Glycol ; Vitamin A* ; Vitamins* ; Young Adult

No abstract available.
Lichens*

BACKGROUND: Left atrial thrombus(LAT) has long been recognized as a complication of mitral stenosis(MS).The transesophageal echocardiographic approach readily visualize LAT. We evaluated the risk factors for left atrial thrombus in patients with MS using transthoracic(TTE) and transesophageal echocardiography(TEE). METHODS AND RESULTS: One hundred and forty-three(patients) who had moderate to severe MS were consecutively studied with TTE and TEE. They were 43 males(30%) and 100 females(70%).The mean age was 44+/-11 years(range 21-70). Twenty-five patients had at least one episode of embolic events. Ninety-six patients were in atrial fibrillation(AF). LAT was detected in 30 pts(21%) : 16 had thrombus confined to the LA appenge(LAA), 14 to true LA cavity and/or LAA. TTE variables were compared between LAT group and non-LAT group. Univariate predictors of LAT were mitral valve area(MVA)(0.78+/-0.22cm2 vs 1.05+/-0.32cm2, p=0.001), pressure half time(353+/-88ms vs 258+/-118ms, p=0.002). LV ejection fraction(EF)(55+/-11% vs 62+/-8%,p=0.008), LA size (58+/-11mm vs 52+/-7mm, p=0.033) and AF(p=0.001). Stepwise logistic regression analysis revealed significant independent predictors of LAT to be AF(p=0.02), MVA(p=0.02) and EF(p=0.03). CONCLUSION: Left atrial thrombus was not uncommon in patients with rheumatic mitral stenosis. Small mitral valve area and reduced ejection fraction of left ventricle appear to be significant predictors of LAT in mitral stenosis with atrial fibrillation.
Atrial Fibrillation ; Echocardiography* ; Heart Ventricles ; Humans ; Logistic Models ; Mitral Valve ; Mitral Valve Stenosis* ; Risk Factors ; Thrombosis*

No abstract available.
Ivermectin ; Larva Migrans

Endoscopic injection therapy using various different agents(ethanol, polidocanol, epinephrine with and without hypertonic saline, etc.) is considered as the least expensive and effective technique to obtain hemostasis in peptic ulcer bleeding, however most of these agents induce tissue necrosis or degeneration. Theoretically the injection of fibrin glue in peptic ulcer bleeding may be safer than that of other agents, however, to date, there have been no data from randomized clinical trials on the comparison of the efficacies between these agents. To compare the hemostatic efficacy between FG[Beriplast P, Behring, Germany] and HSE[3% saline and epinephrine(1: 10,000)], we conducted a prospective, randomized, clinical trial among one hundred twenty-seven patients with peptic ulcer bleeding from March, 1992 to December, 1993 and in whom a visible vessel or active bleeding was identified.
Epinephrine* ; Fibrin Tissue Adhesive* ; Fibrin* ; Hemorrhage* ; Hemostasis ; Humans ; Necrosis ; Peptic Ulcer* ; Prospective Studies*

Aortic dissection is a medical emergency requiring prompt diagnosis and maybe emergency surgery especially if the ascending aorta is involved. We have performed transesophageal echocardiography(TEE) in 22 consecutive patients with suspected aortic dissection. The diagnosis was subsequently proven in 14 patients(9 males, 2 females, mean age 51+/-11years) on the basis of TEE. The results and effectiveness were compared with computed tomography (CT) and aortography. Seven patients had type I aortic dissection, three had type II and four had type III. Twelve patients had hypertension. There was aortic regurgitation in five of seven patients with type I dissection and in all three patients with type II dissection. Type I dissection was found by TEE in seven patients who had intimal flap showing parallel movement to the aortic wall. CT was positive in only three of five of these patients. Type II dissection was seen in three patients by TEE. CT demonstrated dissection in one of three of these patients. In one patient the false lumen was filled with a thrombus, which was negative at angiography. Type III dissection was found by TEE in four patients. CT was positive in two of four patients. Aortography was performed and positive in one patient. The starting point of aortic dissection could be demonstrated in all four patients by TEE. TEE was well tolerated by patients with aortic dissection and associated with no major complications. In conclusion. TEE was very useful in detecting aortic dissection and in providing a dynamic information of the intimal flap and of the presence and extent of luminal thrombus with flow dynamics.
Angiography ; Aorta ; Aortic Valve Insufficiency ; Aortography ; Diagnosis ; Echocardiography, Transesophageal* ; Emergencies ; Female ; Humans ; Hypertension ; Male ; Phenobarbital ; Thrombosis

PURPOSE: To demonstrate the existence in human umbilical cord blood (hUCB) of circulating mesenchymal stem/progenitor cells(MSPC), the adherent cells developed in cultures from hUCB were characterized and induced to differentiate into osteoblasts. MATERIALS AND METHODS: Fifty hUCB harvests were cultured in the media supplemented with 10% fetal bovine serum. Homogeneously adherent fibroblast-like cells obtained during successive subcultivation were characterized by immunophenotyping analysis and induced to differentiate into osteoblasts. Reverse transcription-polymerase chain reaction of osteogenic markers, alkaline phosphatase (ALP) stain, and von Kossa stain were performed. RESULTS: The adherent fibroblast-like cells developed in cultures from hUCB positively expressed the MSPCrelated antigens, but, did not express the hematopoietic, HLA-DR, osteoclast, or endothelial antigens. These cells were well proliferated during successive subcultivation. Under osteogenic condition, these cells showed increased levels of osteogenic mRNAs and strong positivity in ALP and von Kossa stains at 4th week. CONCLUSION: The homogeneous fibroblast-like cells developed in cultures from hUCB were considered to be MSPC. Morphological and immunophenotypical characteristics of these cells were very similar to those of bone marrow-derived MSPC, and well differentiated into osteoblasts.
Alkaline Phosphatase ; Coloring Agents ; Fetal Blood* ; HLA-DR Antigens ; Humans* ; Immunophenotyping ; Osteoblasts ; Osteoclasts ; RNA, Messenger ; Umbilical Cord*

Solitary fibrous tumors (SFT) are rare spindle-cell neoplasms that are found principally in the pleura, and extrathoracic SFTs are even less common. We report here on a case of malignant solitary fibrous tumor in the perianal region. A 47-year-old man was referred to our hospital for surgical treatment of an incidentally discovered perianal mass. Pelvic MRI showed a slightly lobulated solid mass with central necrosis in the ischiorectal fossa. We performed complete removal of tumor with using a postanal approach. The resected specimen was 6.5x5.0x5.0 cm in size, and it was an elastic solid tumor with invasion to the surrounding muscle structures. Histologically, the tumor was composed of a patternless proliferation of spindle cells with a collagenous matrix and the tumor cells showed increased cellularity, cellular pleomorphism and frequent mitotic figure. Immunohistochemical staining was positive for CD34 and negative for desmin, which indicated malignant SFT. We report here on a rare case of malignant SFT in the perianal region along with a review of the literature.
Collagen ; Desmin ; Humans ; Magnetic Resonance Imaging ; Middle Aged ; Necrosis ; Pleura ; Solitary Fibrous Tumors*