Objective To investigate the effects of chronic inflammation, induced by LPS on the development of rat aorta atherosclerosis. Methods Eighty healthy male Wistar rats were divided into 4 groups, normal control, the endotoxin group, homofat-breeded group and endotoxin-homofat-breeded group. HE staining was used to detect the change of rat aorta endomembrane and immunohistochemistry was used to detect the change of expression of TLR4 in rat aorta endothelial cell. Results The AS animal model was constructed successfully and the expression of TLR4 was at a higher level in endotoxin-homofat-breeded group than that in other groups. Conclusion Chronic inflammation has an actively effect during the development of rat aorta atherosclerosis.

Objective To study the causes of bleeding and death of upper digestive tract hemorrhage in old people.Methods Clinical datas of 302 patients with upper digestive tract hemorrhage in senile group were analysed retrospectively,compared with those of 463 patients in non-senile group at the same period.Results The major causes of upper digestive tract hemorrhage in old people were gastric ulcer(96 cases,31.8%),duodenal ulcer(70 cases,23.2%),carcinoma of stomach(30 cases,9.9%).While duodenal ulcer(248 cases,53.6%) was the leading cause in non-senile group.In senile group,23 of 162 patients(mortality 14.2%) with accompanying disease died,while 4 of 140 patients without other disease died(mortality 2.9%).Obvious difference existed between the two groups(P

Objective To study the therapeutic effect of the thrombus suction and direct percutaneous coronary intervention (PCI) for elderly patients with acute ST segment elevation myocardial infarction (STE‐MI) .Methods A total of 124 elderly pa‐tients with acute STE‐MI in our hospital from September 2012 to September 2014 were collected and divided into two groups(under the agreement of patients and family members) ,the experimental group (56 cases) was treated with thrombus suction and direct PCI ,while the control group (68 cases) was only treated with PCI treatment ;the postoperative immediate TIMI flow of coronary artery ,postoperative corrected TIMI frame count (CTFC) ,levels of myoglobin ,cTnT and CK‐MB ,percentage of ST elevation back over 50% ,postoperative 6-month follow‐up situation were observed in the two groups .Results The percentage of postoperative ST segment elevation drop>50% at postoperative 1 h in the experimental group was significantly higher than that in the control group (P<0 .05);the levels of myoglobin ,cTnT and CK‐MB ,postoperative corrected CTFC frames and rate of no reflow in the ex‐perimental group were significantly lower than those in the control group (P<0 .05);during postoperative 6 -month follow up , there were no statistically significant differences in major adverse cardiac events (such as angina pectoris ,myocardial infarction ,re‐vascularization ,etc) between the two groups(P>0 .05);the percentage of LVEF>50% in the experimental group was significantly higher than that in the control group(P<0 .05) ,moreover the percentage of LVEF>50% in the two groups had statistical differ‐ence between before and after operation(P<0 .05) .Conclusion Clinical curative effect of thrombus suction and direct PCI for eld‐erly patients with acute STE‐MI is superior to simple direct PCI treatment .

The adhesion of cells to each other and to the proteins of the extracellular matrix provides a stable environment for cell growth, differentiation and migration. This is a prerequisite for the normal function of the cardiovascular system. Thus the abnormal adhesion function may play a key role in the pathogenesis and development of cardiovascular diseases. To date, there are six main groups of adhesion molecule, and integrins family are the largest and most broadly distributed of the families of cellular adhesion receptors. They have an important role in several aspects of cardiovascular diseases and that its regulated inhibition leads to a reduction in incidence and mortality due to these disorders. This review focuses upon the structure、mechanism and their roles in cardiovascular diseases which maybe facilitate the development of novel therapies.

0.01). There was a significant difference in TIMP-1,-2 expressions between saccule injury group and control group (P

Objective To investigate the clinic and microbial characteristic of fever along with agranulocy-tosis in patients with malignant hematopathy. Methods Retrospective study was carried out on patients with malig-nant hematopathy who developed agranulocytosis during hospitalization. Results A total of 512 febrile events occurred. Duration of agranulocytosis,severe agranulocytosis,poor physical condition,previous exposure to broad-spectium antibiotics and central venous catheterization were correlated with higher incidence of febrile event. There are 328 cases(64.06%)with definite infected sites and 184 cases(35.94%)with fever of unknown origin(FUO). Gram-negative bacterium was most common(64.35%),followed by Gram-positive bacterium(23.61%)and fungus (12.04%). 57 cases resistant bacteria were detected. Mortality incidence resulting from pulmonary infection was higher than that from FUO(P < 0.005). No significance was found between pulmonary infection and blood stream infection(P>0.25)or between blood stream infection and FUO(P>0.1). Conclusions Many factors were corre-lated with incidence of fever along with agranulocytosis in patients with malignant hematopathy. Gram-negative bacte-rium was most common pathogenic microorganism,followed by Gram-positive bacterium,all of which manifested high drug resistance rate. Understanding the epidemiological trend will be beneficial for clinic treatment.

The article sort out the main planting information of Chinese medicinal materials in Tanchang county from 2012 to 2014, through doing a questionnaire survey, setting technical training and communicating with people who plant, process, and sell the Chinese medicinal materials in the main producing area in 25 villages and towns of Tanchang county. By analyzing the results, the author pointed out the current situation of Chinese medicinal material planting, processing, trading and also the existing problems, and gave a proposal and strategy to the industrial development of Chinese medicinal materials, therefore, set an example to the development of the county territory.
China ; Data Collection ; Drugs, Chinese Herbal ; Plants, Medicinal ; growth & development

Through the analysis of bioethics in the cultural context of China and west,the article elaborated the important influence of culture on bioethics and analysed the debate on bioethics in the present globalization from the angle of culture to make the reasonable choice in the globalization.

Gout is a metabolic inflammatory disease characterized by hyperuricemia. When serum uric acid concentration(sUA) is greater than 420 μmol/L, monosodium urate(MSU) crystals are formed and deposited in joints and connective tissues, resulting in acute gout arthritis. In addition to the concentration of urate, pH is also one of the factors affecting MSU deposition. Lowering pH can promote MSU crystallization. Urine alkalization can raise the pH to 6.2~6.9, which can increase the solubility of urate to prevent MSU deposition and the formation of uric acid stones. Commonly used clinical medications include citrate, bicarbonate, acetazolamide, tromethamine, etc. Among them, potassium citrate is the most commonly used alkali agent in clinical practice. However, due to adverse drug reactions, clinical medications need to be cautious. In addition to pharmacotherapy, dietary intervention has also become an important means of alkalizing urine. When sufficient attention is paid to the construction of a balanced diet, dietary intervention will become a safe and economical method for the treatment of gout, but the long-term efficacy has not been determined. This article discusses the advantages and disadvantages of urine alkalinization in the application of hyperuricemia and gout from aspects of pharmacological treatment and diet management, and provides a basis for proper medication use.

We used WEHI clone—13 cell line as target and MTT colorimetric technique to evaluate monocyte cytotoxicity, this method is superior to the traditional~(51) Cr release technique. It is more sensitive,more rapid and less effectors needed, as well as no isotope contamination, and it is mose suitable in clinic.