No abstract available.
Humans ; Peripheral Nervous System Diseases* ; Pneumoconiosis*

PURPOSE: In the present study, an unusual case of traumatic retinopathy presenting as acute macular neuroretinopathy was reported. CASE SUMMARY: A 69-year-old male was involved in a car accident and experienced a left 5th rib fracture. There was no direct ocular trauma. However, after the accident he noticed paracentral scotoma and loss of vision in his left eye. At initial examination 4 days after the trauma, central visual acuity was hand motion and visual field test revealed central scotoma in the left eye. Spectral domain optical coherence tomography showed hyper-reflectivity of the outer nuclear layer and disruption of the ellipsoid zone. Fluorescein angiography did not show any leakage or vascular damage but near-infrared autofluorescence imaging showed a dark lesion in the macular area. Visual acuity was improved to 0.2 at 2 weeks after trauma and 0.6 at 6 months after trauma while mild ellipsoid zone defect and visual field defect persisted. CONCLUSIONS: Traumatic retinopathy presenting as acute macular neuroretinopathy is an uncommon disease causing paracentral scotomas after non-ocular trauma, and to the best of our knowledge, this is the first reported case in Korea.
Aged ; Fluorescein Angiography ; Hand ; Humans ; Korea ; Male ; Optical Imaging ; Rib Fractures ; Scotoma ; Tomography, Optical Coherence ; Visual Acuity ; Visual Field Tests ; Visual Fields

Bladder dysfunction is a common occurrence following radical hysterectomy. It is a direct consequence of the intraoperative disruption of the autonomic nerve supply to the bladder. We herein evaluated 158 patients who underwent radical hysterectomy for carcinoma of cervix in the Dept. of Obstet.-Gynecol., Seoul National University Hospital into two separate part. In Part 1,140 patients who received the surgery from Jan. 1980 to Dec 1981 were subjected to this study. The records and the follow-up results were analysed retrospectively. Immediate postoperatively, 44.7% of patients presented bladder dysfunction such as large residual urine over 100 cc and delayed perception of bladder filling sensation. In 6 month follow-up group, 15.8% of patients complained urologic symptoms such as strain. stress incontinence, urgency and sensory loss. In 1 year follow-up group, the same symptoms were persisted in 11.5% of patients. In Part 2, urodynamic test was performed in 10 patients preoperatively and 18 patients postoperatively. No differences were found between two groups except marked increase of bladder volume at the first voiding sensation. Urecholine denervation test of Lapides was done in 18 patients postoperatively and three patients revealed positive test, which means partial parasympathetic detrusor denervation. To decrease the incidence of bladder dysfunction, the use of suprapubic cystostomy, subcutaneous injection of urecholine, intermittent self catheterization are recommended rather than indwelling urethral catheter. Urodynamic test is necessary to define the nature and to manage the patients with bladder dysfunction after radical hysterectomy.
Autonomic Pathways ; Bethanechol Compounds ; Catheterization ; Catheters ; Cervix Uteri ; Cystostomy ; Denervation ; Female ; Follow-Up Studies ; Humans ; Hysterectomy* ; Incidence ; Injections, Subcutaneous ; Retrospective Studies ; Sensation ; Seoul ; Urinary Bladder* ; Urinary Catheters ; Urodynamics

Bladder dysfunction is a common occurrence following radical hysterectomy. It is a direct consequence of the intraoperative disruption of the autonomic nerve supply to the bladder. We herein evaluated 158 patients who underwent radical hysterectomy for carcinoma of cervix in the Dept. of Obstet.-Gynecol., Seoul National University Hospital into two separate part. In Part 1,140 patients who received the surgery from Jan. 1980 to Dec 1981 were subjected to this study. The records and the follow-up results were analysed retrospectively. Immediate postoperatively, 44.7% of patients presented bladder dysfunction such as large residual urine over 100 cc and delayed perception of bladder filling sensation. In 6 month follow-up group, 15.8% of patients complained urologic symptoms such as strain. stress incontinence, urgency and sensory loss. In 1 year follow-up group, the same symptoms were persisted in 11.5% of patients. In Part 2, urodynamic test was performed in 10 patients preoperatively and 18 patients postoperatively. No differences were found between two groups except marked increase of bladder volume at the first voiding sensation. Urecholine denervation test of Lapides was done in 18 patients postoperatively and three patients revealed positive test, which means partial parasympathetic detrusor denervation. To decrease the incidence of bladder dysfunction, the use of suprapubic cystostomy, subcutaneous injection of urecholine, intermittent self catheterization are recommended rather than indwelling urethral catheter. Urodynamic test is necessary to define the nature and to manage the patients with bladder dysfunction after radical hysterectomy.
Autonomic Pathways ; Bethanechol Compounds ; Catheterization ; Catheters ; Cervix Uteri ; Cystostomy ; Denervation ; Female ; Follow-Up Studies ; Humans ; Hysterectomy* ; Incidence ; Injections, Subcutaneous ; Retrospective Studies ; Sensation ; Seoul ; Urinary Bladder* ; Urinary Catheters ; Urodynamics

PURPOSE: This study was conducted to examine the factors associated with meaning in life among elderly female community dwellers aged 65 or older who were living alone. METHODS: A quota sample of 222 elderly female living alone was recruited. Data were analyzed with descriptive statistics, independent t-test, one-way ANOVA, Welch's test, Pearson's correlation, and multiple regression using the SPSS 22.0 program. RESULTS: The factors associated with meaning in life included age, education level, perceived economic status, perceived health status, social support, and loneliness. This regression model explained 66% of the variance in meaning in life. CONCLUSION: Based on the results, comprehensive nursing intervention programs for enhancing meaning in life are required.
Aged* ; Education ; Female* ; Humans ; Loneliness ; Nursing

PURPOSE: To compare the fluorescein angiographic findings of nonarteritic anterior ischemic optic neuropathy (NA-AION) and optic neuritis. METHODS: The present study included 41 patients (41 eyes), who were diagnosed with NA-AION or optic neuritis and underwent fluorescein angiography in our clinic. The clinical profiles of patients, characteristics of optic disc head and hemorrhage, and visual field findings were analyzed retrospectively. The onset and filling time, perfusion time of retinal artery, optic disc, and peripapillary choroid were evaluated quantitatively. RESULTS: Patients with NA-AION showed statistically significant delay in both the onset time, filling time and perfusion time of the optic disc and peripapillary choroid compared with patients with optic neuritis (p < 0.05). There was no significant difference in the dye leakage of the peripapillary areas between the 2 groups (p = 0.324). CONCLUSIONS: In the present study, the results of fluorescein filling were significantly different between the NA-AION group and the optic neuritis group. The results may help determine the therapeutic plan and to differentiate between the 2 disease entities, especially in cases of overlapping clinical features.
Choroid ; Fluorescein ; Fluorescein Angiography ; Head ; Hemorrhage ; Humans ; Optic Neuritis ; Optic Neuropathy, Ischemic ; Perfusion ; Retinal Artery ; Retrospective Studies ; Visual Fields

No abstract available.
Cleidocranial Dysplasia* ; Leukemia*

The extract from Smilax china root has been used as medicinal remedy and reported to retain antimicrobial and antimutagenic acitivities. In this study, a possible presence of antioxidant activity of Smilax china root extract was investigated. Methanol extract (Me) revealed the presence of high 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity (IC50 7.4 microg/ml) and protective property of cell's viability. Further fractionation with various solvent extraction and assay showed high levels of DPPH free radical scavenging activity in the ethyl acetate, butanol and water extracted fractions. In addition, V79-4 cells treated with Me of Smilax china root induced an increase of superoxide dismutase, catalase and glutathione peroxidase activities in a dose-dependent manner between 4-100 microg/ml. These results suggest that the medicinal component of the root of Smilax china extracts also contains antioxidant activity.
Animal ; Antioxidants/*pharmacology ; Catalase/drug effects/metabolism ; Cell Line ; Cell Survival ; Dose-Response Relationship, Drug ; Fibroblasts/drug effects/metabolism ; Free Radical Scavengers/chemistry/isolation & purification/*pharmacology ; Free Radicals/metabolism ; Glutathione Peroxidase/drug effects/metabolism ; Hamsters ; Lipid Peroxidation/drug effects ; Lung/cytology ; Plant Extracts/chemistry/*pharmacology ; Plant Roots/*chemistry ; Plants, Medicinal ; Superoxide Dismutase/drug effects/metabolism

The extract from Smilax china root has been used as medicinal remedy and reported to retain antimicrobial and antimutagenic acitivities. In this study, a possible presence of antioxidant activity of Smilax china root extract was investigated. Methanol extract (Me) revealed the presence of high 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity (IC50 7.4 microg/ml) and protective property of cell's viability. Further fractionation with various solvent extraction and assay showed high levels of DPPH free radical scavenging activity in the ethyl acetate, butanol and water extracted fractions. In addition, V79-4 cells treated with Me of Smilax china root induced an increase of superoxide dismutase, catalase and glutathione peroxidase activities in a dose-dependent manner between 4-100 microg/ml. These results suggest that the medicinal component of the root of Smilax china extracts also contains antioxidant activity.
Animal ; Antioxidants/*pharmacology ; Catalase/drug effects/metabolism ; Cell Line ; Cell Survival ; Dose-Response Relationship, Drug ; Fibroblasts/drug effects/metabolism ; Free Radical Scavengers/chemistry/isolation & purification/*pharmacology ; Free Radicals/metabolism ; Glutathione Peroxidase/drug effects/metabolism ; Hamsters ; Lipid Peroxidation/drug effects ; Lung/cytology ; Plant Extracts/chemistry/*pharmacology ; Plant Roots/*chemistry ; Plants, Medicinal ; Superoxide Dismutase/drug effects/metabolism

Mammography is the standard screening method for breast cancer, proven to reduce mortality. However, its diagnostic performance varies depending on patient characteristics and radiologist expertise. Dense breast tissue, present in approximately 70% of Korean women aged 40 to 59, limits detection by obscuring malignancies. Additionally, optimal interpretation requires extensive training, which is not always achievable. Artificial intelligence-based computer-aided diagnosis (AI-CAD) has emerged as a promising tool for enhancing mammographic accuracy and efficiency.Current Concepts: AI-CAD has shown diagnostic performance comparable to that of experienced radiologists while addressing the limitations of traditional CAD systems, particularly excessive false positives. Studies suggest AI-CAD improves radiologists' accuracy, particularly among those with limited breast imaging experience. In Europe, AI-assisted reading is increasingly recognized as a viable alternative to traditional double reading. In Korea, adoption of AI-CAD is expanding, with systems approved by the Korean Food and Drug Administration currently in clinical use. Recently, one AI-CAD system received conditional non-reimbursement designation, allowing hospitals to use it for up to 5 years while collecting clinical evidence to support future insurance coverage decisions.Discussion and Conclusion: AI-CAD has significant potential to enhance early breast cancer detection while maintaining acceptable false-positive rates, making it a valuable adjunct in screening programs. Beyond improved detection, AI-CAD may optimize workflow efficiency by triaging cases and prioritizing high-risk examinations. However, its integration into clinical practice necessitates standardized guidelines, regulatory oversight, and further validation through large-scale prospective studies. As AI technology continues to advance, ongoing investigation into its role in personalized breast cancer screening is essential.