To investigate the current situation of research management in basic hospital,sum up the experience and effects,study the efficient method to improve the level of research management.

Objective Investigation and analysis the innovation ability and its influencing factors about graduates in primary hospitals,discuss corresponding measurements to enhance their innovation capacities.Methods A total number of l17master students and leadership persons at related institutions in primary hospitalsfrom particular district of China were surveyed with self-made questionnaires.Transformational Leadership Questionnaire,Organizational Commitment Questionnaire,and Multi dimensional Innovative Behavior Scale were used to investigate both personal and environmental factors that maybe influential for further discussion of possible improvement strategies.Results Among the 117 master students,having a capacity for independent innovationand getting partial achievements is only 6.84％;that canactively participatingin but temporarily have notborne fruit is 11.96％,24.78％ of which are passively finishingthe task of writing papersunder the request of the hospital,high up to 56.41％ are do not have any achievements in technology innovation yet.In the meanwhile,63.16％ administrators,compared to 36.84％,have negative attitudes to the graduate students.In terms of influence factors,that closely related to creative production,creative execution are identity,virtue and the vision of transformational leadership behavior motivation,charismatic leadership,individualized consideration,and affective commitment,ideal commitment,economic commitment,opportunity commitment of organizational commitment,P＜0.05,the difference has statistically significant;but not correlative with normative commitment,P＞0.05,the difference have not statistically significant.Conclusions The innovation capacityof master students working in primary hospitals is seriously insufficient,and its influence factors are closely related to both personal and environmental factors.Targeted innovation knowledge training and appropriate incentive mechanism are effective measurements to improve their innovation capacity.The necessary condition of facilitiesis thepremise and guarantee for them to carry out the science and technology innovation.

Objective To investigate the identity of the scientific research in different grade hospital medical staff in different levels and analysis of the influence factors and improvement strategy.Methods A total of 453 in different grade hospital medical staff in different levels from some district in China were recruited.Results Hospital of different levels, different titles and different degree and professional medical staff have significant differences to the identity of the scientific research, P＜0.001. Its influence factors including consciousness, ability, interest, atmosphere, time, energy, and so on have significant differences, P＜0.001. Conclusions different grade hospital medical staff in different levels have significant differences to the identity of the scientific research, the higher the level, the higher the identity, but have different influence factors.The level of different grade hospital scientific research should be improved according to different influence factors make corresponding strategies.

Objective Current study was aimed to investigate the barrier of research conduction in primary hospital, andTo take appropriate countermeasures to improve the research ability in primary hospital.Methods Convenience sampling method was adopted, and 302 physicians were selected and interviewed using a designed questionnaire.Results 89.41％ of the participants believed that it is not appropriate to conduct research in primary hospitals because the hospital could not provide appropriate condition for research activity.There were lacks of research consciousness, research atmosphere, and research capacity in primary hospital.Conclusions These medical staff in primary hospital appeared a negative attitude to research, while negative attitude exhibited positive correlation with the level of hospital, academic atmosphere, and research capacity.To improve research capacity in primary hospital, it is important to establish continuing education program to train the physicians for research ability, and to change the research environment in the primary hospitals.In addition, the incentive system may be able to encourage physicians to actively conduct research.

Objective We investigated the correlations between abnormal fetal heart rate (FHR) during the second stage of labor and delivery types and intrapartum maternal complications and fetal outcome Methods The data of 232 nulliparas with single vertex in the second stage of labor (111 cases with normal FHR, 121 cases with abnormal FHR) were analyzed retrospectively Results The incidence of abnormal FHR in the second stage of labor was 52 2%(121/232) The patterns of abnormal FHR included: 81 (66 9%) cases with moderate and/or severe variable deceleration (VD), 27 (22 3%) cases with scattered late deceleration (LD), only one with continuous LD, 4 (3 3%) cases prolonged deceleration (PD), 2 (1 7%) cases with VD and LD, 3 (2 5%) cases with VD and PD, 4 (3 3%) cases with diminished baseline variability There were 13 (11 7%) among the cases with normal FHR and 35 (28 9%) among the cases with abnormal FHR underwent assistant delivery operations (forceps or/and vaccum), respectively ( P

Objective To investigate the influence of transforming growth factor-?2(TGF-?2) on production of tumor necrosis factor -? (TNF-?) and interferon-? (IFN-?) from placenta of patients with intrahepatic cholestasis of pregnancy (ICP). Methods Villous explants from 10 ICP patients(ICP group) and 10 normal gravidae (control group) were cultured in vitro. The concentrations of TNF-? and IFN-? in the culture medium were determined by enzyme linked immunoadsorbent assay ( ELISA) after incubation with different concentrations of TGF-?2 for 1,24 and 48 hours. Results (1) After cultured for 1,24 and 48 hours, TNF-? level in ICP group was (771 ? 187)pg/g, (2 490 ?575)pg/g,and (3339 ? 1106)pg/g, respectively, while IFN-? level was (931 ? 148) pg/g, (1888 ? 545) pg/g, and (3027 ? 667) pg/g, respectively. All were significantly higher than those in the normal group (P

Objective To investigate the effect of T helper cell type-1(TH 1) cytokines [interferon-? (IFN-?), tumor necrosis factor-a (TNF-?)] and T helper cell type-2(TH 2) cytokines [interleukin-4 (IL-4)] on pathogenesis of intrahepatic cholestasis of pregnancy (ICP). Methods The peripheral blood mononuclear cells (PBMC) from 20 cases of ICP patients (study group) and 20 cases of normal pregnant women (control group) were cultured with photohemglutinin stimulation. TNF-?, IFN-? and IL-4 were determined in the supernatant by enzyme- linked-immunoassay. Results (1) In supernatants of cultured PHA induced PBMC, the levels of IFN-? and TNF-? of study group were (639?156) ng/L and (1 021?231) ng/L, which were significantly higher than those of control group, (464?147)ng/L and (728?175) ng/L( P

Objective To investigate the mechanism and the related factors of fetal hypoxia in intrahepatic cholestasis of pregnancy (ICP). Methods Cord blood total bile acids(TBA), hypoxanthine (HX), and endothelin (ET) concentrations were measured in 30 newborns of mothers with ICP and 30 infants of normal pregnancy as control, and the cord nucleated red blood cells (NRBC) were counted as well. Results (1)The mean cord arterious plasma HX concentration in hypoxic fetuses of mothers with ICP was significantly higher than those in fetuses without hypoxia of mothers with ICP and fetuses of normal pregnancy(18.68?15.73)?mol/L, (6.87? 2.82)?mol/L, (6.81?2.83)?mol/L( P 0.05) and the mean cord arterious plasma ET concentration (72.44?12.23) ng/L,(70.16?26.61) ng/L,(67.27?43.56) ng/L, P =0.910) among the three groups. (2) In ICP group, the mean cord serum TBA concentration in hypoxic fetuses was significantly higher than that in fetuses without hypoxia, while the latter was higher than that in control group (23.77?11.82)?mol/L,(14.86?5.46)?mol/L,(9.28?4.39)?mol/L;( P

BACKGROUND: Researches find that grape seed proanthocyanidins (GSP) can eliminate free radicals, protect heart against ischemia-reperfusion injury and enhance learning and memory abilities in experimental animal, but their effects on the cerebral ischemia-reperfusion injury remain unclear.OBJECTIVE: To study the protective effects of proanthocyanidins derived from grape seeds on the cerebral ischemic reperfused brain by measuring the total antioxidative capacity (T-AOC), nitric oxide synthase activities and malondialdehyde (MDA) content in brain tissue of mice.DESIGN: A completely randomized and controlled study.SETTING: Department of Pathophysiology and Functional Central Laboratory, Jinzhou Medical College; Department of Neurology, the First Affiliated Hospital of Jinzhou Medical College.MATERIALS: The experiment was conducted in the Department of Functional Central Laboratory, Jinzhou Medical College from March to August 2004. Forty Kunming mice, provided by the Experimental Animal Center, Jinzhou Medical College, were randomly divided into five groups: sham control group, cerebral ischemia-reperfusion group (IR group) and cerebral ischemia-reperfusion treated with low or high dose of GSP or nimdipine (IR+GSP or IR+Nim) group with eight mice in each group.METHODS: ① Animal model establishment: The animals were anesthetized with ether. Then they were incised through median incision of the neck. The bilateral common carotid arteries were then occluded by microaneurysm clips for 30 minutes. After removing the clips, return of flow was visualized in the arteries. ② Model group and control group:The mice in low or high dose of GSP treated group or nimdipine treated group were injected GSP or nimdipine 10, 40, 2 mg/kg body mass respectively during the common carotid arteries occlusion and again at 24hours after reperfusion, while the mice in sham control group were injected the same volume distilled water with 40 mg/kg body mass. After 72-hour reperfusion, nitric oxide synthase activities, the total antioxidative capacity and MDA content in brain tissue of mice in each group were detected with chemical chromatometry. ③ The results were assessed by t test.MAIN OUTCOME MEASURES: Nitric oxide synthase activities, the total antioxidative capacity and MDA content in brain tissue of mice in each group were detected.RESULTS: Data of forty Kunming mice was entered the results analysis without any loss. ① Total antioxidative capacity: Total antioxidative capacity in cerebral ischemia-reperfusion group was obvious lower than that in the sham control group (t=8.145, P=0.000) while total antioxidative capacity in low or high dose of GSP treated group and nimdipine treated group was obvious higher than that in the cerebral ischemia-reperfusion group (t=6.313, 8.956, 4.14, P ＜ 0.01). ② Nitric oxide synthase activities: Nitric oxide synthase activities in cerebral ischemia-reperfusion group was obvious higherthan that in the sham control group (t=12.541, P ＜ 0.01), while nitric oxide synthase activities in low or high dose of GSP treated group and nimdipine treated group was obvious lower than that in the cerebral ischemia-reperfusion group (t=2.231, 8.956, 7.260, P ＜ 0.05-0.01). ③ MDA content: MDA content in cerebral ischemia-reperfusion group was obvious higher than that in the sham control group (t=7.883, P ＜ 0.01), while high dose of GSP treated group and nimdipine treated group was obvious lower than that in the cerebral ischemia-reperfusion group (t =5.234,4.518, P ＜ 0.01).CONCLUSION: GSP exerted a protective effect on the cerebral ischemic reperfused brain by enhancing total antioxidative capacity and reducing lipid peroxidantion and nitric oxide synthase activities.

Objective To investigate the scientific research ability and training needs of the new posts of medical undergraduates for better training them.Methods A total of 62 new posts of medical undergraduates from a level-two general hospital in China were recruited by questionnaire survey.Resuits the scientific research ability of the new posts of medical undergraduates is poor,so it is very necessary for their in-service training,93.5~ of them have interest in scientific research and hope to get the training,especially want to take part in the practical activity.Conclusions It is not better that the scientific research ability of the new posts of medical undergraduates,so as early as possible to give the scientific research skill training to them.