Objective To explore the effect of multimodal analgesia combined with preemptive analgesia on perioperative pain control and sleep quality in elderly patients with intertrochanteric fracture.Methods A total of 100 elderly patients with femoral intertrochanteric factures were selected as treatment group,and 100 patients were selected as control group.The treatment group was treated with multimodal analgesia and preemptive analgesia,while the control group was treated with the conventional analgesia.The VAS score and the amount of tramadol at preoperative 4 8 h,2 4 h and 2 4 h,3 d,1 week,2 weeks after operation were compared between the two groups.The sleep quality of patients during hospitalization was evaluated by the PSQI score.The length of first time move for exercise and postoperative hospital stay were compared between two groups,and the postoperative Harris hip score at 2 weeks,3 months after treatment and adverse reactions were compared.Results The treatment group had a lower VAS score at preoperative 48 h,24 h and 24 h,3 d,1 week,2 weeks after operation when compared with control group (P ＜ 0.05).Tramadol dose in the control group was significantly higher than the treatment group (P ＜ 0.05),the PSQI score was significantly higher than the treatment group (P ＜ 0.05),the length of postoperative move for exercise was significantly longer than the treatment group (P ＜ 0.05).Harris hip score at 2 weeks after operation in the treatment group was significantly higher than that in control group (P ＜ 0.05),while 3 months after operation,the Harris hip score was similar between the two groups (P ＞ 0.05).The total incidence rate of adverse reactions were similar between the two groups (P ＞ 0.05).Conclusion Application of multimodal analgesia combined with preemptive analgesia is effective and safe in treatment of elderly patients with femoral intertrochanteric fracture,it can improve the sleep quality,promote the hip joint function recovery of patients in early stage.

Objective To explore the effect of sufentanil on preventing early pain afteRanesthesia surgery.Methods A total of 295 patients with colon canceRsurgery were randomly divided into sufentanil group and control group.The MAP,HR,SPO2 and restless score at different time points were compared between two groups.The pain score,sedation score and VAS score were compared between the two groups.The complications were compared.Results The MAP and HRat T1 in the sufentanil group were significantly higheRthan those in the control group (P<0.05).The first time pain score in the sufentanil group was significantly loweRthan the control group (P<0.05).The VAS scores of sufentanil group at T1,T2,T3 were significantly loweRthan the control group (P<0.05).The incidence rate of postoperative complications in sufentanil group was significantly loweRthan the control group (P<0.05).Conclusion Sufentanil is effective in preventing early pain afteRsurgery.

Objective To explore the effect of multimodal analgesia combined with preemptive analgesia on perioperative pain control and sleep quality in elderly patients with intertrochanteric fracture.Methods A total of 100 elderly patients with femoral intertrochanteric factures were selected as treatment group,and 100 patients were selected as control group.The treatment group was treated with multimodal analgesia and preemptive analgesia,while the control group was treated with the conventional analgesia.The VAS score and the amount of tramadol at preoperative 4 8 h,2 4 h and 2 4 h,3 d,1 week,2 weeks after operation were compared between the two groups.The sleep quality of patients during hospitalization was evaluated by the PSQI score.The length of first time move for exercise and postoperative hospital stay were compared between two groups,and the postoperative Harris hip score at 2 weeks,3 months after treatment and adverse reactions were compared.Results The treatment group had a lower VAS score at preoperative 48 h,24 h and 24 h,3 d,1 week,2 weeks after operation when compared with control group (P ＜ 0.05).Tramadol dose in the control group was significantly higher than the treatment group (P ＜ 0.05),the PSQI score was significantly higher than the treatment group (P ＜ 0.05),the length of postoperative move for exercise was significantly longer than the treatment group (P ＜ 0.05).Harris hip score at 2 weeks after operation in the treatment group was significantly higher than that in control group (P ＜ 0.05),while 3 months after operation,the Harris hip score was similar between the two groups (P ＞ 0.05).The total incidence rate of adverse reactions were similar between the two groups (P ＞ 0.05).Conclusion Application of multimodal analgesia combined with preemptive analgesia is effective and safe in treatment of elderly patients with femoral intertrochanteric fracture,it can improve the sleep quality,promote the hip joint function recovery of patients in early stage.

Objective To explore the effect of sufentanil on preventing early pain afteRanesthesia surgery.Methods A total of 295 patients with colon canceRsurgery were randomly divided into sufentanil group and control group.The MAP,HR,SPO2 and restless score at different time points were compared between two groups.The pain score,sedation score and VAS score were compared between the two groups.The complications were compared.Results The MAP and HRat T1 in the sufentanil group were significantly higheRthan those in the control group (P<0.05).The first time pain score in the sufentanil group was significantly loweRthan the control group (P<0.05).The VAS scores of sufentanil group at T1,T2,T3 were significantly loweRthan the control group (P<0.05).The incidence rate of postoperative complications in sufentanil group was significantly loweRthan the control group (P<0.05).Conclusion Sufentanil is effective in preventing early pain afteRsurgery.

Objective:To describe the prevalence of food allergy among children aged 0-5 years in China and to explore related influencing factors.Methods:Multistage stratified random sampling method was used to collect data from 275 surveillance sites of the China National Nutrition and Health Survey of Chinese children and lactating mothers programs in 31 provinces (autonomous regions and municipalities) of China in 2016-2017. A total of 70 107 participants aged 0-5 years were included in this study. The study collected information of participants' demographic characteristics and food allergies by face-to-face questionnaire. The prevalence of food allergy was analyzed, using the complex data weighting method. The logistic regression models were used to analyze the influencing factors related to food allergy.Results:The overall prevalence of self-reported food allergy among children aged 0-5 years was 4.81%. Prevalence rates in infants aged 0-5 months, and 6-23 months and preschool children aged 2-5 years were 0.81%, 4.68% and 5.26%, respectively. The results of logistic analysis showed that there was a significantly positive correlation between factors including children from 6 months to 5 years old, urban area, southwest area, first-born, mothers with college education or above, and the prevalence of food allergy in children. Shrimp, poultry eggs, crab shellfish, fruit, milk and fish appeared the common allergic foods in children aged 0-5 years, with prevalence rates of self-reported food allergy as 1.55%, 1.25%, 0.99%, 0.97%, 0.87% and 0.86%, respectively. The proportion of single food allergy in children with allergies was 69.85%.Conclusions:Among children aged 0-5 years, the prevalence of self-reported food allergy increases with age, in China. Foods that is prone to allergies include fish, shrimp, crab, shellfish, poultry eggs, milk and fruits, etc. Most allergies were only caused by single food in children, under observation.

Objective:To investigate the effect of MCC950 (a NLRP3 inflammasome inhibitor) on cognitive impairment in mice with radiation-induced inflammatory brain injury.Methods:Mice were divided into normal (NS) group, whole body irradiation (IR) group and MCC950 intervention post irradiation (IR+ MCC950) group according to the random number table method, with 15 mice in each group. The mice in IR group and IR+ MCC950 group were irradiated with a single dose of 4.0 Gy. The radiation source was 137Cs and the dose rate was 1.118 Gy/min. The mice in NS group were not irradiated. Mice in IR+ MCC950 group were injected intraperitoneally with MCC950 once a day (10 mg/kg each time) from 3 weeks after irradiation. Behavioral tests such as new and old things recognition experiment and social cognition experiment were used to detect the cognitive function of mice. Immunohistochemistry was used to detect the expression of NeuN protein in CA3 area of mouse hippocampus. PCR and Western blot were used to detect the expression of NLRP3 inflammatory body related protein. Results:Compared with NS group, the short-term and long-term recognition index of new and old things in the IR group decreased significantly ( t=4.321, 5.473, P<0.01), and the social cognitive recognition index of the IR group also decreased significantly ( t=2.097, P<0.05). MCC950 treatment reversed the above changes (short-term and long-term new and old thing recognition test: t=5.860, 4.598, P<0.05; new and old position recognition test: t=3.040, P<0.05; social cognition test: t=4.021, P<0.01). The expression of NLRP3, Caspase-1, IL-1 β and IL-18 in mice hippocampus of the IR group was significantly higher than that of the control group ( t=2.699, 8.515, 3.340, 3.950, P<0.05). Compared with NS mice, radiation significantly increased the expressions of Bax, Caspase-3 and PARP1 in hippocampus ( t=3.887, 2.742, 3.287, P<0.05), while MCC950 significantly decreased the expressions of Bax, Caspase-3 and PARP1( t=2.852, 4.090, 9.614, P<0.05). Conclusions:NLRP3 inflammasome inhibitor MCC950 could alleviate radiation-induced cognitive impairment, which may be due to the inhibition of hippocampal inflammatory and neuronal death.

Objective:To investigate sleep quality in pregnant women during their first and second trimester and to identify risk factors.Methods:Data was from the Chinese Pregnant Women Cohort Study. A total of 3 618 pregnant women were included, with the exclusion 346 women who had missing information. Sociodemographic, health-related behavior, depression and sleep quality information were collected and analyzed. Logistic regression analysis were used to explore the influencing factors of sleep quality in pregnant women.Results:Among the 3 618 pregnant woman 28.2% had poor sleep quality in their first trimester and 28.7% in the second trimester. 15.2% pregnant women had progressively worse sleep and 13.0% had persistently poor sleep had pregnant women were generally suffered from poor sleep quality, difficulty falling asleep, sleep disorders and daily fatigue. Regular diet ( OR=0.75, 95% CI: 0.62-0.92) and work ( OR=0.84,95% CI: 0.71-0.99) in the first trimester were protective factors of sleep quality in pregnant women. Age ≥30 year old ( OR=1.19, 95% CI: 1.03-1.37), passive smoking ( OR=1.18, 95% CI: 1.02-1.36) and depression ( OR=2.25, 95% CI: 1.95-2.61) in the first trimester were risk factors. Conclusions:The rate of poor sleep quality are high among Chinese pregnant woman during their first and second trimester. The risk factors of sleep quality are multiple. Regular diet and work, reduction of tobacco exposure, alleviation of depression symptom may help improve sleep quality among pregnant women.

Objective:To investigate the effect of changes in physical activities on depressive symptoms in the second trimester of pregnancy.Methods:Data from the Chinese Pregnant Women Cohort Study, from July 25, 2017 to November 26, 2018, were used. Women who had effectively completed the survey of physical activity and depressive symptoms in the first and second trimesters of pregnancy, were recruited. Both International Physical Activity Questionnaire-short and Edinburgh Postnatal Depression Scale were used, respectively. Pregnant women who had completed two surveys were included in our study and were divided into two groups according to the depressive symptoms, measured at the baseline. Among the pregnant women without depressive symptoms at the baseline, logistic regression was used to analyze the effects of changes in physical activity on the prevention of depressive symptoms. Effect on the reduction of depressive symptoms was analyzed, using the same method.Results:The prevalence rates of depressive symptoms were 23.83 % and 20.57 % in the baseline and second trimester, respectively. After adjusting for age, education level, occupation, family annual income and pre-pregnancy BMI, data from the logistic regression showed that women without depressive symptoms and with increased and adequate physical activities in the baseline, were with lower risks to develop depressive symptoms in the second trimester ( OR=0.479, 95 %CI: 0.335-0.684; OR=0.566, 95 %CI: 0.394-0.815). Among women with depressive symptoms in the baseline survey, association between physical activity and depressive symptoms was not statistically significant ( P>0.05). Conclusions:Increased and adequate physical activities showed preventive effects on depressive symptoms during pregnancy, but the remission effect was not obvious in women with depressive symptoms. Pregnant women should be encouraged to increase their physical activities while screening programs should also be carried out to reduce the depressive symptoms during pregnancy.

Objective:To prospectively explore the associations between total and different types of physical activities and gestational diabetes mellitus (GDM) in the first trimester of pregnant women, in Beijing.Methods:Data of 909 participants from the Chinese Pregnant Women Cohort study were extracted and studied. Four types of physical activities, including household/care-giving, occupational, sports/exercise and outdoor ways of transportation (walking/cycling/E-biking) in early pregnancy were studied by using the pregnancy physical activity questionnaire (PPAQ). All the participants were followed up and related data on GDM collected. Logistic regressions were conducted for data analysis on the associations of interests.Results:A total of 206 pregnant women (22.7 %) were diagnosed with GDM. After adjusting for age, pre-pregnancy BMI, family history of diabetes and other types of physical activities, results from the logistic regression showed that women with moderate level of household/care-giving activities were with the lower odds on GDM ( OR=0.654, 95 %CI: 0.436-0.980). Women who had met the guideline of exercise were less likely to have GDM ( OR=0.518, 95 %CI: 0.287-0.934). There was no significant association appeared between total physical, occupational and outdoor ways of transportation (walking/cycling/E-biking) activities with GDM. Conclusions:Sports/exercise and household/care-giving activities in early pregnancy appeared important on GDM prevention. Pregnant women are encouraged to wisely arranging their sports/exercise activities and engaging in moderate household/care-giving activities in the first trimester of pregnancy, to prevent GDM.

Objective:To explore the association between parental socioeconomic status (SES) and preschoolers’ consumption of sugar-sweetened beverages (SSB).Methods:In June 2018, all preschoolers from 15 kindergartens were selected from the jurisdiction of Education Commission in Dongcheng District of Beijing by using an equal-proportion stratified cluster sampling method in the study. A self-designed questionnaire was used to investigate the parents of preschoolers to obtain the basic information of preschoolers and parents, the consumption situation of preschoolers’ sugar-sweetened beverages and the perception of parents to SSB. A tatol of 3 217 preschoolers were finally included in the analysis. A generalized structural equation model was used to analyze the relationship between preschoolers' consumption of sugar-sweetened beverages and their parents' socioeconomic status and the mediating effect of their cognition of sugar-sweetened beverages. The size of mediating effect was estimated by using deviation correction non-parameter percentile Bootstrap method.Results:The age of 3 217 preschoolers was (4.23±0.67) years, of which 52.6% ( n=1 692) were boys, and 77.62% ( n=2 497) were SSB consumers. Among the parents of 3 217 preschoolers, fathers and mothers accounted for 24.90% ( n=801) and 75.10% ( n=2 416), and the M ( P25, P75) scores of SES were 66.7 (62.5, 69.5) and 69.5 (64.6, 71.4), respectively. The proportion of parents who took the initiative to learn about their children's consumption of SSB, lacked confidence in restricting preschooler's consumption of SSB and read nutrition labels before purchasing food was 74.08% ( n=2 383), 82.90% ( n=2 667) and 36.24% ( n=1 166), respectively. The generalized structural equation model showed that after adjusting for preschoolers’ gender, age, body mass index (BMI) of preschoolers and their parents, preschoolers’ consumption of SSB was negatively associated with their parents’ SES score [path coefficient (95% CI):-4.69×10 -2 (-6.56×10 -2,-2.69×10 -2) ]. The mediating effect of parents’ perception of SSB consumption could explain 48.71% of the total effect [path coefficient (95% CI):-2.28×10 -2 (-3.54×10 -2, -1.10×10 -2)]. Conclusion:The consumption of SSB in preschoolers is negatively associated with their parent’s SES, and this relationship is partially mediated by parent’s perception of SSB consumption.