Objective To investigate the effect of Bushen Digui Decoction in treatment of chronic nephritis proteinuria of spleen kidney qi deficiency.Methods 100 patients with chronic nephritis of spleen kidney qi deficiency were randomly divided into two groups,and each group had 50 cases.The control group was given lotensin,while the study group was given Bushen Digui Decoction.The relationship between proteinuria,kidney function improving and TCM clinical signs in the two groups were observed.Results The effective rate of study group was 76.0％,which was significantly higher than that of the control group 62.0％ (P ＜ 0.05).The effective rate of the study group according to the TCM criteria was 82.0％,which was significantly higher than that of the control group 52.0％ (P ＜0.01).24h urinary protein in the control group before treatment was (1.89 ±0.87) g,after treatment for six months was (1.45 ±0.63)g,those of the study group was (1.90 ±0.86)g,(1.01 ±0.58)g.24h urine protein in beth two groups after treatment was decreased,and the difference was statistically significant (P ＜ 0.05).After treatment,the low back pain,shortness of breath,fatigue,edema,loose stools diarrhea,frequent urination,or nocturia range of TCM symptom score improvement of the study group were significantly better than control group (P ＜ 0.05),while TCM main symptoms before and after treatment showed no improvement in the control group.Before and after the treatment,the study group and the control group in the total protein content,kidney function markers (SCr,BUN,Alb and CCr content) had no significant differences (P ＞ 0.05).Conclusion Bushen Digui Decoction can significantly improve patients' kidney function and reduce proteinuria remission in patients with low back pain,shortness of breath,fatigue,swelling,loose stools diarrhea,frequent urination,or nocturia many other symptoms.