During 1920-30s,under the push of Kuomintang,Communist Party and social personage,the Chinese village launched a cooperation movement. Although they failed to renew rural areas in China,the farmer autonomy spirit, policy practicality,the educational principles,and the spirit of evidence-based demonstration research embodied in the movement still have an enlightening significance to the construction of the new rural cooperative healthcare system and construction of new-type villages.

Objective To evaluate the academic level and the popularity of Chinese Journal of Radiation Oncology Methods According to the information of Chinese Medical Citation Index(CMCI),statistically analyzed the amount and distribution of the originals in Chinese Journal of Radiation Oncology cited by the journal included by CMCI.Results The proportion of cited articles for original articles,short report and review were(73.8%),58.1% and 60.7% respectively,and average cited numbers for them were 7.2,3.0 and 3.4.The average of original articles cited by other researchers is 3.9,and there are more articles cited than other journal.The authors of these articles are from the 27 province/or municipalities,Beijing and Shanghai municipalities are in the front of Radiation Oncology research.There are 320 citing journals,and self-citing rate is 9.4%.Conclusions The Chinese Journal of Radiation Oncology has published high quality articles,and has its own edition characteristics to keep its steady level of research.It is the one of the most important information resource for the radiation oncology researchers and the most important medical journal.

Based on previous research on the knowledge network,the paper summarizes the relevant research on the concept evolution,structure,model,evaluation index and practical application of the knowledge network based on the literature carrier,and provides reference for knowledge management and scientific innovation management.

Objective To analyze the epidemiological characteristics and trend of human brucellosis in Zibo.Methods The data of brucellosis was derived from China information system for diseases control and prevention, from the epidemiology case study and outbreak event of brucellosis.Descriptive statistical analysis was used to analyze the incidence, the distribution of time, region and population, the transmission, seropositive rate of vulnerable groups, and the epidemiological characteristics of the cases from 2006 to 2014.Results A total of 541 brucellosis cases were reported between 2006 and 2014, the incidence rates increased from 0.16 per 100 000 to 4.94 per 100 000, and cases were found in about 65％ (62/95) of the towns.The disease showed a seasonal cycle with peak period between March and August annually, accounting for 70.61％ (382/541) of the total cases.Vocational high risk population were animal keepers, butchers, sellers and producers, accounting for 73.20％ (396/541), and foodbome infection accounted for 9.61％ (52/541).A total of 8 outbreak events were reported from 2006 to 2014.Conclusions The incidence of brucellosis has increased and the epidemic areas have expanded year by year.Spring and summer are the peak seasons of the disease.Foodborne infection is increasing.

Objective To explore the effect of team-based tutorial system to nursing student in the order cultivation Pattern.Methods This study used the convenience sampling method.109 students were choosed from orientation training classes that 2012 and 2013 grade as the research subjects.The 59 students from 2013 grade as the test group,implement team-based tutorial system to them in the fourth semester.The 50 students from 2012 grade that had been implemented general management as the control group,then compare the fourth semester final grade,classes atmosphere,the evaluation of patients and clinical teachers over the same period.Results The test group and control group students' scores of their fourth semester final grade,classes atmosphere,the evaluation of clinical teachers and patients were (92.39±2.39),(3.45±0.64),(95.33±2.01),(94.75±2.38) points and (90.91±2.62),(3.14±0.63),(91.00±1.82),(90.63±2.34) points.There was difference between them,and the difference was statistically significant (t=-7.82 ～ 3.06,P ＜ 0.05).Conclusions The implementation of team-based tutorial system to nursing student in the order cultivation pattern can improve students' academic performance,improve their class atmosphere and their communication skills so that patients get good evaluation of patients and clinical teachers.

Background and purpose:Lung cancer is the one with the highest incidence tumors, is mainly appeared to be non-small cell lung cancer(NSCLC). The main treatment method is chemotherapy. However, it is controversial whether using chemotherapy in the patients of advanced NSCLC. The present study aimed to observe the efifcacy and toxicity of pemetrexed contrast to the best supportive care in the NSCLC patients of ECOG=2 and older than 70.Methods:A total number of 84 patients of ECOG=2 and older than 70 with advanced NSCLC were randomly assigned into two groups. The study group accepted pemetrexed, 500 mg/m2,every 3 weeks as a cycle, and the control group was given 200 g glucose supply and protein according to patients’ weight every day. Evaluation of the study group was performed at end of 2 cycles and the control group was evaluated after 2 months.Results:There was no CR patient in 2 groups. In the study group there were 6 patients of PR (14.3%), 21 patients of SD (50%) and 13 patients of PD (30.9%), the effective rate was 14.3%, and the disease control rate was 64.3%. There were 1 patient of PR (2.4%), 15 patients of SD (35.7%), 25 patients of PD (60.9%), 1 patient of death, the effective rate was 2.4% and the disease control rate was 39.0% in the control group (P<0.05).Conclusion:The study group has better treatment effect and adverse reaction in patients of ECOG=2 and older than 70 with advanced non-small-cell lung cancer and the toxicity could be tolerated.

Objective: To study 63 cases of nasal tumors treated by dermatologic surgery, and analyze their generality and characters. Methods: The cases were analyzed with SPSS 10.0 and SAS6.12. Results: The average age of the patients was 46.92?18.63.The number of man was about equal to that of women. Most cases were basal cell carcinoma (42.9%). Nevus came second (38.1%). The other cases were benign tumors. The distribution of operational locations showed the character of nasal surgery. Operations of Alar occupied 52.4%,22.2% were on the dorsal and 15.9% on the tip. Other locations occupied 9.5%. Cases of primary close occupied 69.8%. Cases applying complex close were 30.2%. Statistic analysis illustrated that primary close was different from complex close with distribution of operational locations. The area of defects between primary close and complex close was also different. At the same time, the differentiation of applying complex close was obvious between malignant tumors and benign tumors. Conclusion: Skin cancers and benign tumors usually occur on the nose, so it is very important to master the techniques of plastic surgery to repair the defects of nose, besides removing tumors perfectly by the classical way of dermatologic surgery, Mohs Micrographic Surgery.

OBJECTIVE:To study the centralized dispensing mode in outpatient pharmacy of large hospital METHODS:To establish the label dispensing system and management strategy RESULTS & CONCLUSION:Dispensing is the heart of a pharmacy Good networking system with efficient workflow and rational use of manpower could determine the success in a pharmacy,such as no dispensing error,no illegible handwriting,short wait-time automation of management of drug information and statistics of pharmacist's work load and rise of dispensing efficiency and quality of service

Objective To investigate the clinicopathological relation between the TNF-? and IgA nephropathy. Methods TNF-? levels in serum, urine and renal tissues of 50 patients with IgA nephropathy were measured, and 10 patients with minimal change nephrotic syndrome(MCNS) and 10 healthy subjects served as negative control group. Results The serum and urine levels of TNF-? in the patients with IgA nephropathy were significantly higher than those in the patients with MCNS and healthy subjects, and had a significant positive correlation with the degree of proteinuria and renal demage. TNF-? expression was mainly localized in the cytoplasm of the proximal renal tubular epithelial cells, and the interstitium with more monocyte-macrophages infiltration. Conclusion TNF-? took part in the onset of hematuria and proteinuria, was correlated with the degree of renal damage, and played an important role in the aggravation of IgA nephropathy.

Objective To estimate the application value of dermoscopy in the differential diagnosis of basal cell carcinoma (BCC).Methods Patients who underwent dermoscopic examination and had been definitely diagnosed by pathological examination in the Peking University First Hospital were enrolled in this study.In a blind study,dermoscopic images of 86 BCC lesions from 81 patients (case group) and 68 non-BCC hyperpigmented lesions with similar degree of hyperpigmentation and location from 61 patients (control group) were evaluated for features suggestive of BCC and melanocytic lesions.The diagnostic capability of dermoscopy in patients with BCC was evaluated by diagnostic test.Pathology served as the gold standard method for diagnosis.The frequency of features suggestive of melanocytic lesions was calculated in BCC lesions,and dermatoscopic findings were compared between heavily and lightly pigmented BCC lesions.Results The sensitivity,specificity,positive predictive value,negative predictive value of the classic dermoscopic pattern for the diagnosis of BCC were 98.84％,89.71％,92.39％,98.39％ respectively,with a Youden index of 0.88.The coincidence rate was 94.81％ between pathologic and microscopic diagnosis.Pigment network,multiple brown to black globules/dots,pigmentation around hair follicle openings were observed more frequently in melanocytic lesions compared with BCC lesions (all P ＜0.05).Blue-whitish veil-like structures were observed in 61.63％ of the BCC lesions.The presence of blue-black blotch and blue-whitish veil-like structures was significantly more frequent in heavily pigmented BCC lesions than in lightly pigmented BCC lesions (both P ＜0.01).Conclusions The classic dermoscopic pattern of BCC shows a favorable diagnostic capacity in Chinese population.Large-scale studies are needed to estimate the value of some features proposed in this study,such as peripheral pigment in palisade arrangement,peripheral hyperpigmentation and hypo-or hyperpigrnentation around hair follicle openings,in the differential diagnosis of pigmented diseases.