ObjectiveTo analyze the correlation between serum 25-hydroxyvitamin D level and nonalcoholic fatty liver disease (NAFLD), and to provide a clinical basis for the prevention and treatment of NAFLD. MethodsFrom March to October, 2014, 200 Uyghur patients and 200 Han patients with NAFLD in our hospital were enrolled into NAFLD group, while an equal number of healthy Uyghurs and Hans were used as controls. For all subjects, questionnaire survey, physical examination, abdominal ultrasound examination, and blood biochemical examination were performed, and serum 25-hydroxyvitamin D level was determined using enzyme-linked immunosorbent assay. The relationship between 25-hydroxyvitamin D and NAFLD was analyzed by Spearman correlation analysis and multivariate logistic regression analysis. ResultsSerum 25-hydroxyvitamin D levels in the NAFLD group were significantly lower than those in the control group for both Uyghurs and Hans (P＜0.05), and serum 25-hydroxyvitamin D level was negatively correlated with NAFLD (rHan=-0.212, rUyghur=-0.220, P＜0.01). The results of multivariate logistic regression analysis showed that the rising serum 25-hydroxyvitamin D level was a protective factor for NAFLD (ORHan=0.894, PHan=0.015; ORUyghur=0.897, PUyghur=0.025). ConclusionSerum 25-hydroxyvitamin D level is closely associated with NAFLD in Uyghurs and Hans.

BACKGROUND:There have been many studies on adjacent vertebral fractures in elderly female patients with osteoporotic vertebral compression fractures,but their related risk factors are still in debate.There are also few studies on how to intuitively present their risks for clinical application. OBJECTIVE:To analyze the risk factors of adjacent vertebral refracture in senile women with osteoporotic vertebral compression fracture and construct a Nomogram prediction model. METHODS:A total of 268 elderly female patients with osteoporotic vertebral compression fracture who came to Ganzhou People's Hospital for treatment from January 2018 to November 2022 were selected and divided into study group(adjacent vertebral refracture,n=31)and control group(no adjacent vertebral refracture,n=237)according to whether adjacent vertebral refracture occurred 3 months after percutaneous vertebroplasty.General clinical data were compared between the two groups.Multivariate Logistic regression analysis was conducted to analyze the independent risk factors of adjacent vertebral refracture in elderly women with osteoporotic vertebral compression fracture.A Nomogram prediction model was constructed by R software"rms"package. RESULTS AND CONCLUSION:(1)There were statistically significant differences in age,menopause age,body mass index,fracture history,number of fractured vertebra before surgery,bone cement leakage,bone density,postoperative kyphotic deformity angle,and preoperative Oswestry disability index between the two groups(P<0.05).(2)Multivariate logistic regression analysis results showed that age(>69 years old),menopause age(≤51 years old),body mass index(>24.7 kg/m2),fracture history(presence),number of fractured vertebra before surgery(≥2),and postoperative kyphotic deformity angle(>13°)were independent risk factors for adjacent vertebral refracture in elderly female osteoporotic vertebral compression fracture patients(P<0.05).(3)Nomogram prediction model decision curve results displayed that when the risk threshold was>0.09,this prediction model provided significant additional clinical net benefit.(4)These findings indicate that older age,lower menopause age,higher body mass index,history of fracture,more vertebra fractures before surgery,and larger kyphosis angle after surgery are independent factors for adjacent vertebral refracture in elderly women with osteoporotic vertebral compression fracture.This Nomogram prediction model will provide important strategic guidance for the prevention and treatment of adjacent vertebral refracture in elderly women with osteoporotic vertebral compression fracture.