Objective To evaluate the effect of a new adjuvant preoperative and postoperative chemotherapy on patients with rectal cancer.Methods 113 patients with rectal cancer consisted of two groups: T group (n=55), 5 Fu (5 fluorouracil)10 20 ml,keep down clysis qn,for ten times before opretion.5 Fu 500 mg/ m 2 ,CF(Leucovorin) 30mg/m 2 or 300 mg/m 2,iv qd for five times one week after operation;C group(n=58), 5 Fu 500 mg/m 2,iv.for five times befor surgery.5 Fu 500 mg/m 2 iv qd for five times one week after surgery.Results 3 years surivival rates,the counts of WBC. 16pc.were not statistically different between two groups.But 5 years surivival rates,the recurrence rates and infection rates postopretion of patients were statistical different. Conclusion 5 Fu keep down clysis pre opretion and 5 Fu/CF iv. postopretion can increase 5 years surivival rates and decrease recurrence rates of patients were with rectal cancer.

Objective To study the relationship between the MRI features of acute cerebral infarction (ACI) and developing vascular dementia (VD). Methods The patients who had ACI history more than 6 months were divided into vascular dementia group and no vascular dementia group by MMSE and CDR evaluations. The MRI data of acute stoke of the two groups were reviewed and analyzed retrospectively. Results In VD group the happenings of infarction at subcortex of lobus frontalis, subcortex of lobus temporalis, anterior capsula interna, knee of capsula interna, nucleus caudatus and thalamus were more than those in no vascular dementia group (P

Objective To give a dose reference to the researcher who study prevention of restenosis using endovascular brachytherapy Methods The dose distributions around a 3 mm diam by 20 mm long balloon filled with 90 Y , 32 P and 186 Re separately have been calculated by a computer program based on a dose point kernel Results The peak value of the absorbed dose is found inside the balloon, the inflexion of the dose curve at the endothelial surface of the vessel In the vessel tissue the dose decreases with distance in an approximately exponential manner The lower the nuclide energy is, the faster the dose falls with distance, and the longer the region of uniform dose distribution along vessel wall is The dose rate at the surface of the vessel wall is approximately 74, 71, and 45 mGy/min per mCi/ml, with the dose rate decreasing to 53%, 48% and 28% at 0 5 mm for 90 Y , 32 P and 186 Re separately Conclusion The fast falling of the dose in an approximately exponential manner in the vessel tissue makes for focusing ? radionuclide energy to the vessel wall target and reducing the injury of the normal tissue around the vessel, and especially 186 Re with lower energy has a more obvious advantage in this aspect

Objective To evaluate CT diagnostic value in the facet syndrome of lumbar spine.Methods CT fingings in 64 cases with facet syndrom were retrospectively analysed,53 males and 11 females,aged 39～70 years with a mean of 54.5.Results The main abnormalties demonstrated by CT included:(1)Hypertrophy of articular process,osteophyte formation,leading to stenosis in joint,lateral recess,lumbar intervertebral foramen and lumbar spinal canal.(2)Sclerosis of articular aspect,cystic region and defect on boder of the articular aspect.(3)Vacuum phennomenon,asymmetry of the joint and subluxations.Conclusion CT can demonstrate anatomic structure and pathologic change of the articular joints clearly,and provide reliable images for diagnosis of facet sydrome.

Objective To explore the relationship between human papilloma virus(HPV)andUreaplasma urealyticum (UU)in-fection in women.Methods A total of 412 outpatient women were checked for 23 HPV DNA types by PCR-RDB.The patients were divided into observation group with HPV infection and control group(random selection 50 cases without HPV infection).UU was detected by real-time quantitative PCR in two groups.Results The HPV positive rate was 12.86%(53/412).16 of 23 HPV types were detected.HPV52 was the most common type.The positive rates of UU for observation group(60.38%,32/53)was sig-nificantly higher than control group(30.00%,15/50),P <0.05.Conclusion The reproductive tract HPV infection in women is re-lated to UU infection.It should be paid attention to in the clinical treatment.

Objective To investigate the mechanism that cause allelic dropout of amelogenin gene on X chromosome(Amel-X)when using routine Sullivan106/112 bp primer set in sex identification and discuss its influence on the forensic sex identification and the clinical diagnosis.Methods Amel-X dropout was validated with Sullivan212/218 bp and Haas-Rochholz80/83 bp primer sets.Amplification of amelogenin gene was used to analyze dropout of the Amex-X followed by sequencin.Results Sullivan212/218 bp and Hgas-Rochholz80/83 bp primer sets could be used to identify gender correctly.Three types of point mntation were observed in the forward primer binding region of the Sullivan106/112 bp primer set by sequencing in the lost Amel-X,including single point mutation at 2nd and 13th sites,respectively,and heterozygous multiple point mutations at 2nd and 13th sites.Conclusions Point mutation in the primer binding region may result in a failure to amplify amelogenin allele and thus lead to a null allele.This finding should be mid attention to because it may interfere with the sex identification.

Objective:To observe the clinical curative effect of integrated traditional Chinese and western medicine in the treat-ment of patients with ocular herpes zoster. Methods:Seventy patients with ocular herpes zoster in our hospital were selected during De-cember 2011 to December 2013. According to random number table,the patients were divided into two groups. The patients in the con-trol group were treated with ganciclovir 5. 0 mg·kg-1 ·h-1 , ivd, qd and ganciclovir ophthalmic gel, qid. The patients in the observa-tion group were treated with Banlangen granules and acupuncture additionally. The clinical efficacy, the time of blistering, pain and crusting and adverse reactions in the two groups were observed and compared. Results:After the treatment, the effective rate of the ob-servation group was 94. 29% , while that of the control group was 77. 14% (P<0. 05). The time of blistering, pain and crusting in the observation group was significantly shorter than that in the control group (P<0. 05). The incidence of adverse reactions of the ob-servation group was 2. 86%, while that of the control group was 11. 43%(P>0. 05). Conclusion:The clinical efficacy of integrated traditional Chinese and western medicine in the treatment of ocular herpes zoster is obviously better than that of western medicine treat-ment alone with fewer adverse reactions and shorter time of blistering, pain and crusting.

Objective To summarize the experience of peri-operative emotion management of male patients with breast cancer. Methods The clinical data of 11 male patients with breast cancer were analyzed to summarize methods for the emotion management before, during and after chemo-radiotherapy. Result All the patients took a good attitude and complete the therapy after implementation of emotion management. Conclusion Peri-operative psychological management is of help for their alleviating the negative moods of helplessness, strengthening their confidence, stabilizing and improving the emotions, and finally making them cooperative in the treatment and nursing.

Objective To evaluate serum eystatin C as a marker of glomerular filtration rate(GFR)in kidney diseases and as screening test to detect reducing of GFR.Methods Serum cystatin C,serum creatinine and urine creatinine were measure in 81 patients with various nephropathies in our hospital.Additionally,serum eystatin C of 100 blood do- nors were measured as normol controls.Results The relationship rate between cystatin C and 24 hours creatinine clean- rance(R=-0.657)is better than between serum creatinine and 24 hours creatinine(R=-0.573).To creatinine cleanrance estimated by Cockcroft-Gault formular(Cockcroft),we also obtain the same results(r=-0.674 vs r=- 0.596).Cystatin C showed a high sensitivity and negative predictive value for detecting impaired glomerular function in patients,but the specificity and positive predictive valuewas slight low.There were no significantly differ between cysta- tin C and creatinine in receive-operating characteristic plot(ROC).Conclusion Cystatin C is a better marker than creatinine to detect reduced GFR as measured by 24 hours creatinine eleanrance and Cockcroft-Gault formular.The ef- ficacy of Cystatin C as a screening test need more confidents.

Objective To observe the changes of the quality of life in type 2 diabetes accompanying subclinical atherosclerosis and explore the effect of diabetic macrovascular complications in the quality of life.Methods One hundred and thiry-six type 2 diabetes were measured carotid intima media thickness (IMT) and then divided into AS group(n =51) and CON group(n =85).Two groups were examined with Special of Quality of Life for Diabetes Mellitus (DSQL).Plasma glucose,plasma insulin,glycosylated hemoglobin(HbA1c),high sensitivity C-Reactive Protein (hs-CRP) as well as insulin resistance index (HOMA-IR) and body mass index (BMI) were observed.Results The scores of DSQL and all domains had obvious difference between AS group and control group(P ＜0.05 orP ＜0.01) ;Relative to the control group the AS group was significantly increased BMI,HbA1c levels,hsCRP levels.The DSQL was associated with IMT,BMI,HbA1c,hsCRP,HOMA-IR.Conclusion The diabetic macrovascular compliations might result in impaired quality of life,which is associated with hyperglycemia,insulin resistance,inflammation,and central obesity.Psychotherapy and health education are very important for the improvement the DSQL in type 2 diabetic accompanying subclinical atherosclerosis.